Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome
Neurobiol Dis. 2024 Feb 16:106440. doi: 10.1016/j.nbd.2024.106440. Online ahead of print.ABSTRACTLimited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model of IBS-C. In the current study, C57BL/6 mice were randomly divided into normal control, IBS-C model control, sham-electrostimulation (sham-ES), taVNS, and drug treatment groups. The effects of taVNS on fecal pellet number, fecal...
Source: Neurobiology of Disease - February 18, 2024 Category: Neurology Authors: Jie Liu Qian Dai Tong Qu Jun Ma Chaolan Lv Haitao Wang Yue Yu Source Type: research
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
In conclusion, we find that Tardbp M323K homozygous mutant mice model many aspects of human TDP-43 proteinopathies, evidencing a dual role for TDP-43 in brain morphogenesis as well as in the maintenance of the motor system, making them an ideal in vivo model system to study the complex biology of TDP-43.PMID:38367882 | DOI:10.1016/j.nbd.2024.106437 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 17, 2024 Category: Neurology Authors: Juan M Godoy-Corchuelo Zeinab Ali Jose M Brito Armas Aurea B Martins-Bach Irene Garc ía-Toledo Luis C Fern ández-Beltrán Juan I L ópez-Carbonero Pablo Bascu ñana Shoshana Spring Irene Jimenez-Coca Ram ón A Muñoz de Bustillo Alfaro Maria J S ánchez Source Type: research
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
In conclusion, we find that Tardbp M323K homozygous mutant mice model many aspects of human TDP-43 proteinopathies, evidencing a dual role for TDP-43 in brain morphogenesis as well as in the maintenance of the motor system, making them an ideal in vivo model system to study the complex biology of TDP-43.PMID:38367882 | DOI:10.1016/j.nbd.2024.106437 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 17, 2024 Category: Neurology Authors: Juan M Godoy-Corchuelo Zeinab Ali Jose M Brito Armas Aurea B Martins-Bach Irene Garc ía-Toledo Luis C Fern ández-Beltrán Juan I L ópez-Carbonero Pablo Bascu ñana Shoshana Spring Irene Jimenez-Coca Ram ón A Muñoz de Bustillo Alfaro Maria J S ánchez Source Type: research
Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease
Neurobiol Dis. 2024 Feb 14:106438. doi: 10.1016/j.nbd.2024.106438. Online ahead of print.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD. The identification of sensitive white-matter-based biomarkers in HD animal models will be important in understanding disease mechanisms and testing the efficacy of therapeutic interventions. Here we investigated the progression of white matter deficits in the knock-in zQ175DN heterozygous (HET) mouse model of HD at 3, 6 and...
Source: Neurobiology of Disease - February 16, 2024 Category: Neurology Authors: Nicholas Vidas-Guscic Jo ëlle van Rijswijk Johan Van Audekerke Ben Jeurissen Israel Nnah Haiying Tang Ignacio Munoz-Sanjuan Dorian Pustina Roger Cachope Annemie Van der Linden Daniele Bertoglio Marleen Verhoye Source Type: research
Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET
In conclusion, increased local diffusivity was detected in cognitively unimpaired APOE4/4 homozygotes compared to APOE3/4 and APOE3/3 carriers and increased diffusivity correlated with biomarkers of Alzheimer's disease and neurodegeneration. White matter impairment seems to be an early phenomenon in the Alzheimer's disease pathologic process in APOE4/4 homozygotes.PMID:38365046 | DOI:10.1016/j.nbd.2024.106439 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 16, 2024 Category: Neurology Authors: Claudia Tato-Fern ández Laura L Ekblad Elina Pietil ä Virva Saunavaara Semi Helin Riitta Parkkola Henrik Zetterberg Kaj Blennow Juha O Rinne Anniina Snellman Source Type: research
Navigating the future of retinitis pigmentosa treatments: A comprehensive analysis of therapeutic approaches in rd10 mice
Neurobiol Dis. 2024 Feb 8:106436. doi: 10.1016/j.nbd.2024.106436. Online ahead of print.ABSTRACTRetinitis pigmentosa (RP) is a degenerative disease, caused by genetic mutations that lead to a loss in photoreceptors. For research on RP, rd10 mice, which carry mutations in the phosphodiesterase (PDE) gene, exhibit degenerative patterns comparable to those of patients with RP, making them an ideal model for investigating potential treatments. Although numerous studies have reported the potential of biochemical drugs, gene correction, and stem cell transplantation in decelerating rd10 retinal degeneration, a comprehensive revi...
Source: Neurobiology of Disease - February 10, 2024 Category: Neurology Authors: Yang Hongli Zhang Hui Li Xiaorong Source Type: research
NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1
We report that NLRP6 is abundantly expressed in microglia and significantly upregulated in the ischemic brain. The brain injury severity was alleviated in NLRP6-deficient mice after ischemic stroke, as evidenced by reduced cerebral infarct volume, decreased neurological deficit scores, improved histopathological morphological changes, ameliorated neuronal denaturation, and relief of sensorimotor dysfunction. In the co-culture OGD/R model, NLRP6 deficiency prevented neuronal death and attenuated microglial cell injury. NLRP6 deficiency blocked several NLRs inflammasomes' activation and abrogated inflammasome-related cytokin...
Source: Neurobiology of Disease - February 10, 2024 Category: Neurology Authors: Qi He Changchang Meng Mengjie Jia Junyi Tan Keli Huang Hui Gan Lingyu Li Jing Zhao Source Type: research
Navigating the future of retinitis pigmentosa treatments: A comprehensive analysis of therapeutic approaches in rd10 mice
Neurobiol Dis. 2024 Feb 8:106436. doi: 10.1016/j.nbd.2024.106436. Online ahead of print.ABSTRACTRetinitis pigmentosa (RP) is a degenerative disease, caused by genetic mutations that lead to a loss in photoreceptors. For research on RP, rd10 mice, which carry mutations in the phosphodiesterase (PDE) gene, exhibit degenerative patterns comparable to those of patients with RP, making them an ideal model for investigating potential treatments. Although numerous studies have reported the potential of biochemical drugs, gene correction, and stem cell transplantation in decelerating rd10 retinal degeneration, a comprehensive revi...
Source: Neurobiology of Disease - February 10, 2024 Category: Neurology Authors: Yang Hongli Zhang Hui Li Xiaorong Source Type: research
NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1
We report that NLRP6 is abundantly expressed in microglia and significantly upregulated in the ischemic brain. The brain injury severity was alleviated in NLRP6-deficient mice after ischemic stroke, as evidenced by reduced cerebral infarct volume, decreased neurological deficit scores, improved histopathological morphological changes, ameliorated neuronal denaturation, and relief of sensorimotor dysfunction. In the co-culture OGD/R model, NLRP6 deficiency prevented neuronal death and attenuated microglial cell injury. NLRP6 deficiency blocked several NLRs inflammasomes' activation and abrogated inflammasome-related cytokin...
Source: Neurobiology of Disease - February 10, 2024 Category: Neurology Authors: Qi He Changchang Meng Mengjie Jia Junyi Tan Keli Huang Hui Gan Lingyu Li Jing Zhao Source Type: research
Navigating the future of retinitis pigmentosa treatments: A comprehensive analysis of therapeutic approaches in rd10 mice
Neurobiol Dis. 2024 Feb 8:106436. doi: 10.1016/j.nbd.2024.106436. Online ahead of print.ABSTRACTRetinitis pigmentosa (RP) is a degenerative disease, caused by genetic mutations that lead to a loss in photoreceptors. For research on RP, rd10 mice, which carry mutations in the phosphodiesterase (PDE) gene, exhibit degenerative patterns comparable to those of patients with RP, making them an ideal model for investigating potential treatments. Although numerous studies have reported the potential of biochemical drugs, gene correction, and stem cell transplantation in decelerating rd10 retinal degeneration, a comprehensive revi...
Source: Neurobiology of Disease - February 10, 2024 Category: Neurology Authors: Yang Hongli Zhang Hui Li Xiaorong Source Type: research
NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1
We report that NLRP6 is abundantly expressed in microglia and significantly upregulated in the ischemic brain. The brain injury severity was alleviated in NLRP6-deficient mice after ischemic stroke, as evidenced by reduced cerebral infarct volume, decreased neurological deficit scores, improved histopathological morphological changes, ameliorated neuronal denaturation, and relief of sensorimotor dysfunction. In the co-culture OGD/R model, NLRP6 deficiency prevented neuronal death and attenuated microglial cell injury. NLRP6 deficiency blocked several NLRs inflammasomes' activation and abrogated inflammasome-related cytokin...
Source: Neurobiology of Disease - February 10, 2024 Category: Neurology Authors: Qi He Changchang Meng Mengjie Jia Junyi Tan Keli Huang Hui Gan Lingyu Li Jing Zhao Source Type: research
Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1 < sup > G93A < /sup > mice
Neurobiol Dis. 2024 Feb 7:106435. doi: 10.1016/j.nbd.2024.106435. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, closely linked to the loss/gain of astrocytic function. Using the ALS SOD1G93A mice, we investigated the astrocytic contribution for the electrophysiological alterations observed in the M1 of SOD1G93A mice, throughout disease progression. Results showed that astrocytes are involved i...
Source: Neurobiology of Disease - February 9, 2024 Category: Neurology Authors: Sara Costa-Pinto Joana Gon çalves-Ribeiro Joana Tedim-Moreira Renato Socodato Jo ão B Relvas Ana M Sebasti ão Sandra H Vaz Source Type: research
Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice
Neurobiol Dis. 2024 Feb 7;192:106431. doi: 10.1016/j.nbd.2024.106431. Online ahead of print.ABSTRACTMutations of the human TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9 (TRAPPC9) cause a neurodevelopmental disorder characterised by microcephaly and intellectual disability. Trappc9 constitutes a subunit specific to the intracellular membrane-associated TrappII complex. The TrappII complex interacts with Rab11 and Rab18, the latter being specifically associated with lipid droplets (LDs). Here we used non-invasive imaging to characterise Trappc9 knock-out (KO) mice as a model of the human hereditary disorder. KOs developed p...
Source: Neurobiology of Disease - February 8, 2024 Category: Neurology Authors: Sultan Aljuraysi Mark Platt Michela Pulix Harish Poptani Antonius Plagge Source Type: research
P2X7 receptor of olfactory bulb microglia plays a pathogenic role in stress-related depression in mice with allergic rhinitis
Neurobiol Dis. 2024 Feb 6;192:106432. doi: 10.1016/j.nbd.2024.106432. Online ahead of print.ABSTRACTThe aim of this study was to explore the role and mechanism of the olfactory bulb (OB) microglial P2X7 receptor (P2X7R) in allergic rhinitis (AR)-related depression, with the objective of identifying a potential clinical target. An AR mouse model was induced using ovalbumin (OVA), while chronic stress was employed to induce depression. The study used P2X7R-specific antagonists and OB microglia-specific P2X7R knockdown mice as crucial tools. The results showed that mice in the OVA + stress group exhibited more pronounced depr...
Source: Neurobiology of Disease - February 8, 2024 Category: Neurology Authors: Yakui Mou Caiyu Sun Shizhuang Wei Xiaoyu Song Hanrui Wang Yao Wang Chao Ren Xicheng Song Source Type: research
The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle
Neurobiol Dis. 2024 Feb 7;192:106426. doi: 10.1016/j.nbd.2024.106426. Online ahead of print.ABSTRACTThe term "glymphatic" emerged roughly a decade ago, marking a pivotal point in neuroscience research. The glymphatic system, a glial-dependent perivascular network distributed throughout the brain, has since become a focal point of investigation. There is increasing evidence suggesting that impairment of the glymphatic system appears to be a common feature of neurodegenerative disorders, and this impairment exacerbates as disease progression. Nevertheless, the common factors contributing to glymphatic system dysfunction acro...
Source: Neurobiology of Disease - February 8, 2024 Category: Neurology Authors: Yu Cai Yangqiqi Zhang Shuo Leng Yuanyuan Ma Quan Jiang Qiuting Wen Shenghong Ju Jiani Hu Source Type: research
