Depression-like phenotypes in mice following common bile duct ligation: Insights into the gut-liver-brain axis via the vagus nerve
This study explored the potential role of the gut-liver-brain axis via the vagus nerve in depression-like phenotypes in mice with liver cirrhosis. These mice underwent common bile duct ligation (CBDL), a method used to stimulate liver cirrhosis. To assess depression-like behaviors, behavioral tests were conducted 10 days following either sham or CBDL surgeries. The mice with CBDL displayed symptoms such as splenomegaly, elevated plasma levels of interleukin-6 and tumor necrosis factor-α, depression-like behaviors, decreased levels of synaptic proteins in the prefrontal cortex (PFC), disrupted gut microbiota balance, and c...
Source: Neurobiology of Disease - February 8, 2024 Category: Neurology Authors: Yong Yang Akifumi Eguchi Chisato Mori Kenji Hashimoto Source Type: research
Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis
Neurobiol Dis. 2024 Feb 5;192:106430. doi: 10.1016/j.nbd.2024.106430. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different post-translational modifications leading to a loss of function in the nucleus and an increase in toxicity in the cytoplasm. Previous reports have indicated that pathogenic TDP-43 exhibits prion-like propagation in various contexts. With the aim of advancing therapeutics focused on preventing the propagation of TDP-43 pathology, we studied the ...
Source: Neurobiology of Disease - February 7, 2024 Category: Neurology Authors: Eva P Cuevas Loreto Martinez-Gonzalez Clara Gordillo Carlota Tosat-Bitri án Carmen P érez de la Lastra Amets S áenz Carmen Gil Valle Palomo Ángeles Martin-Requero Ana Martinez Source Type: research
Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome
In this study, we compared Dp1Tyb mice, a DS model, against their wild-type (WT) littermates of both sexes to investigate the impact of DS-related genetic abnormalities on the brain phenotype. We performed in vivo whole brain magnetic resonance imaging (MRI) and hippocampal 1H magnetic resonance spectroscopy (MRS) on the animals at 3 months of age. Subsequently, ex vivo MRI scans and histological analyses were conducted post-mortem. Our findings unveiled the following neuroanatomical and biochemical alterations in the Dp1Tyb brains: a smaller surface area and a rounder shape compared to WT brains, with DS males also presen...
Source: Neurobiology of Disease - February 6, 2024 Category: Neurology Authors: Maria Elisa Serrano Eugene Kim Bernard Siow Da Ma Loreto Rojo Camilla Simmons Darryl Hayward Dorota Gibbins Nisha Singh Andre Strydom Elizabeth M C Fisher Victor L J Tybulewicz Diana Cash Source Type: research
The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice
Neurobiol Dis. 2024 Feb 2;192:106429. doi: 10.1016/j.nbd.2024.106429. Online ahead of print.ABSTRACTThe most prominent symptom of Alzheimer's disease (AD) is cognitive decline; however, sleep and other circadian disruptions are also common in AD patients. Sleep disruptions have been connected with memory problems and therefore the changes in sleep patterns observed in AD patients may also actively contribute to cognitive decline. However, the underlying molecular mechanisms that connect sleep disruptions and AD are unclear. A characteristic feature of AD is the formation of plaques consisting of Amyloid-β (Aβ) peptides g...
Source: Neurobiology of Disease - February 3, 2024 Category: Neurology Authors: Dani M Long Olga Cravetchi Eileen S Chow Charles Allen Doris Kretzschmar Source Type: research
A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease
Neurobiol Dis. 2024 Feb 1;192:106427. doi: 10.1016/j.nbd.2024.106427. Online ahead of print.ABSTRACTTransgenic models of familial Alzheimer's disease (AD) serve as valuable tools for probing the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this meta-analysis, we sought to evaluate levels of phosphorylated tau (p-tau) and explore potential age-related variations in tau hyperphosphorylation, within mouse models of AD. The PubMed and Scopus databases were searched for studies measuring soluble p-tau in 5xFAD, APPswe/PSEN1de9, J20 and APP23 mice. Data were extracted and analyzed using standardi...
Source: Neurobiology of Disease - February 2, 2024 Category: Neurology Authors: Malamati Kourti Athanasios Metaxas Source Type: research
TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms
Neurobiol Dis. 2024 Feb 1;192:106428. doi: 10.1016/j.nbd.2024.106428. Online ahead of print.ABSTRACTThe heart and brain are the core organs of the circulation and central nervous system, respectively, and play an important role in maintaining normal physiological functions. Early neuronal and cardiac damage affects organ function. The relationship between the heart and brain is being continuously investigated. Evidence-based medicine has revealed the concept of the "heart- brain axis," which may provide new therapeutic strategies for certain diseases. Takeda protein-coupled receptor 5 (TGR5) is a metabolic regulator involv...
Source: Neurobiology of Disease - February 2, 2024 Category: Neurology Authors: Nan Xu Yufeng He Chunyu Zhang Yongqiang Zhang Shengjie Cheng Li Deng Yi Zhong Bin Liao Yan Wei Jian Feng Source Type: research
Altered static and dynamic functional connectivity of the default mode network across epilepsy subtypes in children: A resting-state fMRI study
CONCLUSIONS: Our findings highlight both shared and distinct FC alterations within the DMN in children with different types of epilepsy. Furthermore, our work provides a novel perspective on the functional alterations in the DMN of pediatric patients, suggesting that combined sFC and dFC analysis can provide valuable insights for deepening our understanding of the neuronal mechanism underlying epilepsy in children.PMID:38296113 | DOI:10.1016/j.nbd.2024.106425 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 31, 2024 Category: Neurology Authors: Yongxin Li Yun Ran Maohua Yao Qian Chen Source Type: research
Astrocyte-derived lactate in stress disorders
Neurobiol Dis. 2024 Jan 29;192:106417. doi: 10.1016/j.nbd.2024.106417. Online ahead of print.ABSTRACTStress disorders are psychiatric disorders arising following stressful or traumatic events. They could deleteriously affect an individual's health because they often co-occur with mental illnesses. Considerable attention has been focused on neurons when considering the neurobiology of stress disorders. However, like other mental health conditions, recent studies have highlighted the importance of astrocytes in the pathophysiology of stress-related disorders. In addition to their structural and homeostatic support role, astr...
Source: Neurobiology of Disease - January 31, 2024 Category: Neurology Authors: Farah Chamaa Pierre J Magistretti Hubert Fiumelli Source Type: research
Low-frequency stimulation in the zona incerta attenuates seizure via driving GABAergic neuronal activity
CONCLUSION: Our results demonstrate that low-frequency DBS in the ZI attenuates seizure via driving GABAergic neuronal activity. This suggests that the ZI represents a potential DBS target for treating both hippocampal and cortical seizure through the activation of GABAergic neurons, thereby holding therapeutic significance for seizure treatment.PMID:38290566 | DOI:10.1016/j.nbd.2024.106424 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 30, 2024 Category: Neurology Authors: Mengdi Zhang Lin Yang Zhongxia Li Fan Fei Yuan Zhou Dongxiao Jiang Yuyi Zheng Hui Cheng Yu Wang Cenglin Xu Jiajia Fang Shuang Wang Zhong Chen Yi Wang Source Type: research
Trimethylamine-N-oxide and cerebral stroke risk: A review
Neurobiol Dis. 2024 Jan 28;192:106423. doi: 10.1016/j.nbd.2024.106423. Online ahead of print.ABSTRACTTrimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced by the action of gut microbiota and the hepatic enzyme Flavin Mono‑oxygenase 3 (FMO3). TMAO level has a positive correlation with the risk of cardiovascular events, including stroke, and their level is influenced mainly by dietary choice and the action of liver enzyme FMO3. TMAO plays a role in the development of atherosclerosis plaque, which is one of the causative factors of the stroke event. Preclinical and clinical investigations on the TMAO...
Source: Neurobiology of Disease - January 29, 2024 Category: Neurology Authors: Phurbu Dolkar Tenzin Deyang Nikhilesh Anand Annan Gopinath Rathipriya Tousif Ahmed Hediyal Vichitra Chandrasekaran Naveen Kumar Krishnamoorthy Vasavi Rakesh Gorantla Muhammed Bishir Luay Rashan Sulie L Chang Meena Kishore Sakharkar Jian Yang Saravana Babu Source Type: research
Cyclin F can alter the turnover of TDP-43
This study provides greater insights into the interaction that occurs between cyclin F and TDP-43 in cells and in vivo.PMID:38286389 | DOI:10.1016/j.nbd.2024.106421 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 29, 2024 Category: Neurology Authors: Stephanie L Rayner Alison Hogan Jennilee M Davidson Tyler Chapman Flora Cheng Luan Luu Sharlynn Wu Selina Zhang Shu Yang Ian Blair Marco Morsch Roger Chung Albert Lee Source Type: research
Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice
Neurobiol Dis. 2024 Jan 28;192:106422. doi: 10.1016/j.nbd.2024.106422. Online ahead of print.ABSTRACTGait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor control in health and disease remain obfuscated. We aimed to describe the effect of gradual adult-onset Purkinje cell degeneration on gaiting patterns in mice, and to determine whether two different mechanisms that both lead to Purkinje cell degeneration cause different patter...
Source: Neurobiology of Disease - January 29, 2024 Category: Neurology Authors: Dick Jaarsma Maria B Birkisd óttir Randy van Vossen Demi W G D Oomen Oussama Akhiyat Wilbert P Vermeij Sebastiaan K E Koekkoek Chris I De Zeeuw Laurens W J Bosman Source Type: research
The gut-brain axis: Correlation of choroid plexus volume and permeability with inflammatory biomarkers in Crohn's disease
CONCLUSIONS: Inflammatory activity in patients with CD is associated with changes in CP volume and permeability, thus supporting the hypothesis that intestinal inflammation could affect the brain through the modulation of CP vascular barrier also in humans.PMID:38272141 | DOI:10.1016/j.nbd.2024.106416 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 25, 2024 Category: Neurology Authors: Cristiana Bonifacio Giovanni Savini Christian Reca Federico Garoli Riccardo Levi Giulia Vatteroni Luca Balzarini Mariangela Allocca Federica Furfaro Arianna Dal Buono Alessandro Armuzzi Silvio Danese Michela Matteoli Maria Rescigno Gionata Fiorino Letteri Source Type: research
Exo-miR-144-3p as a promising diagnostic biomarker for depressive symptoms in heart failure
CONCLUSIONS: In this study, we examined the serum exosomal miRNA expression profiles of HF patients with depressive symptoms and found that lower level of exo-miR-144-3p was associated with more severe depressive symptoms. Exo-miR-144-3p is a potential biomarker for the diagnosis of HF-DS.PMID:38266934 | DOI:10.1016/j.nbd.2024.106415 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 24, 2024 Category: Neurology Authors: Ruting Wang Kai Huang Yuehua Feng Jiahao Duan Hangfeng Ying Qianyuan Shi Yi Zhang Riyue Jiang Ling Yang Source Type: research
Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease
Neurobiol Dis. 2024 Jan 20;192:106413. doi: 10.1016/j.nbd.2024.106413. Online ahead of print.ABSTRACTWe recently described increased D- and L-serine concentrations in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, the post-mortem caudate-putamen of human Parkinson's disease (PD) brains and the cerebrospinal fluid (CSF) of de novo living PD patients. However, data regarding blood D- and L-serine levels in PD are scarce. Here, we investigated whether the serum profile of D- and L-serine, as well as the other glutamate N-methyl-D-aspartate ionotropic receptor (NMDAR)-related amino acids, ...
Source: Neurobiology of Disease - January 22, 2024 Category: Neurology Authors: Alberto Imarisio Isar Yahyavi Micol Avenali Anna Di Maio Gabriele Buongarzone Caterina Galandra Marta Picascia Asia Filosa Clara Gasparri Maria Cristina Monti Mariangela Rondanelli Claudio Pacchetti Francesco Errico Enza Maria Valente Alessandro Usiello Source Type: research
