Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
Neurobiol Dis. 2023 Dec 26:106393. doi: 10.1016/j.nbd.2023.106393. Online ahead of print.ABSTRACTPhosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacol...
Source: Neurobiology of Disease - December 28, 2023 Category: Neurology Authors: S ébastien Delhaye Marielle Jarjat Asma Boulksibat Clara Sanchez Alessandra Tempio Andrei Turtoi Mauro Giorgi Sandra Lacas-Gervais Gabriele Baj Carole Rovere Viviana Trezza Manuela Pellegrini Thomas Maurin Enzo Lalli Barbara Bardoni Source Type: research
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress
Neurobiol Dis. 2023 Dec 23;190:106391. doi: 10.1016/j.nbd.2023.106391. Online ahead of print.ABSTRACTCGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is known about the factors governing polyG IIs formation as well as its molecular pathogenesis. Considering that neurogenetic disorders usually involve interactions between genetic and environmental stresses, we investigated the effect ...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Hui Wang Yilei Zheng Jiaxi Yu Lingchao Meng Wei Zhang Daojun Hong Zhaoxia Wang Yun Yuan Jianwen Deng Source Type: research
Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis
This study provides compelling evidence to suggest that choline metabolism plays a crucial role in the development and treatment of mood disorders in IBD. Choline and its metabolites appear to have a significant role in maintaining the stability of the GBA.PMID:38145852 | DOI:10.1016/j.nbd.2023.106390 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Fan Zhang Lingnan Guo Jingjing Shi Hao Jiang Feini Zhou Yanlin Zhou Bin Lv Maosheng Xu Source Type: research
Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
Neurobiol Dis. 2023 Dec 23:106392. doi: 10.1016/j.nbd.2023.106392. Online ahead of print.ABSTRACTHaving experienced stress during sensitive periods of brain development strongly influences how individuals cope with later stress. Some are prone to develop anxiety or depression, while others appear resilient. The as-yet-unknown mechanisms underlying these differences may lie in how genes and environmental stress interact to shape the circuits that control emotions. Here, we investigated the role of the habenulo-interpeduncular system (HIPS), a critical node in reward circuits, in early stress-induced anxiety in mice. We foun...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Malalaniaina Rakotobe Niels Fjerdingstad Nuria Ruiz-Reig Thomas Lamonerie Fabien D'Autr éaux Source Type: research
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress
Neurobiol Dis. 2023 Dec 23:106391. doi: 10.1016/j.nbd.2023.106391. Online ahead of print.ABSTRACTCGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is known about the factors governing polyG IIs formation as well as its molecular pathogenesis. Considering that neurogenetic disorders usually involve interactions between genetic and environmental stresses, we investigated the effect of s...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Hui Wang Yilei Zheng Jiaxi Yu Lingchao Meng Wei Zhang Daojun Hong Zhaoxia Wang Yun Yuan Jianwen Deng Source Type: research
Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis
This study provides compelling evidence to suggest that choline metabolism plays a crucial role in the development and treatment of mood disorders in IBD. Choline and its metabolites appear to have a significant role in maintaining the stability of the GBA.PMID:38145852 | DOI:10.1016/j.nbd.2023.106390 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Fan Zhang Lingnan Guo Jingjing Shi Hao Jiang Feini Zhou Yanlin Zhou Bin Lv Maosheng Xu Source Type: research
Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
Neurobiol Dis. 2023 Dec 23:106392. doi: 10.1016/j.nbd.2023.106392. Online ahead of print.ABSTRACTHaving experienced stress during sensitive periods of brain development strongly influences how individuals cope with later stress. Some are prone to develop anxiety or depression, while others appear resilient. The as-yet-unknown mechanisms underlying these differences may lie in how genes and environmental stress interact to shape the circuits that control emotions. Here, we investigated the role of the habenulo-interpeduncular system (HIPS), a critical node in reward circuits, in early stress-induced anxiety in mice. We foun...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Malalaniaina Rakotobe Niels Fjerdingstad Nuria Ruiz-Reig Thomas Lamonerie Fabien D'Autr éaux Source Type: research
Pathologic changes in neuronal intranuclear inclusion disease are linked to aberrant FUS interaction under hyperosmotic stress
Neurobiol Dis. 2023 Dec 23:106391. doi: 10.1016/j.nbd.2023.106391. Online ahead of print.ABSTRACTCGG repeat expansion in NOTCH2NLC is the genetic cause of neuronal intranuclear inclusion disease (NIID). Previous studies indicated that the CGG repeats can be translated into polyglycine protein (N2CpolyG) which was toxic to neurons by forming intranuclear inclusions (IIs). However, little is known about the factors governing polyG IIs formation as well as its molecular pathogenesis. Considering that neurogenetic disorders usually involve interactions between genetic and environmental stresses, we investigated the effect of s...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Hui Wang Yilei Zheng Jiaxi Yu Lingchao Meng Wei Zhang Daojun Hong Zhaoxia Wang Yun Yuan Jianwen Deng Source Type: research
Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis
This study provides compelling evidence to suggest that choline metabolism plays a crucial role in the development and treatment of mood disorders in IBD. Choline and its metabolites appear to have a significant role in maintaining the stability of the GBA.PMID:38145852 | DOI:10.1016/j.nbd.2023.106390 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Fan Zhang Lingnan Guo Jingjing Shi Hao Jiang Feini Zhou Yanlin Zhou Bin Lv Maosheng Xu Source Type: research
Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
Neurobiol Dis. 2023 Dec 23:106392. doi: 10.1016/j.nbd.2023.106392. Online ahead of print.ABSTRACTHaving experienced stress during sensitive periods of brain development strongly influences how individuals cope with later stress. Some are prone to develop anxiety or depression, while others appear resilient. The as-yet-unknown mechanisms underlying these differences may lie in how genes and environmental stress interact to shape the circuits that control emotions. Here, we investigated the role of the habenulo-interpeduncular system (HIPS), a critical node in reward circuits, in early stress-induced anxiety in mice. We foun...
Source: Neurobiology of Disease - December 25, 2023 Category: Neurology Authors: Malalaniaina Rakotobe Niels Fjerdingstad Nuria Ruiz-Reig Thomas Lamonerie Fabien D'Autr éaux Source Type: research
Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease
Neurobiol Dis. 2023 Dec 22:106389. doi: 10.1016/j.nbd.2023.106389. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disease which accounts for the most cases of dementia worldwide. Impaired memory, including acquisition, consolidation, and retrieval, is one of the hallmarks in AD. At the cellular level, dysregulated synaptic plasticity partly due to reduced long-term potentiation (LTP) and enhanced long-term depression (LTD) underlies the memory deficits in AD. GluA3 containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are one of key receptors involved...
Source: Neurobiology of Disease - December 24, 2023 Category: Neurology Authors: Tong Zhang Amalia M Dolga Ulrich L M Eisel Martina Schmidt Source Type: research
The mitochondriogenic but not the immunosuppressant effects of mTOR inhibitors prompt neuroprotection and delay disease evolution in a mouse model of progressive multiple sclerosis
DISCUSSION: Data corroborate the key role of mitochondriogenesis to treatment of MS progression, and for the first time disclose the translational potential of mTOR inhibitors in PMS therapy.PMID:38142841 | DOI:10.1016/j.nbd.2023.106387 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 24, 2023 Category: Neurology Authors: Daniela Buonvicino Sara Pratesi Giuseppe Ranieri Alessandra Pistolesi Daniele Guasti Alberto Chiarugi Source Type: research
Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes
CONCLUSION: Overall, we qualified MLC1 as a Ca2+ sensitive protein involved in the control of volume changes in response to ER Ca2+ release and astrocyte activation. These findings provide new insights for the comprehension of the molecular mechanisms underlining brain edema and myelin degeneration characterizing MLC and other LD where astrocytes have a primary role in the pathological process.PMID:38141856 | DOI:10.1016/j.nbd.2023.106388 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 23, 2023 Category: Neurology Authors: M S Brignone A Lanciotti P Molinari C Mallozzi C De Nuccio E S Caprini T C Petrucci S Visentin E Ambrosini Source Type: research
Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes
CONCLUSION: Overall, we qualified MLC1 as a Ca2+ sensitive protein involved in the control of volume changes in response to ER Ca2+ release and astrocyte activation. These findings provide new insights for the comprehension of the molecular mechanisms underlining brain edema and myelin degeneration characterizing MLC and other LD where astrocytes have a primary role in the pathological process.PMID:38141856 | DOI:10.1016/j.nbd.2023.106388 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 23, 2023 Category: Neurology Authors: M S Brignone A Lanciotti P Molinari C Mallozzi C De Nuccio E S Caprini T C Petrucci S Visentin E Ambrosini Source Type: research
Subthalamic and pallidal neurons are modulated during externally cued movements in Parkinson's disease
Neurobiol Dis. 2023 Dec 20:106384. doi: 10.1016/j.nbd.2023.106384. Online ahead of print.ABSTRACTExternal sensory cues can reduce freezing of gait in people with Parkinson's disease (PD), yet the role of the basal ganglia in these movements is unclear. We used microelectrode recordings to examine modulations in single unit (SU) and oscillatory local field potentials (LFP) during auditory-cued rhythmic pedaling movements of the feet. We tested five blocks of increasing cue frequencies (1 Hz, 1.5 Hz, 2 Hz, 2.5 Hz, and 3 Hz) in 24 people with PD undergoing deep brain stimulation surgery of the subthalamic nucleus (STN) or glo...
Source: Neurobiology of Disease - December 22, 2023 Category: Neurology Authors: Stephanie Tran Tjitske C Heida Janne J A Heijs Tameem Al-Ozzi Srdjan Sumarac Frhan I Alanazi Suneil K Kalia Mojgan Hodaie Andres M Lozano Luka Milosevic R Chen William D Hutchison Source Type: research
