Differential profiles of serum cytokines in Parkinson's disease according to disease duration
CONCLUSIONS: Our findings suggest that a pro-inflammatory status may be observed in PD patients in the early phases of the disease, independently from age.PMID:38061398 | DOI:10.1016/j.nbd.2023.106371 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 7, 2023 Category: Neurology Authors: Giulia Di Lazzaro Anna Picca Sofia Boldrini Francesco Bove Emanuele Marzetti Martina Petracca Carla Piano Anna Rita Bentivoglio Paolo Calabresi Source Type: research
The effects of P2 segment of posterior cerebral artery to thalamus blood supply pattern on gait in cerebral small vessel disease: A 7 T MRI based study
Neurobiol Dis. 2023 Dec 5:106372. doi: 10.1016/j.nbd.2023.106372. Online ahead of print.ABSTRACTGait disturbance is a manifestation of cerebral small vessel disease (CSVD). The posterolateral thalamus (PL), whose blood is mainly supplied by the P2 segment of posterior cerebral artery (P2-PCA), plays pivotal roles in gait regulation. We investigated the influence of the distance between P2-PCA and PL on gait with varying CSVD burden. 71 participants were divided into low and high CSVD burden groups. The distance from P2-PCA to PL was measured using 7 T TOF-MRA and categorized into an immediate or distant PCA-to-thalamus pat...
Source: Neurobiology of Disease - December 7, 2023 Category: Neurology Authors: Cen Guo Bei Wang Yajing Huo Lili Shan Tianci Qiao Zidong Yang Mingyuan Liu Yilin Wang Guanshu Liu Yajie Liu He Wang Yan Han Source Type: research
Differential profiles of serum cytokines in Parkinson's disease according to disease duration
CONCLUSIONS: Our findings suggest that a pro-inflammatory status may be observed in PD patients in the early phases of the disease, independently from age.PMID:38061398 | DOI:10.1016/j.nbd.2023.106371 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - December 7, 2023 Category: Neurology Authors: Giulia Di Lazzaro Anna Picca Sofia Boldrini Francesco Bove Emanuele Marzetti Martina Petracca Carla Piano Anna Rita Bentivoglio Paolo Calabresi Source Type: research
Predicting neurodegeneration from sleep related biofluid changes
Neurobiol Dis. 2023 Dec 2:106369. doi: 10.1016/j.nbd.2023.106369. Online ahead of print.ABSTRACTSleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potentially either representing an early stage of the disease itself or acting as a pathophysiological driver. Therefore, discovering biomarkers that identify individuals with sleep-wake disturbances who are at risk of developing neurodegenerative diseases will allow early diagnosis and intervention. Given the association between sleep and neurodegeneration, the most frequently analyzed fluid biomarkers in people w...
Source: Neurobiology of Disease - December 4, 2023 Category: Neurology Authors: Yue Yang Woojin Scott Kim Johannes C Michaelian Simon J G Lewis Craig L Phillips Angela L D'Rozario Pratishtha Chatterjee Ralph N Martins Ron Grunstein Glenda M Halliday Sharon L Naismith Source Type: research
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
Neurobiol Dis. 2023 Dec 2;190:106370. doi: 10.1016/j.nbd.2023.106370. Online ahead of print.ABSTRACTAfter spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrophage phenotype in vitro revealed a pro-inflammatory profile, increased reactive oxygen species (ROS) production, and mitochondrial dysfunction. Bioinformatic analysis identified PI3K as a regulator of inflammation in foamy macrophages, and inhibition of this pathway decreased the...
Source: Neurobiology of Disease - December 4, 2023 Category: Neurology Authors: Christine B Ryan James S Choi Brian Kang Seth Herr Claudia Pereira Carlos T Moraes Hassan Al-Ali Jae K Lee Source Type: research
Predicting neurodegeneration from sleep related biofluid changes
Neurobiol Dis. 2023 Dec 2:106369. doi: 10.1016/j.nbd.2023.106369. Online ahead of print.ABSTRACTSleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potentially either representing an early stage of the disease itself or acting as a pathophysiological driver. Therefore, discovering biomarkers that identify individuals with sleep-wake disturbances who are at risk of developing neurodegenerative diseases will allow early diagnosis and intervention. Given the association between sleep and neurodegeneration, the most frequently analyzed fluid biomarkers in people w...
Source: Neurobiology of Disease - December 4, 2023 Category: Neurology Authors: Yue Yang Woojin Scott Kim Johannes C Michaelian Simon J G Lewis Craig L Phillips Angela L D'Rozario Pratishtha Chatterjee Ralph N Martins Ron Grunstein Glenda M Halliday Sharon L Naismith Source Type: research
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
Neurobiol Dis. 2023 Dec 2:106370. doi: 10.1016/j.nbd.2023.106370. Online ahead of print.ABSTRACTAfter spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrophage phenotype in vitro revealed a pro-inflammatory profile, increased reactive oxygen species (ROS) production, and mitochondrial dysfunction. Bioinformatic analysis identified PI3K as a regulator of inflammation in foamy macrophages, and inhibition of this pathway decreased their l...
Source: Neurobiology of Disease - December 4, 2023 Category: Neurology Authors: Christine B Ryan James S Choi Brian Kang Seth Herr Claudia Pereira Carlos T Moraes Hassan Al-Ali Jae K Lee Source Type: research
Predicting neurodegeneration from sleep related biofluid changes
Neurobiol Dis. 2023 Dec 2:106369. doi: 10.1016/j.nbd.2023.106369. Online ahead of print.ABSTRACTSleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potentially either representing an early stage of the disease itself or acting as a pathophysiological driver. Therefore, discovering biomarkers that identify individuals with sleep-wake disturbances who are at risk of developing neurodegenerative diseases will allow early diagnosis and intervention. Given the association between sleep and neurodegeneration, the most frequently analyzed fluid biomarkers in people w...
Source: Neurobiology of Disease - December 4, 2023 Category: Neurology Authors: Yue Yang Woojin Scott Kim Johannes C Michaelian Simon J G Lewis Craig L Phillips Angela L D'Rozario Pratishtha Chatterjee Ralph N Martins Ron Grunstein Glenda M Halliday Sharon L Naismith Source Type: research
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
Neurobiol Dis. 2023 Dec 2:106370. doi: 10.1016/j.nbd.2023.106370. Online ahead of print.ABSTRACTAfter spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrophage phenotype in vitro revealed a pro-inflammatory profile, increased reactive oxygen species (ROS) production, and mitochondrial dysfunction. Bioinformatic analysis identified PI3K as a regulator of inflammation in foamy macrophages, and inhibition of this pathway decreased their l...
Source: Neurobiology of Disease - December 4, 2023 Category: Neurology Authors: Christine B Ryan James S Choi Brian Kang Seth Herr Claudia Pereira Carlos T Moraes Hassan Al-Ali Jae K Lee Source Type: research
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
Neurobiol Dis. 2023 Nov 30:106367. doi: 10.1016/j.nbd.2023.106367. Online ahead of print.ABSTRACTX-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within intron 32 of TATA-binding protein associated factor 1 (TAF1) that causes an alteration of TAF1 splicing, partial intron retention, and decreased transcription. Although TAF1 is expressed in all organs, medium spiny neurons (MSNs) within the striatum are one of the cell types most affected in XDP. To define how mutations in the TAF1 gen...
Source: Neurobiology of Disease - December 2, 2023 Category: Neurology Authors: Kizito-Tshitoko Tshilenge Joanna Bons Carlos Galicia Aguirre Cristian Geronimo-Olvera Samah Shah Jacob Rose Akos A Gerencser Sally K Mak Michelle E Ehrlich D Cristopher Bragg Birgit Schilling Lisa M Ellerby Source Type: research
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
Neurobiol Dis. 2023 Nov 30:106367. doi: 10.1016/j.nbd.2023.106367. Online ahead of print.ABSTRACTX-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within intron 32 of TATA-binding protein associated factor 1 (TAF1) that causes an alteration of TAF1 splicing, partial intron retention, and decreased transcription. Although TAF1 is expressed in all organs, medium spiny neurons (MSNs) within the striatum are one of the cell types most affected in XDP. To define how mutations in the TAF1 gen...
Source: Neurobiology of Disease - December 2, 2023 Category: Neurology Authors: Kizito-Tshitoko Tshilenge Joanna Bons Carlos Galicia Aguirre Cristian Geronimo-Olvera Samah Shah Jacob Rose Akos A Gerencser Sally K Mak Michelle E Ehrlich D Cristopher Bragg Birgit Schilling Lisa M Ellerby Source Type: research
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
Neurobiol Dis. 2023 Nov 30:106367. doi: 10.1016/j.nbd.2023.106367. Online ahead of print.ABSTRACTX-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within intron 32 of TATA-binding protein associated factor 1 (TAF1) that causes an alteration of TAF1 splicing, partial intron retention, and decreased transcription. Although TAF1 is expressed in all organs, medium spiny neurons (MSNs) within the striatum are one of the cell types most affected in XDP. To define how mutations in the TAF1 gen...
Source: Neurobiology of Disease - December 2, 2023 Category: Neurology Authors: Kizito-Tshitoko Tshilenge Joanna Bons Carlos Galicia Aguirre Cristian Geronimo-Olvera Samah Shah Jacob Rose Akos A Gerencser Sally K Mak Michelle E Ehrlich D Cristopher Bragg Birgit Schilling Lisa M Ellerby Source Type: research
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
Neurobiol Dis. 2023 Nov 29:106368. doi: 10.1016/j.nbd.2023.106368. Online ahead of print.ABSTRACTIn Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to reduce proteolytic cleavage and ameliorate the consequences of mutant HTT without lowering total HTT levels. To that end, we use an antisense oligonucleotide (AON) that targets HTT pre-mRNA and induces partial skipping of exon 12, which contains the critical caspase-6 cleavage site. Here, we show that AON-treatment can partially restore the phenoty...
Source: Neurobiology of Disease - December 1, 2023 Category: Neurology Authors: Elsa C Kuijper Maurice Overzier Ernst Suidgeest Oleh Dzyubachyk Cecile Maguin Jean-Baptiste P érot Julien Flament Yavuz Ariyurek Hailiang Mei Ronald A M Buijsen Louise van der Weerd Willeke van Roon-Mom Source Type: research
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
Neurobiol Dis. 2023 Nov 29:106368. doi: 10.1016/j.nbd.2023.106368. Online ahead of print.ABSTRACTIn Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to reduce proteolytic cleavage and ameliorate the consequences of mutant HTT without lowering total HTT levels. To that end, we use an antisense oligonucleotide (AON) that targets HTT pre-mRNA and induces partial skipping of exon 12, which contains the critical caspase-6 cleavage site. Here, we show that AON-treatment can partially restore the phenoty...
Source: Neurobiology of Disease - December 1, 2023 Category: Neurology Authors: Elsa C Kuijper Maurice Overzier Ernst Suidgeest Oleh Dzyubachyk Cecile Maguin Jean-Baptiste P érot Julien Flament Yavuz Ariyurek Hailiang Mei Ronald A M Buijsen Louise van der Weerd Willeke van Roon-Mom Source Type: research
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
Neurobiol Dis. 2023 Nov 24:106364. doi: 10.1016/j.nbd.2023.106364. Online ahead of print.ABSTRACTGangliogliomas (GGs) represent the most frequent glioneuronal tumor entity associated with chronic recurrent seizures; rare anaplastic GGs variants retain the glioneuronal character. So far, key mechanisms triggering chronic hyperexcitability in the peritumoral area are unresolved. Based on a recent mouse model for anaplastic GG (BRAFV600E, mTOR activation and Trp53KO) we here assessed the influence of GG-secreted factors on non-neoplastic cells in-vitro. We generated conditioned medium (CM) from primary GG cell cultures to dev...
Source: Neurobiology of Disease - November 26, 2023 Category: Neurology Authors: Philipp M üller Dirk Dietrich Susanne Schoch Julika Pitsch Albert J Becker Silvia Cases-Cunillera Source Type: research
