Impaired olfactory identification in dementia-free individuals is associated with the functional abnormality of the precuneus
CONCLUSIONS: In addition to the olfactory circuit, the precuneus is a critical structure in the odor identification process, whose abnormal function underlies the olfactory identification impairment of dementia-free individuals.PMID:38527709 | DOI:10.1016/j.nbd.2024.106483 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 25, 2024 Category: Neurology Authors: Bo Xie Simin Yang Yitong Hao Yining Sun Ludi Li Chunjie Guo Yu Yang Source Type: research
Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease
Neurobiol Dis. 2024 Mar 23:106481. doi: 10.1016/j.nbd.2024.106481. Online ahead of print.ABSTRACTMicroglia contribute to the outcomes of various pathological conditions including Parkinson's disease (PD). Microglia are heterogenous, with a variety of states recently identified in aging and neurodegenerative disease models. Here, we delved into the diversity of microglia in a preclinical PD model featuring the G2019S mutation in LRRK2, a known pathological mutation associated with PD. Specifically, we investigated the 'dark microglia' (DM) and the 'disease-associated microglia' (DAM) which present a selective enrichment of ...
Source: Neurobiology of Disease - March 25, 2024 Category: Neurology Authors: L Iovino J Vander Zwaag G Kaur M Khakpour V Giusti M Donadon A Chiavegato L Tenorio-Lopes E Greggio M E Tremblay L Civiero Source Type: research
Impaired olfactory identification in dementia-free individuals is associated with the functional abnormality of the precuneus
CONCLUSIONS: In addition to the olfactory circuit, the precuneus is a critical structure in the odor identification process, whose abnormal function underlies the olfactory identification impairment of dementia-free individuals.PMID:38527709 | DOI:10.1016/j.nbd.2024.106483 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 25, 2024 Category: Neurology Authors: Bo Xie Simin Yang Yitong Hao Yining Sun Ludi Li Chunjie Guo Yu Yang Source Type: research
Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease
Neurobiol Dis. 2024 Mar 23:106481. doi: 10.1016/j.nbd.2024.106481. Online ahead of print.ABSTRACTMicroglia contribute to the outcomes of various pathological conditions including Parkinson's disease (PD). Microglia are heterogenous, with a variety of states recently identified in aging and neurodegenerative disease models. Here, we delved into the diversity of microglia in a preclinical PD model featuring the G2019S mutation in LRRK2, a known pathological mutation associated with PD. Specifically, we investigated the 'dark microglia' (DM) and the 'disease-associated microglia' (DAM) which present a selective enrichment of ...
Source: Neurobiology of Disease - March 25, 2024 Category: Neurology Authors: L Iovino J Vander Zwaag G Kaur M Khakpour V Giusti M Donadon A Chiavegato L Tenorio-Lopes E Greggio M E Tremblay L Civiero Source Type: research
Impaired olfactory identification in dementia-free individuals is associated with the functional abnormality of the precuneus
CONCLUSIONS: In addition to the olfactory circuit, the precuneus is a critical structure in the odor identification process, whose abnormal function underlies the olfactory identification impairment of dementia-free individuals.PMID:38527709 | DOI:10.1016/j.nbd.2024.106483 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 25, 2024 Category: Neurology Authors: Bo Xie Simin Yang Yitong Hao Yining Sun Ludi Li Chunjie Guo Yu Yang Source Type: research
Parvalbumin neurons in the nucleus accumbens shell modulate seizure in temporal lobe epilepsy
In this study, we induced a spontaneous TLE model by intrahippocampal administration of kainic acid (KA), which generally induce acute seizures in first 2 h (acute phase) and then lead to spontaneous recurrent seizures after two months (chronic phase). We found that chemogenetic activation of NAc shell PV neurons could alleviate TLE seizures by reducing the number and period of focal seizures (FSs) and secondary generalized seizures (sGSs), while selective inhibition of PV exacerbated seizure activity. Ruby-virus mapping results identified that the hippocampus (ventral and dorsal) is one of the projection targets of NAc sh...
Source: Neurobiology of Disease - March 24, 2024 Category: Neurology Authors: Tong Jiang Shuyu Liang Xiaohan Zhang Shasha Dong HaiFang Zhu Ying Wang Yanping Sun Source Type: research
Parvalbumin neurons in the nucleus accumbens shell modulate seizure in temporal lobe epilepsy
In this study, we induced a spontaneous TLE model by intrahippocampal administration of kainic acid (KA), which generally induce acute seizures in first 2 h (acute phase) and then lead to spontaneous recurrent seizures after two months (chronic phase). We found that chemogenetic activation of NAc shell PV neurons could alleviate TLE seizures by reducing the number and period of focal seizures (FSs) and secondary generalized seizures (sGSs), while selective inhibition of PV exacerbated seizure activity. Ruby-virus mapping results identified that the hippocampus (ventral and dorsal) is one of the projection targets of NAc sh...
Source: Neurobiology of Disease - March 24, 2024 Category: Neurology Authors: Tong Jiang Shuyu Liang Xiaohan Zhang Shasha Dong HaiFang Zhu Ying Wang Yanping Sun Source Type: research
Deciphering the shift from benign to active relapsing-remitting multiple sclerosis: Insights into T regulatory cell dysfunction and apoptosis regulation
CONCLUSIONS: The intricate gene regulatory networks that operate in switching-BMS are related to suppression of immune tolerance and aberrant apoptosis. These findings may lead to new therapeutic targets to prevent the escalation to active disease.PMID:38521093 | DOI:10.1016/j.nbd.2024.106475 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 23, 2024 Category: Neurology Authors: Anat Achiron Rina Falb Shay Menascu David Magalashvili Mathilda Mandel Polina Sonis Michael Gurevich Source Type: research
Corrigendum to "Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy" [Neurobiology of Disease 136 (2020) 104715]
Neurobiol Dis. 2024 Mar 23:106480. doi: 10.1016/j.nbd.2024.106480. Online ahead of print.NO ABSTRACTPMID:38521728 | DOI:10.1016/j.nbd.2024.106480 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 23, 2024 Category: Neurology Authors: Li-Tao Yi Shu-Qi Dong Shuang-Shuang Wang Min Chen Cheng-Fu Li Di Geng Ji-Xiao Zhu Qing Liu Jie Cheng Source Type: research
Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
Neurobiol Dis. 2024 Mar 20:106474. doi: 10.1016/j.nbd.2024.106474. Online ahead of print.ABSTRACTA key pathological feature of Parkinson's Disease (PD) is the progressive degeneration of dopaminergic neurons (DAns) in the substantia nigra pars compacta. Considering the major role of EN1 in the development and maintenance of these DAns and the implications from En1 mouse models, it is highly interesting to study the molecular and protective effect of EN1 also in a human cellular model. Therefore, we generated EN1 knock-out (ko) human induced pluripotent stem cell (hiPSCs) lines and analyzed these during neuronal differentia...
Source: Neurobiology of Disease - March 22, 2024 Category: Neurology Authors: Sina Hembach Sebastian Schmidt Tanja Orschmann Ingo Burtscher Heiko Lickert Florian Giesert Daniela Vogt Weisenhorn Wolfgang Wurst Source Type: research
Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
Neurobiol Dis. 2024 Mar 20:106474. doi: 10.1016/j.nbd.2024.106474. Online ahead of print.ABSTRACTA key pathological feature of Parkinson's Disease (PD) is the progressive degeneration of dopaminergic neurons (DAns) in the substantia nigra pars compacta. Considering the major role of EN1 in the development and maintenance of these DAns and the implications from En1 mouse models, it is highly interesting to study the molecular and protective effect of EN1 also in a human cellular model. Therefore, we generated EN1 knock-out (ko) human induced pluripotent stem cell (hiPSCs) lines and analyzed these during neuronal differentia...
Source: Neurobiology of Disease - March 22, 2024 Category: Neurology Authors: Sina Hembach Sebastian Schmidt Tanja Orschmann Ingo Burtscher Heiko Lickert Florian Giesert Daniela Vogt Weisenhorn Wolfgang Wurst Source Type: research
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
In this study, we use biophysical modeling to shed light on such conditions. Our analysis reveals that the inherently nonlinear nature of the underlying molecular interactions can give rise to the emergence of various modes of hyperactivity. This diversity in the mechanisms of hyperactivity may ultimately account for a spectrum of AD manifestations.PMID:38493903 | DOI:10.1016/j.nbd.2024.106473 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 17, 2024 Category: Neurology Authors: Giulio Bonifazi Celia Luchena Adhara Gaminde-Blasco Carolina Ortiz-Sanz Estibaliz Capetillo-Zarate Carlos Matute Elena Alberdi Maurizio De Pitt à Source Type: research
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
In this study, we use biophysical modeling to shed light on such conditions. Our analysis reveals that the inherently nonlinear nature of the underlying molecular interactions can give rise to the emergence of various modes of hyperactivity. This diversity in the mechanisms of hyperactivity may ultimately account for a spectrum of AD manifestations.PMID:38493903 | DOI:10.1016/j.nbd.2024.106473 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 17, 2024 Category: Neurology Authors: Giulio Bonifazi Celia Luchena Adhara Gaminde-Blasco Carolina Ortiz-Sanz Estibaliz Capetillo-Zarate Carlos Matute Elena Alberdi Maurizio De Pitt à Source Type: research
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
In this study, we use biophysical modeling to shed light on such conditions. Our analysis reveals that the inherently nonlinear nature of the underlying molecular interactions can give rise to the emergence of various modes of hyperactivity. This diversity in the mechanisms of hyperactivity may ultimately account for a spectrum of AD manifestations.PMID:38493903 | DOI:10.1016/j.nbd.2024.106473 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 17, 2024 Category: Neurology Authors: Giulio Bonifazi Celia Luchena Adhara Gaminde-Blasco Carolina Ortiz-Sanz Estibaliz Capetillo-Zarate Carlos Matute Elena Alberdi Maurizio De Pitt à Source Type: research
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
In this study, we use biophysical modeling to shed light on such conditions. Our analysis reveals that the inherently nonlinear nature of the underlying molecular interactions can give rise to the emergence of various modes of hyperactivity. This diversity in the mechanisms of hyperactivity may ultimately account for a spectrum of AD manifestations.PMID:38493903 | DOI:10.1016/j.nbd.2024.106473 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 17, 2024 Category: Neurology Authors: Giulio Bonifazi Celia Luchena Adhara Gaminde-Blasco Carolina Ortiz-Sanz Estibaliz Capetillo-Zarate Carlos Matute Elena Alberdi Maurizio De Pitt à Source Type: research
