Identification of an epilepsy-linked gut microbiota signature in a pediatric rat model of acquired epilepsy
Neurobiol Dis. 2024 Mar 12:106469. doi: 10.1016/j.nbd.2024.106469. Online ahead of print.ABSTRACTA dysfunctional gut microbiota-brain axis is emerging as a potential pathogenic mechanism in epilepsy, particularly in pediatric forms of epilepsy. To add new insights into gut-related changes in acquired epilepsy that develops early in life, we used a multi-omics approach in a rat model with a 56% incidence of epilepsy. The presence of spontaneous seizures was assessed in adult rats (n = 46) 5 months after status epilepticus induced by intra-amygdala kainate at postnatal day 13, by 2 weeks (24/7) ECoG monitoring. Twenty-six ra...
Source: Neurobiology of Disease - March 14, 2024 Category: Neurology Authors: Antonella Riva Eray Sahin Greta Volpedo Andrea Petretto Chiara Lavarello Rossella Di Sapia Davide Barbarossa Nasibeh Riahi Zaniani Ilaria Craparotta Maria Chiara Barbera U ğur Sezerman Annamaria Vezzani Pasquale Striano Teresa Ravizza Source Type: research
Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Neurobiol Dis. 2024 Mar 12:106470. doi: 10.1016/j.nbd.2024.106470. Online ahead of print.ABSTRACTPathogenic variants in KCNB1 are associated with a neurodevelopmental disorder spectrum that includes global developmental delays, cognitive impairment, abnormal electroencephalogram (EEG) patterns, and epilepsy with variable age of onset and severity. Additionally, there are prominent behavioral disturbances, including hyperactivity, aggression, and features of autism spectrum disorder. The most frequently identified recurrent variant is KCNB1-p.R306C, a missense variant located within the S4 voltage-sensing transmembrane doma...
Source: Neurobiology of Disease - March 14, 2024 Category: Neurology Authors: Seok Kyu Kang Nicole A Hawkins Christopher H Thompson Erin M Baker Dennis M Echevarria-Cooper Levi Barse Tyler Thenstedt Conor J Dixon Nathan Speakes Alfred L George Jennifer A Kearney Source Type: research
Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseases
Neurobiol Dis. 2024 Mar 12:106463. doi: 10.1016/j.nbd.2024.106463. Online ahead of print.ABSTRACTMutations in NR2E3, a gene encoding an orphan nuclear transcription factor, cause two retinal dystrophies with a distinct phenotype, but the precise role of NR2E3 in rod and cone transcriptional networks remains unclear. To dissect NR2E3 function, we performed scRNA-seq in the retinas of wildtype and two different Nr2e3 mouse models that show phenotypes similar to patients carrying NR2E3 mutations. Our results reveal that rod and cone populations are not homogeneous and can be separated into different sub-classes. We identify a...
Source: Neurobiology of Disease - March 14, 2024 Category: Neurology Authors: Izarbe A ísa-Marín Quirze Rovira Noelia D íaz Laura Calvo-L ópez Juan M Vaquerizas Gemma Marfany Source Type: research
Identification of an epilepsy-linked gut microbiota signature in a pediatric rat model of acquired epilepsy
Neurobiol Dis. 2024 Mar 12:106469. doi: 10.1016/j.nbd.2024.106469. Online ahead of print.ABSTRACTA dysfunctional gut microbiota-brain axis is emerging as a potential pathogenic mechanism in epilepsy, particularly in pediatric forms of epilepsy. To add new insights into gut-related changes in acquired epilepsy that develops early in life, we used a multi-omics approach in a rat model with a 56% incidence of epilepsy. The presence of spontaneous seizures was assessed in adult rats (n = 46) 5 months after status epilepticus induced by intra-amygdala kainate at postnatal day 13, by 2 weeks (24/7) ECoG monitoring. Twenty-six ra...
Source: Neurobiology of Disease - March 14, 2024 Category: Neurology Authors: Antonella Riva Eray Sahin Greta Volpedo Andrea Petretto Chiara Lavarello Rossella Di Sapia Davide Barbarossa Nasibeh Riahi Zaniani Ilaria Craparotta Maria Chiara Barbera U ğur Sezerman Annamaria Vezzani Pasquale Striano Teresa Ravizza Source Type: research
Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Neurobiol Dis. 2024 Mar 12:106470. doi: 10.1016/j.nbd.2024.106470. Online ahead of print.ABSTRACTPathogenic variants in KCNB1 are associated with a neurodevelopmental disorder spectrum that includes global developmental delays, cognitive impairment, abnormal electroencephalogram (EEG) patterns, and epilepsy with variable age of onset and severity. Additionally, there are prominent behavioral disturbances, including hyperactivity, aggression, and features of autism spectrum disorder. The most frequently identified recurrent variant is KCNB1-p.R306C, a missense variant located within the S4 voltage-sensing transmembrane doma...
Source: Neurobiology of Disease - March 14, 2024 Category: Neurology Authors: Seok Kyu Kang Nicole A Hawkins Christopher H Thompson Erin M Baker Dennis M Echevarria-Cooper Levi Barse Tyler Thenstedt Conor J Dixon Nathan Speakes Alfred L George Jennifer A Kearney Source Type: research
Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseases
Neurobiol Dis. 2024 Mar 12:106463. doi: 10.1016/j.nbd.2024.106463. Online ahead of print.ABSTRACTMutations in NR2E3, a gene encoding an orphan nuclear transcription factor, cause two retinal dystrophies with a distinct phenotype, but the precise role of NR2E3 in rod and cone transcriptional networks remains unclear. To dissect NR2E3 function, we performed scRNA-seq in the retinas of wildtype and two different Nr2e3 mouse models that show phenotypes similar to patients carrying NR2E3 mutations. Our results reveal that rod and cone populations are not homogeneous and can be separated into different sub-classes. We identify a...
Source: Neurobiology of Disease - March 14, 2024 Category: Neurology Authors: Izarbe A ísa-Marín Quirze Rovira Noelia D íaz Laura Calvo-L ópez Juan M Vaquerizas Gemma Marfany Source Type: research
Microstructural alterations of the hypothalamus in Parkinson's disease and probable REM sleep behavior disorder
CONCLUSIONS: Our study reveals that microstructural changes in the hypothalamus are already significant at the early neurodegenerative stage. These changes are associated with emotional alterations, daily activity levels, and thyroid hormone levels.PMID:38479482 | DOI:10.1016/j.nbd.2024.106472 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - March 13, 2024 Category: Neurology Authors: Cheng Zhou Jia You Xiaojun Guan Tao Guo Jingjing Wu Haoting Wu Chenqing Wu Jingwen Chen Jiaqi Wen Sijia Tan Xioajie Duanmu Jianmei Qin Peiyu Huang Baorong Zhang Wei Cheng Jianfeng Feng Xiaojun Xu Linbo Wang Minming Zhang Source Type: research
Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity
Neurobiol Dis. 2024 Mar 10:106466. doi: 10.1016/j.nbd.2024.106466. Online ahead of print.ABSTRACTIn recent studies, brain stimulation has shown promising potential to alleviate chronic pain. Although studies have shown that stimulation of pain-related brain regions can induce pain-relieving effects, few studies have elucidated the mechanisms of brain stimulation in the insular cortex (IC). The present study was conducted to explore the changes in characteristic molecules involved in pain modulation mechanisms and to identify the changes in synaptic plasticity after IC stimulation (ICS). Following ICS, pain-relieving behavi...
Source: Neurobiology of Disease - March 12, 2024 Category: Neurology Authors: Kyeongmin Kim Guanghai Nan Hyeji Bak Hee Young Kim Junesun Kim Myeounghoon Cha Bae Hwan Lee Source Type: research
Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity
Neurobiol Dis. 2024 Mar 10:106466. doi: 10.1016/j.nbd.2024.106466. Online ahead of print.ABSTRACTIn recent studies, brain stimulation has shown promising potential to alleviate chronic pain. Although studies have shown that stimulation of pain-related brain regions can induce pain-relieving effects, few studies have elucidated the mechanisms of brain stimulation in the insular cortex (IC). The present study was conducted to explore the changes in characteristic molecules involved in pain modulation mechanisms and to identify the changes in synaptic plasticity after IC stimulation (ICS). Following ICS, pain-relieving behavi...
Source: Neurobiology of Disease - March 12, 2024 Category: Neurology Authors: Kyeongmin Kim Guanghai Nan Hyeji Bak Hee Young Kim Junesun Kim Myeounghoon Cha Bae Hwan Lee Source Type: research
Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain
Neurobiol Dis. 2024 Mar 8:106471. doi: 10.1016/j.nbd.2024.106471. Online ahead of print.ABSTRACTEmerging evidence has implicated an important role of synapse-associated protein-97 (SAP97)-regulated GluA1-containing AMPARs membrane trafficking in cocaine restate and in contextual episodic memory of schizophrenia. Herein, we investigated the role of SAP97 in neuropathic pain following lumbar 5 spinal nerve transection (SNT) in rats. Our results showed that SNT led to upregulation of SAP97, enhanced the interaction between SAP97 and GluA1, and increased GluA1-containing AMPARs membrane trafficking in the dorsal horn. Microinj...
Source: Neurobiology of Disease - March 10, 2024 Category: Neurology Authors: Zongyi Liang Liren Li Liying Bai Yan Gao Yiming Qiao Xueli Wang Lili Yv Ji-Tian Xu Source Type: research
Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain
Neurobiol Dis. 2024 Mar 8:106471. doi: 10.1016/j.nbd.2024.106471. Online ahead of print.ABSTRACTEmerging evidence has implicated an important role of synapse-associated protein-97 (SAP97)-regulated GluA1-containing AMPARs membrane trafficking in cocaine restate and in contextual episodic memory of schizophrenia. Herein, we investigated the role of SAP97 in neuropathic pain following lumbar 5 spinal nerve transection (SNT) in rats. Our results showed that SNT led to upregulation of SAP97, enhanced the interaction between SAP97 and GluA1, and increased GluA1-containing AMPARs membrane trafficking in the dorsal horn. Microinj...
Source: Neurobiology of Disease - March 10, 2024 Category: Neurology Authors: Zongyi Liang Liren Li Liying Bai Yan Gao Yiming Qiao Xueli Wang Lili Yv Ji-Tian Xu Source Type: research
Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice
Neurobiol Dis. 2024 Mar 7:106465. doi: 10.1016/j.nbd.2024.106465. Online ahead of print.ABSTRACTChildren who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which...
Source: Neurobiology of Disease - March 9, 2024 Category: Neurology Authors: Karen K Y Lee Bidisha Chattopadhyaya Ant ônia Samia Fernandes do Nascimento Luc Moquin Pedro Rosa-Neto B énédicte Amilhon Graziella Di Cristo Source Type: research
Cathepsin B as a key regulator of ferroptosis in microglia following intracerebral hemorrhage
Neurobiol Dis. 2024 Mar 7:106468. doi: 10.1016/j.nbd.2024.106468. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a subtype of stroke marked by elevated mortality and disability rates. Recently, mounting evidence suggests a significant role of ferroptosis in the pathogenesis of ICH. Through a combination of bioinformatics analysis and basic experiments, our goal is to identify the primary cell types and key molecules implicated in ferroptosis post-ICH. This aims to propel the advancement of ferroptosis research, offering potential therapeutic targets for ICH treatment. Our study reveals pronounced ferroptos...
Source: Neurobiology of Disease - March 9, 2024 Category: Neurology Authors: Jinxin Lu Haiying Li Zhengquan Yu Chang Cao Zhongmou Xu Lu Peng John H Zhang Gang Chen Source Type: research
Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice
Neurobiol Dis. 2024 Mar 7:106465. doi: 10.1016/j.nbd.2024.106465. Online ahead of print.ABSTRACTChildren who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which...
Source: Neurobiology of Disease - March 9, 2024 Category: Neurology Authors: Karen K Y Lee Bidisha Chattopadhyaya Ant ônia Samia Fernandes do Nascimento Luc Moquin Pedro Rosa-Neto B énédicte Amilhon Graziella Di Cristo Source Type: research
Cathepsin B as a key regulator of ferroptosis in microglia following intracerebral hemorrhage
Neurobiol Dis. 2024 Mar 7:106468. doi: 10.1016/j.nbd.2024.106468. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a subtype of stroke marked by elevated mortality and disability rates. Recently, mounting evidence suggests a significant role of ferroptosis in the pathogenesis of ICH. Through a combination of bioinformatics analysis and basic experiments, our goal is to identify the primary cell types and key molecules implicated in ferroptosis post-ICH. This aims to propel the advancement of ferroptosis research, offering potential therapeutic targets for ICH treatment. Our study reveals pronounced ferroptos...
Source: Neurobiology of Disease - March 9, 2024 Category: Neurology Authors: Jinxin Lu Haiying Li Zhengquan Yu Chang Cao Zhongmou Xu Lu Peng John H Zhang Gang Chen Source Type: research
