Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP
Neurobiol Dis. 2023 Nov 15;189:106356. doi: 10.1016/j.nbd.2023.106356. Online ahead of print.ABSTRACTCSF-to-plasma transition will open new avenues for molecular phenotyping of Alzheimer's disease (AD). Here we evaluated a panel of AD biomarkers in matched CSF and plasma samples across the AD continuum, from preclinical AD to dementia. The aims were to: 1) compare diagnostic performance of the two biofluids, 2) evaluate trajectories of the biomarkers along AD progression. We analyzed CSF and plasma Aβ42/40, p-tau181, p-tau231, t-tau, NF-L, GFAP, UCHL-1 and CSF SNAP-25 in a cohort (n = 173) of preclinical AD, MCI-AD, AD de...
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Anna Lidia Wojda ła Giovanni Bellomo Lorenzo Gaetani Andrea Toja Elena Chipi Dandan Shan Davide Chiasserini Lucilla Parnetti Source Type: research
Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years
CONCLUSION: We found that genetic predisposition of AD predicted cognitive decline among 70-year-olds followed over 16 years, regardless of dementia status, while polygenic risk for general cognitive performance did not.PMID:37977433 | DOI:10.1016/j.nbd.2023.106357 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Jenna Najar Valgeir Thorvaldsson Silke Kern Johan Skoog Margda Waern Henrik Zetterberg Kaj Blennow Ingmar Skoog Anna Zettergren Source Type: research
Projection-defined median raphe Pet < sup > + < /sup > subpopulations are diversely implicated in seizure
Neurobiol Dis. 2023 Nov 15;189:106358. doi: 10.1016/j.nbd.2023.106358. Online ahead of print.ABSTRACTThe raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortical excitabilities. Fundamental circuit organizations of different median raphe (MR) subsystems are far from completely understood. In the present study, using cell-specific viral tracing, Ca2+ fiber photometry and epilepsy model, we map out the forebrain efferent and afferent of different MR Pet+ subpopulations and their divergent roles in epilepsy. We found that PetMR neurons send both collateral and pa...
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Heming Cheng Qiuwen Lou Nanxi Lai Liying Chen Shuo Zhang Fan Fei Chenshu Gao Shuangshuang Wu Feng Han Jinggen Liu Yi Guo Zhong Chen Cenglin Xu Yi Wang Source Type: research
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus
In conclusion, this study showed consistent but heterogeneous modulation of LC neurons and a consistent time-locked release of hippocampal noradrenaline during acute hippocampal seizures.PMID:37977430 | DOI:10.1016/j.nbd.2023.106355 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Lars Emil Larsen Sielke Caestecker Latoya Stevens Pieter van Mierlo Evelien Carrette Paul Boon Kristl Vonck Robrecht Raedt Source Type: research
Gray matter structural covariance networks patterns associated with autopsy-confirmed LATE-NC compared to Alzheimer's disease pathology
CONCLUSIONS: This study showed different SCN patterns in the cases with LATE-NC, AD, and AD+LATE-NC, and indicated the network disconnection mechanism underlying these three neuropathological progressions. Further, SCN may serve as an effective biomarker to distinguish between different types of dementia.PMID:37977431 | DOI:10.1016/j.nbd.2023.106354 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Kaicheng Li Xiao Luo Qingze Zeng Xiaocao Liu Jixuan Li Siyan Zhong Xinyi Zhang Xiaopei Xu Shuyue Wang Hui Hong Yerfan Jiaerken Zhirong Liu Shuai Zhao Peiyu Huang Minming Zhang Yanxing Chen Alzheimer's Disease Neuroimaging Initiative Source Type: research
Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: Disease staging by NF-L, p-tau181, and GFAP
Neurobiol Dis. 2023 Nov 15:106356. doi: 10.1016/j.nbd.2023.106356. Online ahead of print.ABSTRACTCSF-to-plasma transition will open new avenues for molecular phenotyping of Alzheimer's disease (AD). Here we evaluated a panel of AD biomarkers in matched CSF and plasma samples across the AD continuum, from preclinical AD to dementia. The aims were to: 1) compare diagnostic performance of the two biofluids, 2) evaluate trajectories of the biomarkers along AD progression. We analyzed CSF and plasma Aβ42/40, p-tau181, p-tau231, t-tau, NF-L, GFAP, UCHL-1 and CSF SNAP-25 in a cohort (n = 173) of preclinical AD, MCI-AD, AD dement...
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Anna Lidia Wojda ła Giovanni Bellomo Lorenzo Gaetani Andrea Toja Elena Chipi Dandan Shan Davide Chiasserini Lucilla Parnetti Source Type: research
Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years
CONCLUSION: We found that genetic predisposition of AD predicted cognitive decline among 70-year-olds followed over 16 years, regardless of dementia status, while polygenic risk for general cognitive performance did not.PMID:37977433 | DOI:10.1016/j.nbd.2023.106357 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Jenna Najar Valgeir Thorvaldsson Silke Kern Johan Skoog Margda Waern Henrik Zetterberg Kaj Blennow Ingmar Skoog Anna Zettergren Source Type: research
Projection-defined median raphe Pet < sup > + < /sup > subpopulations are diversely implicated in seizure
Neurobiol Dis. 2023 Nov 15;189:106358. doi: 10.1016/j.nbd.2023.106358. Online ahead of print.ABSTRACTThe raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortical excitabilities. Fundamental circuit organizations of different median raphe (MR) subsystems are far from completely understood. In the present study, using cell-specific viral tracing, Ca2+ fiber photometry and epilepsy model, we map out the forebrain efferent and afferent of different MR Pet+ subpopulations and their divergent roles in epilepsy. We found that PetMR neurons send both collateral and pa...
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Heming Cheng Qiuwen Lou Nanxi Lai Liying Chen Shuo Zhang Fan Fei Chenshu Gao Shuangshuang Wu Feng Han Jinggen Liu Yi Guo Zhong Chen Cenglin Xu Yi Wang Source Type: research
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus
In conclusion, this study showed consistent but heterogeneous modulation of LC neurons and a consistent time-locked release of hippocampal noradrenaline during acute hippocampal seizures.PMID:37977430 | DOI:10.1016/j.nbd.2023.106355 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Lars Emil Larsen Sielke Caestecker Latoya Stevens Pieter van Mierlo Evelien Carrette Paul Boon Kristl Vonck Robrecht Raedt Source Type: research
Gray matter structural covariance networks patterns associated with autopsy-confirmed LATE-NC compared to Alzheimer's disease pathology
CONCLUSIONS: This study showed different SCN patterns in the cases with LATE-NC, AD, and AD+LATE-NC, and indicated the network disconnection mechanism underlying these three neuropathological progressions. Further, SCN may serve as an effective biomarker to distinguish between different types of dementia.PMID:37977431 | DOI:10.1016/j.nbd.2023.106354 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Kaicheng Li Xiao Luo Qingze Zeng Xiaocao Liu Jixuan Li Siyan Zhong Xinyi Zhang Xiaopei Xu Shuyue Wang Hui Hong Yerfan Jiaerken Zhirong Liu Shuai Zhao Peiyu Huang Minming Zhang Yanxing Chen Alzheimer's Disease Neuroimaging Initiative Source Type: research
Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: Disease staging by NF-L, p-tau181, and GFAP
Neurobiol Dis. 2023 Nov 15:106356. doi: 10.1016/j.nbd.2023.106356. Online ahead of print.ABSTRACTCSF-to-plasma transition will open new avenues for molecular phenotyping of Alzheimer's disease (AD). Here we evaluated a panel of AD biomarkers in matched CSF and plasma samples across the AD continuum, from preclinical AD to dementia. The aims were to: 1) compare diagnostic performance of the two biofluids, 2) evaluate trajectories of the biomarkers along AD progression. We analyzed CSF and plasma Aβ42/40, p-tau181, p-tau231, t-tau, NF-L, GFAP, UCHL-1 and CSF SNAP-25 in a cohort (n = 173) of preclinical AD, MCI-AD, AD dement...
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Anna Lidia Wojda ła Giovanni Bellomo Lorenzo Gaetani Andrea Toja Elena Chipi Dandan Shan Davide Chiasserini Lucilla Parnetti Source Type: research
Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years
CONCLUSION: We found that genetic predisposition of AD predicted cognitive decline among 70-year-olds followed over 16 years, regardless of dementia status, while polygenic risk for general cognitive performance did not.PMID:37977433 | DOI:10.1016/j.nbd.2023.106357 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Jenna Najar Valgeir Thorvaldsson Silke Kern Johan Skoog Margda Waern Henrik Zetterberg Kaj Blennow Ingmar Skoog Anna Zettergren Source Type: research
Projection-defined median raphe Pet < sup > + < /sup > subpopulations are diversely implicated in seizure
Neurobiol Dis. 2023 Nov 15:106358. doi: 10.1016/j.nbd.2023.106358. Online ahead of print.ABSTRACTThe raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortical excitabilities. Fundamental circuit organizations of different median raphe (MR) subsystems are far from completely understood. In the present study, using cell-specific viral tracing, Ca2+ fiber photometry and epilepsy model, we map out the forebrain efferent and afferent of different MR Pet+ subpopulations and their divergent roles in epilepsy. We found that PetMR neurons send both collateral and parall...
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Heming Cheng Qiuwen Lou Nanxi Lai Liying Chen Shuo Zhang Fan Fei Chenshu Gao Shuangshuang Wu Feng Han Jinggen Liu Yi Guo Zhong Chen Cenglin Xu Yi Wang Source Type: research
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus
In conclusion, this study showed consistent but heterogeneous modulation of LC neurons and a consistent time-locked release of hippocampal noradrenaline during acute hippocampal seizures.PMID:37977430 | DOI:10.1016/j.nbd.2023.106355 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Lars Emil Larsen Sielke Caestecker Latoya Stevens Pieter van Mierlo Evelien Carrette Paul Boon Kristl Vonck Robrecht Raedt Source Type: research
Gray matter structural covariance networks patterns associated with autopsy-confirmed LATE-NC compared to Alzheimer's disease pathology
CONCLUSIONS: This study showed different SCN patterns in the cases with LATE-NC, AD, and AD+LATE-NC, and indicated the network disconnection mechanism underlying these three neuropathological progressions. Further, SCN may serve as an effective biomarker to distinguish between different types of dementia.PMID:37977431 | DOI:10.1016/j.nbd.2023.106354 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 17, 2023 Category: Neurology Authors: Kaicheng Li Xiao Luo Qingze Zeng Xiaocao Liu Jixuan Li Siyan Zhong Xinyi Zhang Xiaopei Xu Shuyue Wang Hui Hong Yerfan Jiaerken Zhirong Liu Shuai Zhao Peiyu Huang Minming Zhang Yanxing Chen Alzheimer's Disease Neuroimaging Initiative Source Type: research
