T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease
Neurobiol Dis. 2024 Mar 2:106461. doi: 10.1016/j.nbd.2024.106461. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of β-amyloid (Aβ) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. So far, our understanding of the extent and role of adaptive immune responses in AD has been quite limited. T cells, as essential members of the adaptive immune system, exhibit quantitative and functional abnormalities in the brains of AD patients. Dysfunction of the blood-brain barrier (BBB) in AD is considered one...
Source: Neurobiology of Disease - March 4, 2024 Category: Neurology Authors: Junjian Zeng Zhiqiang Liao Hanqin Yang Qiong Wang Zhiyong Wu Fuzhou Hua Zhidong Zhou Source Type: research
Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: Insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa
In this study, we investigate the role of the gut microbiome in appetite regulation using activity-based anorexia (ABA) mouse model of anorexia nervosa (AN) - a severe eating disorder with significant health consequences. ABA was induced in conventional, antibiotic-treated, and germ-free mice. Our results show the clear influence of the gut microbiome on the expression of four orexigenic (neuropeptide Y, agouti-related peptide, melanin-concentrating hormone, and orexin) and four anorexigenic peptides (cocaine- and amphetamine-regulated transcript, corticotropin-releasing hormone, thyrotropin-releasing hormone, and pro-opio...
Source: Neurobiology of Disease - March 3, 2024 Category: Neurology Authors: Radka Roubalov á Petra Proch ázková Tereza Kov ářová Janet Je žková Tom áš Hrnčíř Helena Tlaskalov á-Hogenová Hana Pape žová Source Type: research
Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice
In this study, a GAD-Cre;Clockflox/flox mouse line with conditional Clock gene knockout in inhibitory neurons was established. We observed that seizure latency was prolonged, the severity and mortality of pilocarpine-induced seizure were significantly reduced, and memory was improved in GAD-Cre;Clockflox/flox mice. We hypothesize that mice with CLOCK knockout in inhibitory neurons have increased threshold for seizure, opposite from mice with CLOCK knockout in excitatory neurons. Further investigation showed Clock knockout in inhibitory neurons upregulated the basal protein level of ARC, a synaptic plasticity-associated imm...
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Lu Deng Hong Jiang Jingjing Lin Di Xu Ailin Qi Qing Guo Ping-Ping Li Xinshi Wang Judy S Liu Xiaoqin Fu Peijun Li Source Type: research
The free plasma amyloid A β < sub > 1 < /sub > < sub > - < /sub > < sub > 42 < /sub > /A β < sub > 1 < /sub > < sub > - < /sub > < sub > 40 < /sub > ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma A β < sub > 1 < /sub > < sub > - < /sub > < sub > 42 < /sub > /A β < sub > 1 < /sub > < sub > - < /sub > < sub > 40 < /sub > ratio. The BALTAZAR study
CONCLUSION: The free plasma Aβ1-42/Aβ1-40 ratio is associated with a risk of conversion from MCI to dementia within three years, with performance comparable to that of the total plasma Aβ1-42/Aβ1-40 ratio. Threshold levels of the free and total plasma Aβ1-42/Aβ1-40 ratio could be determined, with a 60% lower risk of conversion for patients above the threshold than those below.PMID:38423192 | DOI:10.1016/j.nbd.2024.106459 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: S Schraen-Maschke A Duhamel J S Vidal N Ramdane L Vaudran C Dussart L Bu ée B Sablonni ère C Delaby B Allinquant A Gabelle S Bombois S Lehmann O Hanon BALTAZAR study group Source Type: research
Blood and cerebellar abundance of ATXN3 splice variants in spinocerebellar ataxia type 3/Machado-Joseph disease
Neurobiol Dis. 2024 Feb 27:106456. doi: 10.1016/j.nbd.2024.106456. Online ahead of print.ABSTRACTSpinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) is a heritable proteinopathy disorder, whose causative gene, ATXN3, undergoes alternative splicing. Ataxin-3 protein isoforms differ in their toxicity, suggesting that certain ATXN3 splice variants may be crucial in driving the selective toxicity in SCA3. Using RNA-seq datasets we identified and determined the abundance of annotated ATXN3 transcripts in blood (n = 60) and cerebellum (n = 12) of SCA3 subjects and controls. The reference transcript (ATXN3-251), tra...
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Mafalda Raposo Jeannette H übener-Schmid Rebecca Tagett Ana F Ferreira Ana Rosa Vieira Melo Jo ão Vasconcelos Paula Pires Teresa Kay Hector Garcia-Moreno Paola Giunti Magda M Santana Luis Pereira de Almeida Jon Infante Bart P van de Warrenburg Jeroen J Source Type: research
Alteration of gut microbiota in post-stroke depression patients with Helicobacter pylori infection
CONCLUSION: DWMLs and H. pylori infection may play important roles in the development of PSD. H. pylori infection is likely to be involved in the pathogenesis of PSD by altering the intestinal flora.PMID:38423194 | DOI:10.1016/j.nbd.2024.106458 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Mei Sun Han Chen Siyu Dong Guoxin Zhang Xiaoying Zhou Hong Cheng Source Type: research
Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice
In this study, a GAD-Cre;Clockflox/flox mouse line with conditional Clock gene knockout in inhibitory neurons was established. We observed that seizure latency was prolonged, the severity and mortality of pilocarpine-induced seizure were significantly reduced, and memory was improved in GAD-Cre;Clockflox/flox mice. We hypothesize that mice with CLOCK knockout in inhibitory neurons have increased threshold for seizure, opposite from mice with CLOCK knockout in excitatory neurons. Further investigation showed Clock knockout in inhibitory neurons upregulated the basal protein level of ARC, a synaptic plasticity-associated imm...
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Lu Deng Hong Jiang Jingjing Lin Di Xu Ailin Qi Qing Guo Ping-Ping Li Xinshi Wang Judy S Liu Xiaoqin Fu Peijun Li Source Type: research
The free plasma amyloid A β < sub > 1-42 < /sub > /A β < sub > 1-40 < /sub > ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma A β < sub > 1-42 < /sub > /A β < sub > 1-40 < /sub > ratio. The BALTAZAR study
CONCLUSION: The free plasma Aβ1-42/Aβ1-40 ratio is associated with a risk of conversion from MCI to dementia within three years, with performance comparable to that of the total plasma Aβ1-42/Aβ1-40 ratio. Threshold levels of the free and total plasma Aβ1-42/Aβ1-40 ratio could be determined, with a 60% lower risk of conversion for patients above the threshold than those below.PMID:38423192 | DOI:10.1016/j.nbd.2024.106459 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: S Schraen-Maschke A Duhamel J S Vidal N Ramdane L Vaudran C Dussart L Bu ée B Sablonni ère C Delaby B Allinquant A Gabelle S Bombois S Lehmann O Hanon BALTAZAR study group Source Type: research
Blood and cerebellar abundance of ATXN3 splice variants in spinocerebellar ataxia type 3/Machado-Joseph disease
Neurobiol Dis. 2024 Feb 27:106456. doi: 10.1016/j.nbd.2024.106456. Online ahead of print.ABSTRACTSpinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) is a heritable proteinopathy disorder, whose causative gene, ATXN3, undergoes alternative splicing. Ataxin-3 protein isoforms differ in their toxicity, suggesting that certain ATXN3 splice variants may be crucial in driving the selective toxicity in SCA3. Using RNA-seq datasets we identified and determined the abundance of annotated ATXN3 transcripts in blood (n = 60) and cerebellum (n = 12) of SCA3 subjects and controls. The reference transcript (ATXN3-251), tra...
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Mafalda Raposo Jeannette H übener-Schmid Rebecca Tagett Ana F Ferreira Ana Rosa Vieira Melo Jo ão Vasconcelos Paula Pires Teresa Kay Hector Garcia-Moreno Paola Giunti Magda M Santana Luis Pereira de Almeida Jon Infante Bart P van de Warrenburg Jeroen J Source Type: research
Alteration of gut microbiota in post-stroke depression patients with Helicobacter pylori infection
CONCLUSION: DWMLs and H. pylori infection may play important roles in the development of PSD. H. pylori infection is likely to be involved in the pathogenesis of PSD by altering the intestinal flora.PMID:38423194 | DOI:10.1016/j.nbd.2024.106458 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Mei Sun Han Chen Siyu Dong Guoxin Zhang Xiaoying Zhou Hong Cheng Source Type: research
Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice
In this study, a GAD-Cre;Clockflox/flox mouse line with conditional Clock gene knockout in inhibitory neurons was established. We observed that seizure latency was prolonged, the severity and mortality of pilocarpine-induced seizure were significantly reduced, and memory was improved in GAD-Cre;Clockflox/flox mice. We hypothesize that mice with CLOCK knockout in inhibitory neurons have increased threshold for seizure, opposite from mice with CLOCK knockout in excitatory neurons. Further investigation showed Clock knockout in inhibitory neurons upregulated the basal protein level of ARC, a synaptic plasticity-associated imm...
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Lu Deng Hong Jiang Jingjing Lin Di Xu Ailin Qi Qing Guo Pingping Li Xinshi Wang Judy S Liu Xiaoqin Fu Peijun Li Source Type: research
The free plasma amyloid A β < sub > 1-42 < /sub > /A β < sub > 1-40 < /sub > ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma A β < sub > 1-42 < /sub > /A β < sub > 1-40 < /sub > ratio. The BALTAZAR study
CONCLUSION: The free plasma Aβ1-42/Aβ1-40 ratio is associated with a risk of conversion from MCI to dementia within three years, with performance comparable to that of the total plasma Aβ1-42/Aβ1-40 ratio. Threshold levels of the free and total plasma Aβ1-42/Aβ1-40 ratio could be determined, with a 60% lower risk of conversion for patients above the threshold than those below.PMID:38423192 | DOI:10.1016/j.nbd.2024.106459 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: S Schraen-Maschke A Duhamel J S Vidal N Ramdane L Vaudran C Dussart L Bu ée B Sablonni ère C Delaby B Allinquant A Gabelle S Bombois S Lehmann O Hanon BALTAZAR study group Source Type: research
Blood and cerebellar abundance of ATXN3 splice variants in spinocerebellar ataxia type 3/Machado-Joseph disease
Neurobiol Dis. 2024 Feb 27:106456. doi: 10.1016/j.nbd.2024.106456. Online ahead of print.ABSTRACTSpinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) is a heritable proteinopathy disorder, whose causative gene, ATXN3, undergoes alternative splicing. Ataxin-3 protein isoforms differ in their toxicity, suggesting that certain ATXN3 splice variants may be crucial in driving the selective toxicity in SCA3. Using RNA-seq datasets we identified and determined the abundance of annotated ATXN3 transcripts in blood (n = 60) and cerebellum (n = 12) of SCA3 subjects and controls. The reference transcript (ATXN3-251), tra...
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Mafalda Raposo Jeannette H übener-Schmid Rebecca Tagett Ana F Ferreira Ana Rosa Vieira Melo Jo ão Vasconcelos Paula Pires Teresa Kay Hector Garcia-Moreno Paola Giunti Magda M Santana Luis Pereira de Almeida Jon Infante Bart P van de Warrenburg Jeroen J Source Type: research
Alteration of gut microbiota in post-stroke depression patients with Helicobacter pylori infection
CONCLUSION: DWMLs and H. pylori infection may play important roles in the development of PSD. H. pylori infection is likely to be involved in the pathogenesis of PSD by altering the intestinal flora.PMID:38423194 | DOI:10.1016/j.nbd.2024.106458 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: Mei Sun Han Chen Siyu Dong Guoxin Zhang Xiaoying Zhou Hong Cheng Source Type: research
hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons
Neurobiol Dis. 2024 Feb 24:106454. doi: 10.1016/j.nbd.2024.106454. Online ahead of print.ABSTRACTAxonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis. The RNA-binding protein hnRNP R interacts with different motoneuron disease-related proteins such as SMN and TDP-43 and has important roles in axons of motoneurons, including axonal mRNA transport. However, whether hnRNP R also modulates axonal mitochondria is currently unknown. Here, we show that axonal mitochondria exhibit altered function and motility in hnRNP R-deficient...
Source: Neurobiology of Disease - February 26, 2024 Category: Neurology Authors: Sophia Dithmar Abdolhossein Zare Saeede Salehi Michael Briese Michael Sendtner Source Type: research
