Journal of Clinical Gastroenterology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Impact of COVID-19 in Gastroenterology and Hepatology
The 2019 coronavirus disease (COVID-19), an airborne infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic. SARS-CoV-2 relies on the angiotensin-converting enzyme 2 receptor for cellular entry and the abundance of this receptor in the gastrointestinal (GI) tract may help explain the GI manifestations, including dysgeusia, nausea, vomiting, diarrhea, and abdominal pain, present in over 40% of infected patients. GI tract involvement also raises the concern for oral-fecal transmission which is poorly understood. Outcome studies in COVID-19 patients with preexisting...
Source: Journal of Clinical Gastroenterology - September 3, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Management of Cardiometabolic Complications in Patients With Nonalcoholic Fatty Liver Disease: A Review of the Literature With Recommendations
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of liver conditions characterized by significant lipid deposition within hepatocytes. As an overarching diagnosis, NAFLD contains a continuum of progressive liver diseases ranging from isolated liver steatosis to necroinflammatory states leading to end-stage liver disease. Nonalcoholic fatty liver and nonalcoholic steatohepatitis are distinguished by their histologic patterns, with the former exhibiting steatosis without fibrosis or inflammation. This important distinction provides clinicians a timeline within the NAFLD staging to target appropriate intervention...
Source: Journal of Clinical Gastroenterology - September 3, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

First or Second Biologic in Inflammatory Bowel Disease: Combination Therapy or Monotherapy?
The therapeutic armamentarium for patients with inflammatory bowel disease has been expanding. Current guidelines make recommendations about whether patients who are biologic naive should be receiving biologic monotherapy or combination therapy, depending on the class of biologics. However, due to the limited available data, guidance to inform clinical practice for patients receiving their second or more biologic are lacking. We hereby review the available data about the use of biologic monotherapy or combination therapy with concomitant immunomodulator therapies in patients receiving their first as well as those receiving...
Source: Journal of Clinical Gastroenterology - September 3, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

A Polyp Worth Removing: A Paradigm for Measuring Colonoscopy Quality and Performance of Novel Technologies for Polyp Detection
Leaving no significant polyp behind while avoiding risks due to unnecessary resections is a commonsense strategy to safely and effectively prevent colorectal cancer (CRC) with colonoscopy. It also alludes to polyps worth removing and, therefore, worth finding. The majority of “worthy” precancerous polyps are adenomas, which for over 2 decades, have received the most attention in performance research and metrics. Consequently, the detection rate of adenomas is currently the only validated, outcome-based measure of colonoscopy demonstrated to correlate with reduced risk of postcolonoscopy CRC. However, a third or more of...
Source: Journal of Clinical Gastroenterology - September 3, 2021 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Differential Effectiveness of Tenofovir and Entecavir for Prophylaxis of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Depending on Coexisting Cirrhosis and Prior Exposure to Antiviral Therapy: A Systematic Review and Meta-analysis
Conclusions: TDF likely confers a lower risk of HCC development and longer survival in patients with CHB, especially among treatment-naive patients and those with underlying cirrhosis, than ETV. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - September 3, 2021 Category: Gastroenterology Tags: Online Article: Original Article Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - September 3, 2021 Category: Gastroenterology Tags: WGO News Source Type: research

Magnetically Controlled Capsule Gastroscopy, Automation, and Evidence Reviews
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Statins and Cancer Mortality in NAFLD: Is it Too Early to Rejoice?
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Comments on the “WGO Guidance for the Care of Patients With COVID-19 and Liver Disease”
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Outcomes of a Structured, Stepwise Approach to Endoscopic Necrosectomy
Conclusions: By decreasing the number of necrosectomy sessions, a structured, stepwise approach to endoscopic necrosectomy seems to improve procedural efficiency. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

The Effect of Hospital Safety-Net Burden and Patient Ethnicity on In-Hospital Mortality Among Hospitalized Patients With Cirrhosis
Background: Over 2.1 million individuals in the United Stats have cirrhosis, including 513,000 with decompensated cirrhosis. Hospitals with high safety-net burden disproportionately serve ethnic minorities and have reported worse outcomes in surgical literature. No studies to date have evaluated whether hospital safety-net burden negatively affects hospitalization outcomes in cirrhosis. We aim to evaluate the impact of hospitals’ safety-net burden and patients’ ethnicity on in-hospital mortality among cirrhosis patients. Methods: Using National Inpatient Sample data from 2012 to 2016, the largest United Stat...
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Efficacy and Safety of Statin for Hepatocellular Carcinoma Prevention Among Chronic Liver Disease Patients: A Systematic Review and Meta-analysis
Conclusion: Statin use was safe and associated with a lower pooled risk of HCC development among adults with CLD. Given the bias with observation studies, prospective randomised trial is needed to confirm this finding. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

Mental Health Factors Associated With Fatigue in Mexican Patients With Inflammatory Bowel Disease
Conclusions: Sleep quality and depression have an impact on fatigue in Mexican patients with IBD. It is important for multidisciplinary management to reduce these symptoms and improve the quality of life of patients with IBD. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Dose Augmentation of Tumor Necrosis Factor Inhibitors is Frequently Performed in Persons With Inflammatory Bowel Disease in the Absence of Objective Evidence of Active Inflammation
Conclusions: One third of previously biologic-naïve patients had anti-TNF doses increased within the first 12 months of treatment. Dose augmentation frequently occurred in the absence of objective evidence of inflammatory disease activity. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Long-term Outcomes of Per-oral Endoscopic Myotomy in Spastic Esophageal Motility Disorders: A Large, Single-Center Study
Conclusions: POEM is a safe, effective, and durable treatment modality for spastic motility disorders of the esophagus. However, GERD is found in about half of the patients mandating close monitoring after POEM. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research