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Radiologic Predictors of Increased Number of Necrosectomies During Endoscopic Management of Walled-off Pancreatic Necrosis
Goals: No established methods exist to predict who will require a higher number of endoscopic necrosectomy sessions for walled-off necrosis (WON). We aim to identify radiologic predictors for requiring a greater number of necrosectomy sessions. This may help to identify patients who benefit from aggressive endoscopic management. Materials and Methods: This is a multicenter retrospective study of patients with WON at 3 tertiary care centers. WON characteristics on preintervention computed tomography imaging were evaluated to determine if they were predictive of requiring more endoscopic necrosectomy. Results: ...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Article Source Type: research

Improving Medication Tolerance: A Pilot Study in Disorders of Gut-brain Interaction Treated With Tricyclic Antidepressants
Objectives: Tricyclic antidepressants (TCAs) are commonly used to treat disorders of gut-brain interaction (DGBI). However, these medications are often associated with side effects that lead to early treatment discontinuation. Research in other chronic medical conditions suggests that many TCA side effects may be caused by nocebo (negative placebo) effects. The current study tests a brief, verbal intervention aimed at improving tolerance of TCAs in DGBI by providing education about nocebo effects. Materials and Methods: This pilot randomized controlled trial was performed in a tertiary care gastroenterology clin...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal Symptoms
Conclusion: A novel 5-strain probiotic blend improved functional GI symptoms and was safe. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Rectal Evacuation Disorders are Associated With Poor Bowel Preparation in Patients With Chronic Constipation: Results From Two Centers
Conclusions: Among a cohort of patients with chronic constipation undergoing colonoscopy, outlet dysfunction was associated with suboptimal bowel preparation and other quality metrics. Constipated patients with a rectal evacuation disorder may represent a subgroup of patients that could benefit from individualized strategies for better bowel preparation. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Video Consent for Colonoscopy Improves Knowledge Retention and Patient Satisfaction: A Randomized Controlled Study
Conclusion: Patients undergoing screening and diagnostic colonoscopies who received informed consent supplemented by a video tool had a higher recall of core aspects of informed consent and higher satisfaction with the process, with no impact on procedural times. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

A Pilot Randomized Trial of Polypectomy Techniques for 4 to 6 mm Colonic Polyps
Background and Goals: There is variation in polypectomy techniques for resection of small polyps. Aim was to compare techniques for 4 to 6 mm polyps for recurrent adenoma, efficiency, and adverse events and to establish methodological factors for definitive trial. Materials and Methods: The study was a randomized controlled trial. Outpatients with ≥1, 4 to 6 mm polyps were randomized to cold forceps (CF), cold snare (CS), and hot snare (HS). Polypectomy site was marked with SPOT to assess for recurrence at the original polypectomy site during surveillance colonoscopy. To assess feasibility of a definitive ...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Colorectal Neoplasia Detection in Individuals With Positive Multitarget Stool DNA Tests: Data From the New Hampshire Colonoscopy Registry
Background: The US Preventive Services Task Force (USPSTF) includes multitarget stool DNA (mt-sDNA) testing as a colorectal cancer (CRC) screening option in average-risk individuals, but data on colonoscopy outcomes after positive mt-sDNA tests in community settings are needed. Aim: The aim of this study was to investigate colonoscopy outcomes and quality following positive mt-sDNA in the population-based New Hampshire Colonoscopy Registry. Methods: We compared colonoscopy outcomes and quality between age-matched, sex-matched, and risk-matched patients from 30 endoscopy practices with and without a preced...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Evaluation of Endoscopic Practices and Outcomes in Follow-up of Gastric Ulcers
Conclusions: Seven percent of new gastric ulcers were malignant with most identified with biopsy on initial gastroscopy. Malignancy yield from follow-up gastroscopy was 2%. Diagnostic yield of endoscopic follow-up may be low in ulcers with benign appearance and adequate histology. However, current practice of repeat gastroscopy is warranted in the absence of patient-based and lesion-based predictors of malignancy. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Evaluation of Minimal Change Lesions Using Linked Color Imaging in Patients With Nonerosive Reflux Esophagitis
Background and Aims: High prevalence of minimal change lesion (MCL) in nonerosive reflux esophagitis (NERD) patients is commonly recognized by many endoscopists. However, it is difficult to detect MCL with conventional white-light imaging (WLI) endoscopy. Linked color imaging (LCI), a novel image-enhanced endoscopy technology with strong, unique color enhancement, is used for easy recognition of early gastric cancer and detection of Helicobacter pylori infection. The aim of the study was to compare the efficacy of LCI and WLI endoscopy in evaluating MCL in patients with NER. Materials and Methods: Forty-one pati...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

A Prospective Trial to Access the Optimal Circumference of Resection in Antireflux Mucosectomy for Treatment-refractory GERD
Objective: There is still no gold standard regarding the optimal circumference of antireflux mucosectomy (ARMS) in patients with treatment-refractory gastroesophageal reflux disease (GERD). The aim of this study is to assess the safety and effectiveness of resection procedures when the circumferences are different. Patients and Methods: Thirty-two patients with treatment-refractory GERD were allocated into group A (16 cases) and group B (16 cases) by randomization. In group A and group B, a 2/3 and 1/2 circumference, 1.5 cm wide mucosal resection of the gastric cardia was performed. Health-related quality of l...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Association Between Gastroesophageal Flap Valve and Endoscopically Diagnosed Gastroesophageal Reflux Disease According to Lyon Consensus: A Meta-analysis of Asian Studies
Background: Lyon Consensus altered the previous understanding of endoscopic gastroesophageal reflux disease (GERD) and pointed out that only high-grade reflux esophagitis (RE) [Los Angeles (LA) grades C or D], Barrett’s esophagus or peptic stricturing were considered confirmatory evidence for GERD but low-grade RE (LA grades A or B) was regarded as suspected GERD. We aimed to summarize the possible relationship between gastroesophageal flap valve (GEFV) and endoscopic GERD according to Lyon Consensus using meta-analysis of studies done in Asia. Materials and Methods: Comprehensive searches of PubMed, WOS, Emba...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Association Between Sex Hormone Levels and Gut Microbiota Composition and Diversity—A Systematic Review
Conclusions: The findings gathered highlight an association between sex hormones and the gut microbiota composition/diversity and may contribute to the sex-based variations observed in disease pathogenesis. Factors such as age and medical conditions are implicated in the associations observed and should be accounted for in future studies. As the understanding of the complex symbiotic relationship between humans and their gut microbiota increases, microbiota modulation could be an attractive option for the prevention and treatment of gastrointestinal disorders. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

The Discrepancy Between Subjective and Objective Clinical Endpoints in Gastroesophageal Reflux Disease
Therapeutic outcome in gastroesophageal reflux disease (GERD) is commonly determined by both subjective and objective clinical endpoints. Clinicians frequently use symptom improvement as a key benchmark of clinical success, in conjunction with normalization of objective parameters such as esophageal acid exposure and inflammation. However, GERD therapeutic trials have demonstrated that a substantial number of patients rendered asymptomatic, whether through medical, surgical, or endoscopic intervention, continue to have persistent abnormal esophageal acid exposure and erosive esophagitis. The opposite has also been demonstr...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Clinical Reviews Source Type: research

Spatial-temporal Distribution and Influencing Factors of Helicobacter pylori Infection in Chinese Mainland, 2001-2020: A Systematic Review and Meta-Analysis
Conclusions: The prevalence of H. pylori is decreasing in Chinese mainland, but still high in underdeveloped areas. Appropriate strategies for the prevention need greater attention. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Online Article: Clinical Review Source Type: research

World Gastroenterology Organisation (WGO) News and Events
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: WGO News Source Type: research