The scientific career and life of Edmond H. Fischer —A personal tribute
(Source: IUBMB Life)
Source: IUBMB Life - December 9, 2022 Category: Research Authors: Philip Cohen Tags: SPECIAL ISSUE Source Type: research
Genetic tools to dissect functions of long noncoding RNAs
AbstractLncRNAs represent an abundant group of noncoding transcripts, some of which carry out important regulatory functions. To survey the biological and molecular roles of lncRNAs, reliable strategies for their genetic inactivation are required. Several lncRNA features make them challenging to target by genome editing. First, lncRNA loci often span large genomic distances. As such, full or partial deletion alleles are not always easy to generate and interpret as they might affect DNA regulatory elements. Second, in contrast to proteins, lncRNA transcripts are usually resistant to the minimally invasive approach of point ...
Source: IUBMB Life - December 7, 2022 Category: Research Authors: Anna Nawrocka,
Vedrana Andric,
Alena Shkumatava Tags: SPECIAL ISSUE Source Type: research
Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn
AbstractAtherosclerosis, a chronic inflammatory disease that often leads to myocardial infarction and stroke, is mainly caused by lipid accumulation. Eukaryotic initiation factor 6 (Eif6) is a rate-limiting factor in protein translation of transcription factors necessary for lipogenesis. To determine whetherEif6 affects atherosclerosis,Eif6+/ − mice were crossed intoApoe −/− background.Apoe −/−/Eif6+/− mice on high fat diet showed significant reduction in atherosclerotic lesions and necrotic core content in aortic root sections in comparison withApoe −/− mice. RNA-Seq was used to investigate the effect of E...
Source: IUBMB Life - December 6, 2022 Category: Research Authors: Yang Chen,
Zhenzhen Wang,
Xuemei Xian,
Yun Zhuang,
Jiajia Chang,
Xiaoqiang Zhan,
Xufeng Han,
Quangang Chen,
Zhangping Yang,
Renjin Chen Tags: RESEARCH ARTICLE Source Type: research
Machine learning applications for transcription level and phenotype predictions
AbstractPredicting phenotypes and complex traits from genomic variations has always been a big challenge in molecular biology, at least in part because the task is often complicated by the influences of external stimuli and the environment on regulation of gene expression. With today's abundance of omic data and advances in high-throughput computing and machine learning (ML), we now have an unprecedented opportunity to uncover the missing links and molecular mechanisms that control gene expression and phenotypes. To empower molecular biologists and researchers in related fields to start using ML for in-depth analyses of th...
Source: IUBMB Life - November 30, 2022 Category: Research Authors: Juthamard Chantaraamporn,
Pongpannee Phumikhet,
Sarintip Nguantad,
Todsapol Techo,
Varodom Charoensawan Tags: SPECIAL ISSUE Source Type: research
Role of extracellular vesicles in mitochondrial eye diseases
AbstractExtracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogenesis of certain diseases such as cancer is well established, EVs role in ocular health and disease is still at early stages of investigation. Given the significant role of EVs in pathological development and progression of diseases such as cancer, EVs present a similar opportunity for investigation in ocular pathophysiology. Studies have shown the presence of EVs in fluids from the ocular environment have close links with ocular health and disease. Hence, the cargo carried in EVs from ocu...
Source: IUBMB Life - November 30, 2022 Category: Research Authors: Sushma Anand,
Ian A. Trounce,
Lahiru Gangoda Tags: SPECIAL ISSUE Source Type: research
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation
AbstractWhen p62/Sequestosome-1 binds to a ubiquitinated protein, it undergoes liquid –liquid phase separation (LLPS) and forms a membraneless organelle, p62 body. There are two major physiological functions of the p62 body. One is effective autophagic degradation of ubiquitinated proteins and the other is antioxidant stress response, both of which contribute to cellular homeostasi s. In this review, I review the history of p62 research in relation to autophagy and outline the formation, degradation, and physiological functions of the p62 body. (Source: IUBMB Life)
Source: IUBMB Life - November 30, 2022 Category: Research Authors: Masaaki Komatsu Tags: SPECIAL ISSUE Source Type: research
Involvement of sialoglycans in SARS ‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors
AbstractViral infections have been the causes of global pandemics, including the ongoing coronavirus disease 2019, which prompted the investigation into the infection mechanisms to find treatment and aid the vaccine design. Betacoronaviruses use spike glycoprotein on their surface to bind to host receptors, aiding their host attachment and cell fusion. Protein-glycan interaction has been implicated in the viral entry mechanism of many viruses and has recently been shown in SARS-CoV-2. Here, we reviewed the current knowledge on protein-glycan interactions that facilitate SARS-CoV-2 host entry, with special interest in sialo...
Source: IUBMB Life - November 30, 2022 Category: Research Authors: Sakonwan Kuhaudomlarp,
Anne Imberty Tags: SPECIAL ISSUE Source Type: research
Reflections on the 50 ‐year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)
AbstractThe Federation of Asian and Oceanian Biochemists and Molecular Biologists, Inc. (FAOBMB) celebrates its Golden Jubilee in 2022. Established in August 1972 as a regional grouping of three national societies of biochemists in Australia, India and Japan, it took the name Federation of Asian and Oceanian Biochemists (FAOB). The Federation rapidly grew to encompass another 12 national societies (or groups) of biochemists within 6 years, eventually increasing the number of Constituent Members to 21 by 2014. FAOB soon established regular scientific meetings, including triennial Congresses and annual Symposia; from 1980...
Source: IUBMB Life - November 30, 2022 Category: Research Authors: Phillip Nagley,
Jisnuson Svasti,
Akira Kikuchi Tags: SPECIAL ISSUE Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - November 30, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research
A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972 –2022)
(Source: IUBMB Life)
Source: IUBMB Life - November 30, 2022 Category: Research Authors: Akira Kikuchi,
Zengyi Chang,
Paul A. Gleeson Tags: EDITORIAL Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - November 30, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research
MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer
ConclusionsMST4, as an autophagy-associated protein, plays a potential role in inducing cell death by increasing protein content in radiotherapy. (Source: IUBMB Life)
Source: IUBMB Life - November 23, 2022 Category: Research Authors: Xiuhua Shi,
Junwei Zou,
Yinhua Wang,
Jian Zhao,
Bin Ye,
Qinghua Qi,
Fei Liu,
Jun Hu,
Shu Li,
Ye Tian Tags: RESEARCH ARTICLE Source Type: research
A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972 –2022)
(Source: IUBMB Life)
Source: IUBMB Life - November 23, 2022 Category: Research Authors: Akira Kikuchi,
Zengyi Chang,
Paul A. Gleeson Tags: EDITORIAL Source Type: research
