Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high ‐fat diet
AbstractObesity is caused by an imbalance between calorie intake and energy expenditure, leading to excessive adipose tissue accumulation. Nicotinamide adenine dinucleotide (NAD+) is an important molecule in energy and signal transduction, and NAD+ supplementation therapy is a new treatment for obesity in recent years. Liver kinase B1 (LKB1) is an energy metabolism regulator. The relationship between NAD+ and LKB1 has only been studied in the heart and has not yet been reported in obesity. Nicotinamide mononucleotide (NMN), as a direct precursor of NAD+, can effectively enhance the level of NAD+. In the current study, we s...
Source: IUBMB Life - February 14, 2023 Category: Research Authors: Yan Zhang,
Wenjuan Zhu,
Meng Wang,
Pengjiao Xi,
Haomin Wang,
Derun Tian Tags: RESEARCH ARTICLE Source Type: research
Activation of E3 ubiquitin ligase WWP2 by non ‐receptor tyrosine kinase ACK1
In this report, we have found that non-receptor TK ACK1 binds to the WW3 domain of WWP2 and phosphorylates WWP2. ACK1 phosphorylates WWP2 at the 2, 3-linker and partially activates the ubiquitination ligase activity. Unexpectedly, tyrosine phosphorylation of the 2, 3-linker seems not a major mode for activation of WWP2, as ACK1 causes much higher activation of the 2, 3-linker tyrosine phosphorylation defective mutants of WWP2 than that of wild-type WWP2. Furthermore, epidermal growth factor (EGF) stimulates tyrosine phosphorylation of WWP2 and this EGF-stimulated phosphorylation of WWP2 is mediated by ACK1. Finally, knockd...
Source: IUBMB Life - February 14, 2023 Category: Research Authors: Jun Zhu,
Ziluo Peng,
Xianyan Tian,
Tiantian Wu,
Aiqin Sun,
Wannian Yang,
Qiong Lin Tags: RESEARCH ARTICLE Source Type: research
Correction to “The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland”
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Source: IUBMB Life - February 9, 2023 Category: Research Tags: CORRIGENDUM Source Type: research
Correction to “”
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Source: IUBMB Life - January 31, 2023 Category: Research Tags: CORRIGENDUM Source Type: research
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On the Cover: Expanding role of ribosome-inactivating proteins: From toxins to therapeutics by Sharma et al.; Article first published: 7 October 2022;https://doi.org/10.1002/iub.2675 (Source: IUBMB Life)
Source: IUBMB Life - January 31, 2023 Category: Research Authors: Anuj Sharma,
Shelly Gupta,
Neeta Raj Sharma,
Karan Paul Tags: COVER IMAGE Source Type: research
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Source: IUBMB Life - January 31, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
Issue Highlights
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Source: IUBMB Life - January 31, 2023 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research
Correction to “”
(Source: IUBMB Life)
Source: IUBMB Life - January 31, 2023 Category: Research Tags: CORRIGENDUM Source Type: research
Cover Image
On the Cover: Expanding role of ribosome-inactivating proteins: From toxins to therapeutics by Sharma et al.; Article first published: 7 October 2022;https://doi.org/10.1002/iub.2675 (Source: IUBMB Life)
Source: IUBMB Life - January 31, 2023 Category: Research Authors: Anuj Sharma,
Shelly Gupta,
Neeta Raj Sharma,
Karan Paul Tags: COVER IMAGE Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - January 31, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
Issue Highlights
(Source: IUBMB Life)
Source: IUBMB Life - January 31, 2023 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research
Neonatal exposure to low ‐dose X‐ray causes behavioral defects and abnormal hippocampal development in mice
AbstractDevelopment of the hippocampus is critical for its normal maturation. However, there is no systematic study on the effects of low-dose ( ≤2 Gy) neonatal X-ray exposure on different cells at different developmental stages of the mouse hippocampus. The present study demonstrated that irradiation with 2 Gy at postnatal day (PD) 3 in mice induced anxiety and impairment of spatial learning and memory in adult mice. Neuroinflammatory c ells were observed in the dentate gyrus (DG) and CA3 areas of the hippocampus at PD3 + 1. X-ray irradiation impaired neuronal complexity and neurogenesis. However, the number of as...
Source: IUBMB Life - January 12, 2023 Category: Research Authors: Yuanduo Liu,
Hongying Ma,
Yangyang Wang,
Boxu Ren,
Lian Liu,
Anbang Sun,
Fengru Tang Tags: RESEARCH ARTICLE Source Type: research
