Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS ‐COV‐2 targeting main protease and papain‐like protease
AbstractThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be over, but its variants continue to emerge, and patients with mild symptoms having long COVID is still under investigation. SARS-CoV-2 infection leading to elevated cytokine levels and suppressed immune responses set off cytokine storm, fatal systemic inflammation, tissue damage, and multi-organ failure. Thus, drug molecules targeting the SARS-CoV-2 virus-specific proteins or capable of suppressing the host inflammatory responses to viral infection would provide an effective antiviral thera...
Source: IUBMB Life - December 8, 2023 Category: Research Authors: Shweta Choudhary, Sanketkumar Nehul, Ankur Singh, Prasan Kumar Panda, Pravindra Kumar, Gaurav Kumar Sharma, Shailly Tomar Tags: SPECIAL ISSUE Source Type: research

Amino acid deprivation induces TXNIP expression by NRF2 downregulation
AbstractThioredoxin-interacting protein (TXNIP) is sensitive to oxidative stress and is involved in the pathogenesis of various metabolic, cardiovascular, and neurodegenerative disorders. Therefore, several studies have suggested that TXNIP is a promising therapeutic target for several diseases, particularly cancer and diabetes. However, the regulation of TXNIP expression under amino acid (AA)-restricted conditions is not well understood. In the present study, we demonstrated that TXNIP expression was promoted by the deprivation of AAs, especially arginine, glutamine, lysine, and methionine, in non-small cell lung cancer (...
Source: IUBMB Life - December 7, 2023 Category: Research Authors: Se Hee Ahn, Se ‐Kyeong Jang, Yu Jin Kim, Gyeongmi Kim, Ki Soo Park, In‐Chul Park, Hyeon‐Ok Jin Tags: RESEARCH ARTICLE Source Type: research

Fingolimod (FTY720), an FDA ‐approved sphingosine 1‐phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue virus serotype 2 infection
AbstractExtensive vascular leakage and shock is a major cause of dengue-associated mortality. At present, there are no specific treatments available. Sphingolipid pathway is a key player in the endothelial barrier integrity; and is mediated through the five sphingosine-1-phosphate receptors (S1PR1-S1PR5). Signaling through S1PR2 promotes barrier disruption; and in Dengue virus (DENV)-infection, there is overexpression of this receptor. Fingolimod (FTY720) is a specific agonist that targets the remaining barrier-protective S1P receptors, without targeting S1PR2. In the present study, we explored whether FTY720 treatment can...
Source: IUBMB Life - December 1, 2023 Category: Research Authors: Ayan Modak, Srishti Rajkumar Mishra, Mansi Awasthi, Arya Aravind, Sneha Singh, Easwaran Sreekumar Tags: SPECIAL ISSUE Source Type: research

Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - November 30, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research

Cover Image
On the Cover: Mitochondrial morphology of tendon-derived stem cells upon glycolipotoxicity induced ferroptosis by Wang et al.; Article first published: 28 Jul 2023;https://doi.org/10.1002/iub.2771 (Source: IUBMB Life)
Source: IUBMB Life - November 29, 2023 Category: Research Tags: COVER IMAGE Source Type: research

Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - November 29, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research

Cover Image
On the Cover: Mitochondrial morphology of tendon-derived stem cells upon glycolipotoxicity induced ferroptosis by Wang et al.; Article first published: 28 Jul 2023;https://doi.org/10.1002/iub.2771 (Source: IUBMB Life)
Source: IUBMB Life - November 29, 2023 Category: Research Tags: COVER IMAGE Source Type: research

Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells
AbstractMesenchymal stem cells (MSCs) are a therapeutically efficient type of stem cells validated by their ability to treat many inflammatory and chronic conditions. The biological and therapeutic characteristics of MSCs can be modified depending on the type of microenvironment at the site of transplantation. Diabetes mellitus (DM) is a commonly diagnosed metabolic disease characterized by hyperglycemia, which alters over time the cellular and molecular functions of many cells and causes their damage. Hyperglycemia can also impact the success rate of MSCs transplantation; therefore, it is extremely significant to investig...
Source: IUBMB Life - November 29, 2023 Category: Research Authors: Ramada R. Khasawneh, Ejlal Abu ‐El‐Rub, Fatimah A. Almahasneh, Ayman Alzu'bi, Hana M. Zegallai, Rawan A. Almazari, Huthaifa Magableh, Mohammad H. Mazari, Haitham F. Shlool, Ahmad K. Sanajleh Tags: RESEARCH ARTICLE Source Type: research

Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children
AbstractThe 5-methylcytosine (m5C) is the key chemical modification in RNAs. As one of the demethylases in m5C, TET2 has been shown as a tumor suppressor. However, the impact ofTET2 gene polymorphisms on neuroblastoma has not been elucidated. 402 neuroblastoma patients and 473 controls were genotyped forTET2 gene polymorphisms using the TaqMan method. The impact ofTET2 gene polymorphisms on neuroblastoma susceptibility was determined using multivariate logistic regression analysis. We also adopted genotype-tissue expression database to explore the impact ofTET2 gene polymorphisms on the expression of host and nearby genes....
Source: IUBMB Life - November 28, 2023 Category: Research Authors: Lei Lin, Bo Wang, Xinxin Zhang, Changmi Deng, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He Tags: RESEARCH ARTICLE Source Type: research

Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis
AbstractVincristine (VCR) is a microtubule-destabilizing chemotherapeutic agent commonly administered for the treatment of cancers in patients, which can induce severe side effects including neurotoxicity. In context of the effects on female fertility, ovarian toxicity has been found in patients and mice model after VCR exposure. However, the influence of VCR exposure on oocyte quality has not been elucidated. We established VCR exposure in vitro and in vivo model. The results indicated in vitro VCR exposure contributed to failure of oocyte maturation through inducing defects in spindle assembly, activation of SAC, oxidati...
Source: IUBMB Life - November 28, 2023 Category: Research Authors: Haoya Chang, Siyu Cheng, Guoqiang Xing, Chenyang Huang, Chunhui Zhang, Weiping Qian, Jian Li Tags: RESEARCH ARTICLE Source Type: research