Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow
AbstractIn October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID had disrupted and restricted preparations for the gathering, which ultimately was held via ZOOM. Nevertheless, it was a wonderful opportunity to share a day with Eddy, an exceptional scientist and true renaissance man, and to appreciate his stellar contributions to science. Eddy Fischer, together with Ed Krebs, was responsible for the discovery of reversible protein phosphorylation, which launched the entire field of signal transduction. The importance of this seminal work is now bein...
Source: IUBMB Life - March 27, 2023 Category: Research Authors: Nicholas K. Tonks Tags: SPECIAL ISSUE Source Type: research
Cover Image
On the Cover: Volker Steger/Lindau Nobel Laureate Meetings – from: Sketches of Science – Photo Sessions with Nobel Laureates, Berliner Wissenschafts-Verlag, 2022, ISBN 978-3-8305-5176-8 (Source: IUBMB Life)
Source: IUBMB Life - March 27, 2023 Category: Research Tags: COVER IMAGE Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - March 27, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow
AbstractIn October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID had disrupted and restricted preparations for the gathering, which ultimately was held via ZOOM. Nevertheless, it was a wonderful opportunity to share a day with Eddy, an exceptional scientist and true renaissance man, and to appreciate his stellar contributions to science. Eddy Fischer, together with Ed Krebs, was responsible for the discovery of reversible protein phosphorylation, which launched the entire field of signal transduction. The importance of this seminal work is now bein...
Source: IUBMB Life - March 27, 2023 Category: Research Authors: Nicholas K. Tonks Tags: SPECIAL ISSUE Source Type: research
Anti ‐inflammatory effects of sodium‐glucose cotransporter‐2 inhibitors in COVID‐19
AbstractThe ongoing pandemic of COVID-19 is intrinsically a systemic inflammatory disorder; hence, those patients suffering an underlying chronic inflammatory disease such as diabetes mellitus are at high risk of severe complications. Preventing or suppressing the inflammatory responses are of importance in diabetic patients. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are a newly introduced anti-diabetic drugs that have hypoglycemic effects through the urinary excretion of glucose. They also have an anti-inflammatory potential in diabetes patients, in addition to improving glycemic control, and while there is no d...
Source: IUBMB Life - March 27, 2023 Category: Research Authors: Habib Yaribeygi,
Mina Maleki,
Stephen L. Atkin,
Prashant Kesharwani,
Tannaz Jamialahmadi,
Amirhossein Sahebkar Tags: CRITICAL REVIEW Source Type: research
A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer
AbstractLong noncoding RNAs (lncRNAs) are emerging players in cancer and they entail potential as prognostic biomarkers or therapeutic targets. Earlier studies have identified somatic mutations in lncRNAs that are associated with tumor relapse after therapy, but the underlying mechanisms behind these associations remain unknown. Given the relevance of secondary structure for the function of some lncRNAs, some of these mutations may have a functional impact through structural disturbance. Here, we examined the potential structural and functional impact of a novel A > G point mutation inNEAT1 that has been recurrent...
Source: IUBMB Life - March 27, 2023 Category: Research Authors: Efe Ayd ın,
Ester Saus,
Uciel Chorostecki,
Toni Gabaldón Tags: SPECIAL ISSUE Source Type: research
FOXC2 ‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression
In conclusion, circCASK induced by FOXC2 accelerated CRC progression through the miR-1271-5p/SIX1 axis, thus providing an interesting insight into CRC tumorigenesis. (Source: IUBMB Life)
Source: IUBMB Life - March 25, 2023 Category: Research Authors: Junwei Zou,
Yong Huang,
Yuan Chen,
Zhaoying Wu,
Hao Xie,
Hailang Zhou,
Chungen Xing Tags: RESEARCH ARTICLE Source Type: research
Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer
(Source: IUBMB Life)
Source: IUBMB Life - March 25, 2023 Category: Research Authors: Alexandra C. Newton,
Dario R. Alessi Tags: SPECIAL ISSUE Source Type: research
FOXC2 ‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression
In conclusion, circCASK induced by FOXC2 accelerated CRC progression through the miR-1271-5p/SIX1 axis, thus providing an interesting insight into CRC tumorigenesis. (Source: IUBMB Life)
Source: IUBMB Life - March 24, 2023 Category: Research Authors: Junwei Zou,
Yong Huang,
Yuan Chen,
Zhaoying Wu,
Hao Xie,
Hailang Zhou,
Chungen Xing Tags: RESEARCH ARTICLE Source Type: research
Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer
(Source: IUBMB Life)
Source: IUBMB Life - March 12, 2023 Category: Research Authors: Alexandra C. Newton,
Dario R. Alessi Tags: SPECIAL ISSUE Source Type: research
Retraction
(Source: IUBMB Life)
Source: IUBMB Life - March 11, 2023 Category: Research Tags: RETRACTION Source Type: research
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta ‐analysis
ConclusionsThis meta-analysis indicated that polymorphisms in the PI3K/Akt pathway in eNOS rs1799983, rs869109213, rs2070744, and IL-6 rs1800796 were related to the increased risk of DKD. (Source: IUBMB Life)
Source: IUBMB Life - March 2, 2023 Category: Research Authors: Hang Fu,
Congcong Guo,
Jing Zhang,
Lusi Xu,
Shan Jiang,
Siyi Guo,
Qiqi Sheng,
Junyu Zhao,
Lin Liao Tags: RESEARCH ARTICLE Source Type: research
