Reflections on the 50 ‐year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)
AbstractThe Federation of Asian and Oceanian Biochemists and Molecular Biologists, Inc. (FAOBMB) celebrates its Golden Jubilee in 2022. Established in August 1972 as a regional grouping of three national societies of biochemists in Australia, India and Japan, it took the name Federation of Asian and Oceanian Biochemists (FAOB). The Federation rapidly grew to encompass another 12 national societies (or groups) of biochemists within 6  years, eventually increasing the number of Constituent Members to 21 by 2014. FAOB soon established regular scientific meetings, including triennial Congresses and annual Symposia; from 1980...
Source: IUBMB Life - October 27, 2022 Category: Research Authors: Phillip Nagley, Jisnuson Svasti, Akira Kikuchi Tags: SPECIAL ISSUE Source Type: research

Issue Highlights
(Source: IUBMB Life)
Source: IUBMB Life - October 22, 2022 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - October 21, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research

Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - October 21, 2022 Category: Research Authors: Alicja Martyniak, Mateusz Je ż, Józef Dulak, Jacek Stępniewski Tags: SPECIAL ISSUE Source Type: research

Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt ‐driven signaling pathway
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - October 20, 2022 Category: Research Authors: Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Jae ‐Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S Rangappa, Kwang Seok Ahn Tags: Research Article Source Type: research

MST4 as a Novel Therapeutic Target for Autophagy and Radiosensitivity in Gastric Cancer
ConclusionsMST4, as an autophagy-associated protein, plays a potential role in inducing cell death by increasing protein content in radiotherapy. (Source: IUBMB Life)
Source: IUBMB Life - October 15, 2022 Category: Research Authors: Xiuhua Shi, Junwei Zou, Yinhua Wang, Jian Zhao, Bin Ye, Qinghua Qi, Fei Liu, Jun Hu, Shu Li, Ye Tian Tags: ARTICLE Source Type: research

Phosphorylase Phosphatase and Flash Activation of Skeletal Muscle Glycogen Phosphorylase – A Tribute to Edmond H. Fischer
AbstractGlycogen is a polymerized form of glucose that serves as an energy reserve in all types of organisms. In animals glycogen synthesis and degradation, especially in liver and skeletal muscle, are regulated by hormonal and physiological signals that reciprocally control the opposing activities of glycogen synthase and glycogen phosphorylase. These enzymes are under allosteric control by binding of metabolites (e.g. ATP, AMP, G6P) and covalent control by reversible phosphorylation by kinase and phosphatase all assembled together on glycogen. More than 50  years ago Edmond Fischer and colleagues showed “flash activa...
Source: IUBMB Life - October 14, 2022 Category: Research Authors: David L. Brautigan Tags: SPECIAL ISSUE Source Type: research

Mechanisms of epigenetic regulation of transcription by lncRNAs in plants
AbstractLong noncoding RNAs (lncRNAs) are a ubiquitous feature of eukaryotic genomes, and in recent decades have been shown to be highly abundant and varied. Many prominent examples have been described as having essential roles in regulating the expression of genes in different developmental and environmental contexts. As a result, much work has been done on elucidating the mechanisms by which they modulate the expression of protein coding genes. In this review, we focus on those which have been characterized in plants. We specifically examine common epigenetic mechanisms which regulate gene expression at the level of tran...
Source: IUBMB Life - October 12, 2022 Category: Research Authors: Benjamin J.M. Tremblay, Julia I. Q üesta Tags: SPECIAL ISSUE Source Type: research

Retraction
(Source: IUBMB Life)
Source: IUBMB Life - October 11, 2022 Category: Research Tags: RETRACTION Source Type: research

Phosphorylation, compartmentalization, and cardiac function
This article primarily focuse s on A kinase anchoring protein (AKAP) signaling in the heart with an emphasis on anchoring proteins that spatiotemporally coordinate excitation-contraction coupling and hypertrophic responses. (Source: IUBMB Life)
Source: IUBMB Life - October 8, 2022 Category: Research Authors: Kerrie B. Collins, John D. Scott Tags: SPECIAL ISSUE Source Type: research

N6 ‐methyladenosine regulators are potential prognostic biomarkers for multiple myeloma
This study aimed to create an m6A RNA regulators prognostic signature for MM patients. We integrated data from the Multiple Myeloma Research Foundation CoMMpass Study and the Genotype-Tissue Expression database to analyze gene expression profiles of 21  m6A regulators. Consistent clustering analysis was used to identify the clusters of patients with MM having different clinical outcomes. Gene distribution was analyzed using principal component analysis. Next, we generated an mRNA gene signature of m6A regulators using a multivariate logistic reg ression model with least absolute shrinkage and selection operator. The expr...
Source: IUBMB Life - October 8, 2022 Category: Research Authors: Jing Wang, Yifan Zuo, Chenglan Lv, Min Zhou, Yuan Wan Tags: ARTICLE Source Type: research

Novel NRF2 ‐activated cancer treatments utilizing synthetic lethality
AbstractThe KEAP1-NRF2 pathway regulates the main inducible cellular response to oxidative and electrophilic stresses. Activating mutations in the KEAP1-NRF2 pathway occur commonly in human cancer, where they contribute to the formation of aggressive tumours that are associated with a poor prognosis for patients. An important clinical feature of these tumours is their defiance to all current anti-cancer treatment regimens, highlighting the need for the development of new therapeutic strategies to target NRF2-activated cancers. In this review, we discuss the mechanisms through which acquired NRF2 hyperactivation can result ...
Source: IUBMB Life - October 6, 2022 Category: Research Authors: Liam Baird, Thomas W. Kensler, Masayuki Yamamoto Tags: SPECIAL ISSUE Source Type: research

N6 ‐methyladenosine regulators are potential prognostic biomarkers for multiple myeloma
This study aimed to create an m6A RNA regulators prognostic signature for MM patients. We integrated data from the Multiple Myeloma Research Foundation CoMMpass Study and the Genotype-Tissue Expression database to analyze gene expression profiles of 21 m6A regulators. Consistent clustering analysis was used to identify the clusters of patients with MM having different clinical outcomes. Gene distribution was analyzed using principal component analysis. Next, we generated an mRNA gene signature of m6A regulators using a multivariate logistic regression model with least absolute shrinkage and selection operator. The expressi...
Source: IUBMB Life - September 30, 2022 Category: Research Authors: Jing Wang, Yifan Zuo, Chenglan Lv, Min Zhou, Yuan Wan Tags: ARTICLE Source Type: research