Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - January 30, 2024 Category: Research Tags: ISSUE INFORMATION Source Type: research
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On the Cover: Asymmetric inheritance of aging determinants during cell division in budding yeast. by Yang et al.; Article first published: 20 Sept 2023;https://doi.org/10.1002/iub.2783 (Source: IUBMB Life)
Source: IUBMB Life - January 30, 2024 Category: Research Tags: COVER IMAGE Source Type: research
Screening and experimental validation of diagnostic gene in ulcerative colitis with anti ‐TNF‐α therapy
AbstractIn clinical practice, the diagnosis of ulcerative colitis (UC) mainly relies on a comprehensive analysis of a series of signs and symptoms of patients. The current biomarkers for diagnosis of UC and prognostic prediction of anti-TNF- α therapy are inaccurate. The present study aimed to perform an integrative analysis of gene expression profiles in patients with UC. A total of seven datasets from the GEO database that met our strict inclusion criteria were included. After identifying differentially expressed genes (DEGs) between UC patients and healthy individuals, the diagnostic and prognostic utility of the DEGs ...
Source: IUBMB Life - January 26, 2024 Category: Research Authors: Yuan Chen,
Xinfang Li,
Ran Sun,
Fan Yang,
Weiliang Tian,
Qian Huang Tags: RESEARCH ARTICLE Source Type: research
HNRNPA2B1 promotes oral squamous cell carcinogenesis via m6A ‐dependent stabilization of FOXQ1 mRNA stability
This study accelerates the recognition of the potency of m6A modification in OSCC and paves the path for OSCC's targeted diagnosis and therapy. (Source: IUBMB Life)
Source: IUBMB Life - January 25, 2024 Category: Research Authors: Xi Wang,
Min Zhi,
Wei Zhao,
Jiayin Deng Tags: RESEARCH ARTICLE Source Type: research
MRAS in coronary artery disease —Unchartered territory
AbstractGenome-wide association studies (GWAS) have identified coronary artery disease (CAD) susceptibility locus on chromosome 3q22.3. This locus contains a cluster of several genes that includes muscle rat sarcoma virus (MRAS). CommonMRAS variants are also associated with CAD causing risk factors such as hypertension, dyslipidemia, obesity, and type II diabetes. TheMRAS gene is an oncogene that encodes a membrane-bound small GTPase. It is involved in a variety of signaling pathways, regulating cell differentiation and cell survival (mitogen-activated protein kinase [MAPK]/extracellular signal-regulated kinase and phospha...
Source: IUBMB Life - January 23, 2024 Category: Research Authors: Pashmina Wiqar Shah,
Tobias Reinberger,
Satwat Hashmi,
Zouhair Aherrahrou,
Jeanette Erdmann Tags: CRITICAL REVIEW Source Type: research
Wnt signaling in cell adhesion, development, and colon cancer
AbstractWnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also plays a role in maintaining tissue homeostasis in adult organisms. The loss of normal cell polarity and adhesion caused by Wnt signaling activation is a fundamental step for tumor progression and metastasis. Activating the canonical Wnt pathway is a driving force in many human cancers, especially colorectal, hepatocellular, and mammary carcinomas. Wnt causes the stabilization and nuclear transport of newly synthesized transcriptio...
Source: IUBMB Life - January 18, 2024 Category: Research Authors: Nydia Tejeda ‐Muñoz,
Kuo‐Ching Mei Tags: CRITICAL REVIEW Source Type: research
Matrix ‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma
AbstractOral squamous cell carcinoma (OSCC) is a head and neck cancer (HNC) with a high mortality rate. OSCC is developed in the oral cavity and it is triggered by many etiologic factors and can metastasize both regionally and distantly. Recent research advances in OSCC improved our understanding on the molecular mechanisms involved in and the initiation of OSCC metastasis. The key roles of the extracellular matrix (ECM) in OSCC are an emerging area of intensive research as the ECM macromolecular network is actively involved in events that regulate cellular morphological and functional properties, transcription and cell si...
Source: IUBMB Life - January 3, 2024 Category: Research Authors: Nicholas S. Mastronikolis,
Efthymios Kyrodimos,
Zoi Piperigkou,
Despoina Spyropoulou,
Alexander Delides,
Evangelos Giotakis,
Miranda Alexopoulou,
Nick A. Bakalis,
Nikos K. Karamanos Tags: CRITICAL REVIEW Source Type: research
Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - December 24, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
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On the Cover: Metabolic reconfiguration of respiratory deficient cells by Bui et al.; Article first published:10 August 2023;https://doi.org/10.1002/iub.2775 (Source: IUBMB Life)
Source: IUBMB Life - December 23, 2023 Category: Research Tags: COVER IMAGE Source Type: research
The tumor immune microenvironment remodeling and response to HER2 ‐targeted therapy in HER2‐positive advanced gastric cancer
In this study, we used multiplex immunohistochemistry to assess the changes of the tumor microenvironment in 47 advanced GC patients receiving anti-HER2 therapy. Additionally, we performed single-cell transcriptional sequencing to investigate potential cell-to-cell communication and molecular mechanisms in four HER2-positive GC baseline samples. We observed that post-treated the infiltration of NK cells, CD8+ T cells, and B lymphocytes were significantly higher in patients who benefited from anti-HER2 treatment than baseline. Further spatial distribution analysis demonstrated that the interaction scores between NK cells an...
Source: IUBMB Life - December 22, 2023 Category: Research Authors: Lei Jiang,
Xingwang Zhao,
Yilin Li,
Yajie Hu,
Yu Sun,
Shengde Liu,
Zizhen Zhang,
Yanyan Li,
Xujiao Feng,
Jiajia Yuan,
Jian Li,
Xiaotian Zhang,
Yang Chen,
Lin Shen Tags: RESEARCH ARTICLE Source Type: research
