Recent advances in BCRP ‐induced breast cancer resistance treatment with marine‐based natural products
AbstractBreast cancer is the prominent cause of cancer-related death in women globally in terms of incidence and mortality. Despite, recent advances in the management of breast cancer, there are still a lot of cases of resistance to medicines, which is currently one of the biggest problems faced by researchers across the globe. Out of several mechanisms, breast cancer resistance protein (BCRP) arbitrated drug resistance is a major concern. Hormonal, cytotoxic and immunotherapeutic drugs are used in the systemic therapy of breast cancer. It is vital to choose drugs based on the clinical and molecular attributes of the tumor...
Source: IUBMB Life - July 14, 2023 Category: Research Authors: Jovita Kanoujia, Anjali Das, Neha Raina, Ginpreet Kaur, Sandeep K. Singh, Hardeep S. Tuli, Ashish Garg, Madhu Gupta Tags: SPECIAL ISSUE Source Type: research

Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction ‐induced cardiomyopathy
In conclusion, a molecular program is in place to keep this struct ural remodeling associated with frequent PVCs as an adaptive pathological hypertrophy. (Source: IUBMB Life)
Source: IUBMB Life - July 11, 2023 Category: Research Authors: Jaime Balderas ‐Villalobos, J. M. Lourdes Medina‐Contreras, Christopher Lynch, Rajiv Kabadi, Janée Hayles, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samsó, Jose F. Huizar, Jose M. Eltit Tags: RESEARCH ARTICLE Source Type: research

The long intergenic noncoding RNA ARES modulates root architecture in Arabidopsis
AbstractLong noncoding RNAs (lncRNAs) have emerged as important regulators of gene expression in plants. They have been linked to a wide range of molecular mechanisms, including epigenetics, miRNA activity, RNA processing and translation, and protein localization or stability. In Arabidopsis, characterized lncRNAs have been implicated in several physiological contexts, including plant development and the response to the environment. Here we searched for lncRNA loci located nearby key genes involved in root development and identified the lncRNAARES (AUXIN REGULATOR ELEMENT DOWNSTREAM SOLITARYROOT) downstream of the lateral ...
Source: IUBMB Life - July 7, 2023 Category: Research Authors: Thomas Roul é, María Florencia Legascue, Andana Barrios, Nicolás Gaggion, Martin Crespi, Federico Ariel, Thomas Blein Tags: SPECIAL ISSUE Source Type: research

Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - July 4, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research

Cover Image
On the Cover: Mechanistic diagram of 2-DG inhibiting cervical cancer progression in vitro by Su et al.; Article first published: 21 February 2023;https://doi.org/10.1002/iub.2706 (Source: IUBMB Life)
Source: IUBMB Life - June 20, 2023 Category: Research Tags: COVER IMAGE Source Type: research

Lobeline: A multifunctional alkaloid modulates cholinergic and glutamatergic activities
AbstractDeveloping drugs for Alzheimer's disease (AD) is an extremely challenging task due to its devastating pathology. Previous studies have indicated that natural compounds play a crucial role as lead molecules in the development of drugs. Even though, there are remarkable technological advancements in the isolation and synthesis of natural compounds, the targets for many of them are still unknown. In the present study, lobeline, a piperidine alkaloid has been identified as a cholinesterase inhibitor through chemical similarity assisted target fishing method. The structural similarities between lobeline and donepezil, a...
Source: IUBMB Life - June 20, 2023 Category: Research Authors: Chandran Remya, Kalarickal V. Dileep, Elessery J. Variyar, Ramakrishnapillai V. Omkumar, Chittalakkottu Sadasivan Tags: RESEARCH ARTICLE Source Type: research

Liraglutide ameliorates hepatic steatosis via retinoic acid receptor ‐related orphan receptor α‐mediated autophagy pathway
AbstractLiraglutide, an analog of human glucagon-like peptide-1 (GLP-1), has been found to improve hepatic steatosis in clinical practice. However, the underlying mechanism remains to be fully defined. Increasing evidence suggests that retinoic acid receptor-related orphan receptor α (RORα) is involved in hepatic lipid accumulation. In the current study, we investigated whether the ameliorating impact of liraglutide on lipid-induced hepatic steatosis is dependent on RORα activity and examined the underlying mechanisms. Cre-loxP-mediated, liver-specificRor α knockout (Rora LKO) mice, and littermate controls with aRoralo...
Source: IUBMB Life - June 14, 2023 Category: Research Authors: Xiaoqian Yu, Xiaoqi Bian, Hongmei Zhang, Shanshan Yang, Daxin Cui, Zhiguang Su Tags: RESEARCH ARTICLE Source Type: research