p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation

AbstractWhen p62/Sequestosome-1 binds to a ubiquitinated protein, it undergoes liquid –liquid phase separation (LLPS) and forms a membraneless organelle, p62 body. There are two major physiological functions of the p62 body. One is effective autophagic degradation of ubiquitinated proteins and the other is antioxidant stress response, both of which contribute to cellular homeostasi s. In this review, I review the history of p62 research in relation to autophagy and outline the formation, degradation, and physiological functions of the p62 body.

Source: IUBMB Life - November 30, 2022 Category: Research Authors: Masaaki Komatsu Tags: SPECIAL ISSUE Source Type: research