Occupational exposure to respirable crystalline silica and risk of autoimmune rheumatic diseases: a nationwide cohort study
ConclusionsThis study shows an exposure-dependent association between occupational exposure to respirable crystalline silica and autoimmune rheumatic diseases and thus suggests causal effects, most evident for systemic sclerosis and rheumatoid arthritis. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 18, 2021 Category: Epidemiology Source Type: research

Oestradiol and the risk of myocardial infarction in women: a cohort study of UK Biobank participants
ConclusionsHigher levels of oestradiol were not associated with a decreased risk of MI. The presumed cardioprotective effects of oestradiol seem to be largely confounded by age and further confounded by other cardiovascular risk factors. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 17, 2021 Category: Epidemiology Source Type: research

Duration of diabetes-related complications and mortality in type 1 diabetes: a national cohort study
ConclusionsIn this cohort we show that duration of diabetes-related complications is an important determinant of mortality in type 1 diabetes, for example the MRR associated with CVD is highest in the first period after diagnosis of CVD. A stronger focus on time-updated information and thorough consideration of complication duration may improve risk stratification in routine clinical practice. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 16, 2021 Category: Epidemiology Source Type: research

Cohort Profile Update: Manhi ça Health and Demographic Surveillance System (HDSS) of the Manhiça Health Research Centre (CISM)
(Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 16, 2021 Category: Epidemiology Source Type: research

A systematic review on lagged associations in climate –health studies
ConclusionOur findings indicated some general patterns for possible lagged associations between some common health outcomes and climatic exposures, and suggested a necessity for a biologically plausible and reasonable definition of the effect lag in the modelling practices for future environmental epidemiological studies. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 15, 2021 Category: Epidemiology Source Type: research

Seroprevalence of SARS-CoV-2 antibodies in over 6000 healthcare workers in Spain
ConclusionsSeroprevalence of IgG-SARS-CoV-2 antibodies in HCW is a little higher than in the general population and varies depending on regional COVID-19 incidence. The high rates of subclinical and previously undiagnosed infection observed in this study reinforce the utility of antibody screening. An occupational risk for SARS-CoV-2 infection related to working in a clinical environment was demonstrated in this HCW cohort. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 12, 2021 Category: Epidemiology Source Type: research

Cohort Profile Update: Africa Centre Demographic Information System (ACDIS) and population-based HIV survey
South AfricaepidemiologyHIVpopulation cohort (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 12, 2021 Category: Epidemiology Source Type: research

The combined impact of smoking, obesity and alcohol on life-expectancy trends in Europe
ConclusionWithout the combined impact of smoking, obesity and alcohol, the increase over time in life expectancy at birth would have been smaller among men but larger among women, resulting in a stable increase in e0, parallel for men and women. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 11, 2021 Category: Epidemiology Source Type: research

International comparisons of COVID-19 deaths in the presence of comorbidities require uniform mortality coding guidelines
COVID-19classification of deathsmortality statisticsICD-10politicsnosologyWorld Health Organization (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 11, 2021 Category: Epidemiology Source Type: research

Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II
ConclusionsPrevention should target the most disadvantaged areas, to narrow inequalities, with clear indication from the most advantaged that reduction in poor transitions is achievable. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 9, 2021 Category: Epidemiology Source Type: research

Reflection on modern methods: good practices for applied statistical learning in epidemiology
AbstractStatistical learning includes methods that extract knowledge from complex data. Statistical learning methods beyond generalized linear models, such as shrinkage methods or kernel smoothing methods, are being increasingly implemented in public health research and epidemiology because they can perform better in instances with complex or high-dimensional data —settings in which traditional statistical methods fail. These novel methods, however, often include random sampling which may induce variability in results. Best practices in data science can help to ensure robustness. As a case study, we included four statist...
Source: International Journal of Epidemiology - January 9, 2021 Category: Epidemiology Source Type: research

Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark
ConclusionsOffspring of parents born with adverse characteristics had an elevated risk for ASD. Transmission of ASD risk through maternal and paternal factors should be considered in future research on ASD aetiology. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 7, 2021 Category: Epidemiology Source Type: research

Protein foods from animal sources, incident cardiovascular disease and all-cause mortality: a substitution analysis
ConclusionsNuts, whole grains, legumes and fish appeared to be healthier protein sources than eggs, processed meat, unprocessed red meat and poultry for preventing incident CVD and premature death. The magnitude of lower risk for incident CVD and all-cause mortality was driven by amount and number of animal protein foods substituted. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 7, 2021 Category: Epidemiology Source Type: research

A comprehensive evaluation of methods for Mendelian randomization using realistic simulations and an analysis of 38 biomarkers for risk of type 2 diabetes
ConclusionThe relative performance of different MR methods depends heavily on the sample sizes of the underlying GWAS, the proportion of valid instruments and the validity of the InSIDE assumption. Down-sampling analysis can be used in large GWAS for the possible detection of bias in the MR methods. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 4, 2021 Category: Epidemiology Source Type: research

Cohort Profile: The Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) and the follow-up studies
CRISPScardiovascular diseasesdiabetes mellitusmetabolic syndromecohort profileChinese (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - January 4, 2021 Category: Epidemiology Source Type: research