Seroprevalence of SARS-CoV-2 antibodies in over 6000 healthcare workers in Spain

AbstractBackgroundSpain has one of the highest incidences of coronavirus disease 2019 (COVID-19) worldwide, so Spanish health care workers (HCW) are at high risk of exposure. Our objective was to determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody seroprevalence amongst HCW and factors associated with seropositivity.MethodsA cross-sectional study evaluating 6190 workers (97.8% of the total workforce of a healthcare-system of 17 hospitals across four regions in Spain) was carried out between April and June 2020, by measuring immunoglobulin G (IgG)-SARS-CoV-2 antibody titres and related clinical data. Exposure risk was categorized as high (clinical environment; prolonged/direct contact with patients), moderate (clinical environment; non-intense/no patient contact) and low (non-clinical environment).ResultsA total of 6038 employees (mean age 43.8 years; 71% female) were included in the final analysis. A total of 662 (11.0%) were seropositive for IgG against SARS-CoV-2 (39.4% asymptomatic). Adding available PCR-testing, 713 (11.8%) employees showed evidence of previous SARS-CoV-2 infection. However, before antibody testing, 482 of them (67%) had no previous diagnosis of SARS-CoV-2-infection. Seroprevalence was higher in high- and moderate-risk exposure (12.1 and 11.4%, respectively) compared with low-grade risk subjects (7.2%), and in Madrid (13.8%) compared with Barcelona (7.6%) and Coru ña (2.0%). High-risk [odds ratio (OR): 2.06; 95% confiden...
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research

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In this study, we consider an alternative design where we recruit among all individuals, symptomatic and asymptomatic, being tested for the virus in addition to population controls. We define a regression parameter related to a prospective risk factor analysis and investigate its identifiability under the two study designs. We review the difference between the prospective risk factor parameter and the parameter targeted in the typical TND where only symptomatic and tested people are recruited. Using missing data directed acyclic graphs, we provide conditions and required data collection under which identifiability of the p...
Source: Epidemiology - Category: Epidemiology Tags: Infectious Diseases Source Type: research
MONDAY, Aug. 2, 2021 -- Breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among fully vaccinated health care workers are mainly mild or asymptomatic, according to a study published online July 28 in the New England...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Getting the kids ready to go back to school each fall is stressful enough in a normal year, never mind in the midst of a pandemic. Between the more transmissible Delta coronavirus variant, rising cases across the country and new masking guidance from the U.S. Centers for Disease Control and Prevention (CDC), there’s a lot for parents to navigate as they plan for schools to reopen this August and September. On the whole, experts seem to agree it’s time to get kids back into their classrooms. Remote learning set many children—especially students of color—back academically, cut them off from essential ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Minerva Anestesiol. 2021 Aug 2. doi: 10.23736/S0375-9393.21.15977-2. Online ahead of print.NO ABSTRACTPMID:34337926 | DOI:10.23736/S0375-9393.21.15977-2
Source: Minerva Anestesiologica - Category: Anesthesiology Authors: Source Type: research
Med Sci Monit. 2021 Aug 2;27:e934171. doi: 10.12659/MSM.934171.ABSTRACTInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) commonly presents with pneumonia. However, COVID-19 is now recognized to involve multiple organ systems with varying severity and duration. In July 2021, the findings from a retrospective population study from the National COVID Cohort Collaborative (N3C) Consortium were published that included analysis by machine learning methods of 174,568 adults with SARS-CoV-2 infection from 34 medical centers in the US. The study stratified pa...
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
Jpn J Infect Dis. 2021 Jul 30. doi: 10.7883/yoken.JJID.2021.091. Online ahead of print.ABSTRACTCoronavirus disease 2019 is diagnosed based on the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasopharyngeal swabs or saliva using real-time quantitative polymerase chain reaction. Nasopharyngeal swabs should be collected by medical professionals wearing full personal protective equipment (PPE), while saliva can be collected by patients themselves without PPE. However, collecting saliva is difficult for people unable to follow instructions, including infants or unconscious patients. Owing to ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
CONCLUSIONS: The tracheal diameter may increase in proportion to the severity of inflammation, indicating or accompanying a poor prognosis. Patients with extensive involvement should be monitored closely for the development of tracheal stenosis.PMID:34337732 | DOI:10.26355/eurrev_202107_26397
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
This article summarizes the possible therapeutic potential and benefits of using montelukast, a cysteinyl leukotriene 1 (CysLT1) receptor antagonist, to control COVID-19 pathophysiology. Montelukast has shown anti-inflammatory effects, reduced cytokine production, improvement in post-infection cough production and other lung complications.Key Messages: Recent reports clearly indicate a distinct role of CysLT-regulated cytokines and immunological signaling in COVID-19. Thus, montelukast may have a clinical potential to control lung pathology during COVID-19.Pharmacology
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research
ABSTRACTThe COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin-like Dps from hyperthermophilicSulfolobus islandicus, covalently coupled with SARS-CoV-2 antigens via the SpyCatcher system, forms stable multivalent dodecameric vaccine nanoparticles that remain intact even after lyophilisation. Immunisation experiments in mice demonstrated that the SARS-CoV-2 receptor binding domain (RBD) coupled to Dps (RBD-S-Dps) elicited a higher antibody titre and an enhanced neutralising antibody response compared to monomeric RBD. A single immunisation with RB...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH LETTER Source Type: research
Conclusion: The AN procedure, which was used within 72 h after the admission of patients with COVID-19, was safe and could be successfully implemented during the first two waves of COVID-19 in France. Nevertheless, AN did not significantly improve the outcome of the patients in our small preliminary study. It is pertinent to explore further to validate AN as the non-invasive mass vagal stimulation solution for the forthcoming pandemics.Clinical Trial Registration: [https://clinicaltrials.gov/], identifier [NCT04341415].
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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