Lysosomal BK channels facilitate silica-induced inflammation in macrophages
CONCLUSION: Taken together, these results demonstrate that inhibiting lysosomal BK channel activity with PAX effectively reduced silica-induced cell death and IL-1β release. Blocking cytosolic K+ entry into the lysosome prevented LMP through the decrease of lysosomal acidification and proteolytic function and increase in lysosomal cholesterol.PMID:38261520 | DOI:10.1080/08958378.2024.2305112 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - January 23, 2024 Category: Respiratory Medicine Authors: Rebekah L Kendall Andrij Holian Source Type: research
Establishing short-term occupational exposure limits (STELs) for sensory irritants using predictive and < em > in silico < /em > respiratory rate depression (RD < sub > 50 < /sub > ) models
Inhal Toxicol. 2024 Jan 22:1-13. doi: 10.1080/08958378.2023.2299867. Online ahead of print.ABSTRACTSensory irritation is a health endpoint that serves as the critical effect basis for many occupational exposure limits (OELs). Schaper 1993 described a significant relationship with high correlation between the measured exposure concentration producing a 50% respiratory rate decrease (RD50) in a standard rodent assay and the American Conference of Governmental Industrial Hygienists (ACGIH®) Threshold Limit Values (TLVs®) as time-weighted averages (TWAs) for airborne chemical irritants. The results demonstrated the potential...
Source: Inhalation Toxicology - January 22, 2024 Category: Respiratory Medicine Authors: Anthony J Russell Melissa Vincent Amanda N Buerger Scott Dotson Jason Lotter Andrew Maier Source Type: research
Long-term health complications of chemical weapon exposure: a study on Halabja chemical attack survivors (Iraqi Kurds)
CONCLUSION: In this study comparing CW survivors with a local control population, a single, high-dose exposure to CWs was associated with significant increases in chronic respiratory and cardiac conditions, in addition to high rates of ADL impairment. Similar studies are needed in other, more recent CW survivor cohorts.PMID:38190328 | DOI:10.1080/08958378.2024.2301985 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - January 8, 2024 Category: Respiratory Medicine Authors: Belal A Muhammad Salih A Hama Karzan A M Hawrami Salar H Karim Gasha S Ahmed Hawbash M Rahim Source Type: research
Analysis of abnormal expression of signaling pathways in PQ-induced acute lung injury in SD rats based on RNA-seq technology
Conclusion: The signaling pathways enriched with these differentially expressed genes are summarized, and the important mechanisms mediated through these pathways in acute lung injury during paraquat poisoning are outlined to identify important targets for AH2QDS treatment of acute lung injury due to paraquat exposure, information that will be used to support a subsequent in-depth study on the mechanism of PQ action.PMID:38175690 | DOI:10.1080/08958378.2023.2300373 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - January 4, 2024 Category: Respiratory Medicine Authors: Nan Li Yue Huang Yang Yi Jin Qian Qi Li Shuang-Qin Xu Hang-Fei Wang Xin-Xin Wu Ji-Chao Peng Li-Hua Li Jin-Jian Yao Xiao-Ran Liu Source Type: research
Impact of black soot emissions on public health in Niger Delta, Nigeria: understanding the severity of the problem
Inhal Toxicol. 2023 Dec 25:1-13. doi: 10.1080/08958378.2023.2297698. Online ahead of print.ABSTRACTRivers State, Niger Delta, Nigeria often referred to as the 'treasure bed of the nation' is the seat of crude oil production activities with the accompanying environmental degradation. The severity of the environmental pollution and contaminated air quality took a new turn for the worse in November 2016, when the residents of Port Harcourt city, Rivers State, a major oil producing State experienced for the first time, aerosol deposition of plumes of black soot. This systematic review paper is aimed at quantifying the severity...
Source: Inhalation Toxicology - December 25, 2023 Category: Respiratory Medicine Authors: Osazuwa Clinton Ekhator Fortune Chiemelie Orish Ernest O Nnadi Daprim Samuel Ogaji Success Isuman Orish Ebere Orisakwe Source Type: research
