Crystalline silica-induced pulmonary inflammation and autoimmunity in mature adult NZBW/f1 mice: age-related sensitivity and impact of omega-3 fatty acid intervention
CONCLUSION: These results highlight life-stage significance in this preclinical lupus model and underscore omega-3 fatty acids' therapeutic potential against toxicant-triggered autoimmune responses.PMID:38477125 | DOI:10.1080/08958378.2024.2318378 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 13, 2024 Category: Respiratory Medicine Authors: Lauren K Heine Tasha Scarlett James G Wagner Ryan P Lewandowski Abby D Benninghoff Ashleigh N Tindle Anna E Skedel Jack R Harkema James J Pestka Source Type: research
Biological effects of diesel exhaust inhalation. III cardiovascular function
CONCLUSIONS: Based on the results of this study, we suggest that exposure to DE generated by a Tier 2 compliant diesel engine generates acute effects on biomarkers indicative of cardiovascular dysfunction. Recovery occurs quickly with most measures of vascular/cardiovascular function returning to baseline levels by 7d following exposure.PMID:38466202 | DOI:10.1080/08958378.2024.2327364 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 11, 2024 Category: Respiratory Medicine Authors: Kristine Krajnak Hong Kan Janet A Thompson Walter McKinney Stacey Waugh Tim South Dru Burns Ryan Lebouf Jared Cumpston Theresa Boots Jeffrey S Fedan Source Type: research
Short-term hyperoxia induced mitochondrial respiratory chain complexes dysfunction and oxidative stress in lung of rats
CONCLUSION: In conclusion, we have experimentally demonstrated that short-term exposure to high FIO2 can cause oxidative stress in the lung.PMID:38449063 | DOI:10.1080/08958378.2024.2322497 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 6, 2024 Category: Respiratory Medicine Authors: Leonardo Tenfen Richard Simon Machado Khiany Mathias Natalia Piacentini Larissa Joaquim Sandra Bonfante Lucineia Gainski Danielski Nicole Alessandra Engel Mariella Reinol da Silva Gislaine Tezza Rezin Rafaella Willig de Quadros Fernanda Frederico Gava Fab Source Type: research
Lipid mediators of inhalation exposure-induced pulmonary toxicity and inflammation
Inhal Toxicol. 2024 Feb 29:1-18. doi: 10.1080/08958378.2024.2318389. Online ahead of print.ABSTRACTMany inhalation exposures induce pulmonary inflammation contributing to disease progression. Inflammatory processes are actively regulated via mediators including bioactive lipids. Bioactive lipids are potent signaling molecules involved in both pro-inflammatory and resolution processes through receptor interactions. The formation and clearance of lipid signaling mediators are controlled by multiple metabolic enzymes. An imbalance of these lipids can result in exacerbated and sustained inflammatory processes which may result ...
Source: Inhalation Toxicology - February 29, 2024 Category: Respiratory Medicine Authors: Arjun Pitchai Kimberly Buhman Jonathan H Shannahan Source Type: research
Notoginsenoside R1 restrains the proliferation and migration of airway smooth muscle cells isolated from rats with chronic obstructive pulmonary disease
CONCLUSIONS: NGR1 can restrain the proliferation and migration of CSE-induced ASMCs, indicating that NGR1 may be a therapeutic candidate for treating COPD.PMID:38411938 | DOI:10.1080/08958378.2024.2319708 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - February 27, 2024 Category: Respiratory Medicine Authors: Xiaoyong Li Kai Chen Xuefei Shi Shunli Dong Yi Chen Bin Wang Source Type: research
