Natural mineral fibers: conducting inhalation toxicology studies - part A: Libby Amphibole aerosol generation and characterization method development
CONCLUSIONS: Characterization of the prototype system demonstrated feasibility of generating LA 2007 fiber aerosols appropriate for in vivo inhalation toxicity studies. The methods developed in this study are suitable to apply to a multiple-carousel exposure system for a rat inhalation toxicity testing using LA 2007.PMID:37339371 | DOI:10.1080/08958378.2023.2220737 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies-part B: development of a nose-only exposure system for repeat-exposure < em > in vivo < /em > study of Libby amphibole aerosol
CONCLUSION: The exposure system developed is ready for use in conducting nose-only inhalation toxicity studies of LA 2007 in rats. The exposure system is anticipated to have applicability for the inhalation toxicity evaluation of other natural mineral fibers of concern.PMID:37339372 | DOI:10.1080/08958378.2023.2220735 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies - part A: Libby Amphibole aerosol generation and characterization method development
CONCLUSIONS: Characterization of the prototype system demonstrated feasibility of generating LA 2007 fiber aerosols appropriate for in vivo inhalation toxicity studies. The methods developed in this study are suitable to apply to a multiple-carousel exposure system for a rat inhalation toxicity testing using LA 2007.PMID:37339371 | DOI:10.1080/08958378.2023.2220737 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies-part B: development of a nose-only exposure system for repeat-exposure < em > in vivo < /em > study of Libby amphibole aerosol
CONCLUSION: The exposure system developed is ready for use in conducting nose-only inhalation toxicity studies of LA 2007 in rats. The exposure system is anticipated to have applicability for the inhalation toxicity evaluation of other natural mineral fibers of concern.PMID:37339372 | DOI:10.1080/08958378.2023.2220735 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies - part A: Libby Amphibole aerosol generation and characterization method development
CONCLUSIONS: Characterization of the prototype system demonstrated feasibility of generating LA 2007 fiber aerosols appropriate for in vivo inhalation toxicity studies. The methods developed in this study are suitable to apply to a multiple-carousel exposure system for a rat inhalation toxicity testing using LA 2007.PMID:37339371 | DOI:10.1080/08958378.2023.2220737 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies-part B: development of a nose-only exposure system for repeat-exposure < em > in vivo < /em > study of Libby amphibole aerosol
CONCLUSION: The exposure system developed is ready for use in conducting nose-only inhalation toxicity studies of LA 2007 in rats. The exposure system is anticipated to have applicability for the inhalation toxicity evaluation of other natural mineral fibers of concern.PMID:37339372 | DOI:10.1080/08958378.2023.2220735 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies - part A: Libby Amphibole aerosol generation and characterization method development
CONCLUSIONS: Characterization of the prototype system demonstrated feasibility of generating LA 2007 fiber aerosols appropriate for in vivo inhalation toxicity studies. The methods developed in this study are suitable to apply to a multiple-carousel exposure system for a rat inhalation toxicity testing using LA 2007.PMID:37339371 | DOI:10.1080/08958378.2023.2220737 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Natural mineral fibers: conducting inhalation toxicology studies-part B: development of a nose-only exposure system for repeat-exposure < em > in vivo < /em > study of Libby amphibole aerosol
CONCLUSION: The exposure system developed is ready for use in conducting nose-only inhalation toxicity studies of LA 2007 in rats. The exposure system is anticipated to have applicability for the inhalation toxicity evaluation of other natural mineral fibers of concern.PMID:37339372 | DOI:10.1080/08958378.2023.2220735 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 20, 2023 Category: Respiratory Medicine Authors: Anbo Wang Amit Gupta Michael D Grimm David T Pressburger Barney R Sparrow Jamie S Richey John R Shaw Karen E Elsass Georgia K Roberts Pei-Li Yao Matthew D Stout Benjamin J Ellis Robyn L Ray Source Type: research
Biological effects of inhaled crude oil vapor. III. Pulmonary inflammation, cytotoxicity, and gene expression profile
CONCLUSION: Taken together, the results from this exposure paradigm, including concentration, duration, and exposure chamber parameters, did not indicate significant and toxicologically relevant changes in markers of injury, oxidant generation, inflammation, and gene expression profile in the lung.PMID:37330949 | DOI:10.1080/08958378.2023.2224394 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 18, 2023 Category: Respiratory Medicine Authors: Tina M Sager Pius Joseph Christina M Umbright Ann F Hubbs Mark Barger Michael L Kashon Jeffrey S Fedan Jenny R Roberts Source Type: research
Perturbations in indices of oxidative stress, oxidative DNA damage and lung function in chronic exposure to wood dust in Southern Nigeria
CONCLUSION: The association of exposure to wood dust with elevated indices of inflammation, OS, lipid peroxidation, oxidative DNA damage, and reduction in antioxidants and peak expiratory flow rate; and the concomitant increase in oxidative DNA damage and inflammation with increasing duration of exposure suggest that these indices may be useful in predicting woodworkers at risk of development of chronic lung conditions.PMID:37326599 | DOI:10.1080/08958378.2023.2224388 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 16, 2023 Category: Respiratory Medicine Authors: Augusta Chinyere Nsonwu-Anyanwu Raymond Ekong Eworo Unyime Aniekpon Fabian Uduak Luke Caroline Chinenyenwa Thomas Olivia Kamsi Muoka Unwanaabasi Okon Ufot Chinyere Adanna Opara Usoro Source Type: research
Toxicological and epidemiological approaches to carcinogenic potency modeling for mixed mineral fiber exposure: the case of fibrous balangeroite and chrysotile
CONCLUSION: The presence of different types of mineral fibers in aerosolized materials even in small proportions can explain observed cancer risks.PMID:37220304 | DOI:10.1080/08958378.2023.2213720 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 23, 2023 Category: Respiratory Medicine Authors: Andrey A Korchevskiy Ann G Wylie Source Type: research
