Lysosomal BK channels facilitate silica-induced inflammation in macrophages

CONCLUSION: Taken together, these results demonstrate that inhibiting lysosomal BK channel activity with PAX effectively reduced silica-induced cell death and IL-1β release. Blocking cytosolic K+ entry into the lysosome prevented LMP through the decrease of lysosomal acidification and proteolytic function and increase in lysosomal cholesterol.PMID:38261520 | DOI:10.1080/08958378.2024.2305112
Source: Inhalation Toxicology - Category: Respiratory Medicine Authors: Source Type: research