Rates of Lower Respiratory Tract Illness in US Adults by Age and Comorbidity Profile
ConclusionsIncidence of LRTI, including that due to RSV, especially for events requiring acute inpatient care, is markedly higher among older adults and adults of all ages with CMC or IC. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - January 1, 2024 Category: Infectious Diseases Source Type: research
Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis
ConclusionResults suggest that different types of varicella-associated complications could be frequent, impacting quality of life, and healthcare resource utilisation and budgets. These findings are crucial to raise awareness of the health and economic burden of varicella disease. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 19, 2023 Category: Infectious Diseases Source Type: research
Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein
ConclusionThe calculation of the probability for bacterial infection using MxA and CRP may efficiently discriminate between viral and bacterial respiratory infections. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 19, 2023 Category: Infectious Diseases Source Type: research
Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis
ConclusionResults suggest that different types of varicella-associated complications could be frequent, impacting quality of life, and healthcare resource utilisation and budgets. These findings are crucial to raise awareness of the health and economic burden of varicella disease. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 19, 2023 Category: Infectious Diseases Source Type: research
Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein
ConclusionThe calculation of the probability for bacterial infection using MxA and CRP may efficiently discriminate between viral and bacterial respiratory infections. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 19, 2023 Category: Infectious Diseases Source Type: research
A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol
ConclusionThe OPTIMISE trial is the first randomized controlled trial specifically designed to assess the duration of antimicrobial therapy in patients with severe infections by MDR-GNB.Trial RegistrationClinicalTrials.gov, NCT05210387. Registered on 27 January 2022. Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (OPTIMISE). (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 16, 2023 Category: Infectious Diseases Source Type: research
Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies
ConclusionsTwo doses of 20 µg and 40 µg ReCOV are safe and immunogenic against SARS-CoV-2 prototype. The cross-neutralizing activities against Omicron variants support ReCOV advance to late-stage clinical trials.Trial RegistrationPhase I study, clinicaltrials.gov NCT04818801; phase II study, clinicaltrials.gov NCT05084989. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 16, 2023 Category: Infectious Diseases Source Type: research
A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol
ConclusionThe OPTIMISE trial is the first randomized controlled trial specifically designed to assess the duration of antimicrobial therapy in patients with severe infections by MDR-GNB.Trial RegistrationClinicalTrials.gov, NCT05210387. Registered on 27 January 2022. Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (OPTIMISE). (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 16, 2023 Category: Infectious Diseases Source Type: research
Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies
ConclusionsTwo doses of 20 µg and 40 µg ReCOV are safe and immunogenic against SARS-CoV-2 prototype. The cross-neutralizing activities against Omicron variants support ReCOV advance to late-stage clinical trials.Trial RegistrationPhase I study, clinicaltrials.gov NCT04818801; phase II study, clinicaltrials.gov NCT05084989. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 16, 2023 Category: Infectious Diseases Source Type: research
Correction: Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000 –2012)
(Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 15, 2023 Category: Infectious Diseases Source Type: research
Assessing the Underestimation of Adult Pertussis Disease in Five Latin American Countries
ConclusionThis analysis indicates that the number of pertussis cases in adults aged ≥ 50 years in five Latin American countries is approximately 100 times higher than the number captured in surveillance data. These results could support decision-making in the diagnosis, management, and prevention of pertussis disease in adults. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 14, 2023 Category: Infectious Diseases Source Type: research
Burden of Herpes Zoster in Individuals with Immunocompromised Conditions and Autoimmune Diseases in the Republic of Korea: A Nationwide Population-Based Database Study
ConclusionIndividuals with IC/AID have a substantial disease and economic burden from HZ in ROK, highlighting the need for appropriate HZ prevention measures in the IC/AID population.Plain Language Summary (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 12, 2023 Category: Infectious Diseases Source Type: research
Meningococcal Disease in the Post –COVID-19 Era: A Time to Prepare
AbstractThe global invasive meningococcal disease (IMD) landscape changed considerably during the COVID-19 pandemic, as evidenced by decreased incidence rates due to COVID-19 mitigation measures, such as limited social contact, physical distancing, mask wearing, and hand washing. Vaccination rates were also lower during the pandemic relative to pre-pandemic levels. Although policymakers may have shifted their focus away from IMD vaccination programs to COVID-19 vaccination programs, strong arguments support implementation and prioritization of IMD vaccination programs; IMD cases have increased in some countries and IMD rat...
Source: Infectious Diseases and Therapy - December 4, 2023 Category: Infectious Diseases Source Type: research
