Household Influenza Transmission and Healthcare Resource Utilization Among Patients Treated with Baloxavir vs Oseltamivir: A United States Outpatient Prospective Survey
ConclusionsThe findings from this real-world study suggest that antiviral treatment of influenza with baloxavir may decrease household transmission and reduce healthcare resource utilization compared with oseltamivir. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 14, 2024 Category: Infectious Diseases Source Type: research
Effect of Infusion Set Replacement Intervals on Central Line-Associated Bloodstream Infection in the Intensive Care Unit: Study Protocol of the INSPIRATION Study
ConclusionThis is the first randomized controlled trial to investigate the effects of infusion set replacement at 24-h and 96-h intervals on CLABSI in ICU patients.Trial RegistrationClinicalTrials.gov identifier, NCT05359601. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 14, 2024 Category: Infectious Diseases Source Type: research
Epidemiology of Reportable Bacterial Infectious Diseases in Saudi Arabia
ConclusionsThe future perspective of this research is to enhance disease surveillance reporting by including different variables, such as the source of infection, travel history, hospitalization, and mortality rates. The aim is to improve the sensitivity and specificity of surveillance data and focus on the mortality associated with bacterial pathogens to identify the most significant threats and set a public health priority. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 10, 2024 Category: Infectious Diseases Source Type: research
Longitudinal Molecular and Serological Evidence of SARS-CoV-2 Infections and Vaccination Status: Community-Based Surveillance Study (CONTACT)
ConclusionsThis study expands on prior studies assessing COVID-19 immunity and IgG seroconversion by including both RT-PCR and serologic testing and longitudinal follow-up of study participants. We observed decreased infection rates over the 9 month follow-up period as well as a decline in IgG persistency after 6 months. The findings from this community-based study regarding vaccinate rates, infection rates by PCR, and IgG persistency over time can help improve our understanding of COVID-19 immunity, occupational risks related to SARS- CoV-2 exposure, and the kinetics of long-term IgG seroconversion, which is important ...
Source: Infectious Diseases and Therapy - March 10, 2024 Category: Infectious Diseases Source Type: research
Epidemiology of Reportable Bacterial Infectious Diseases in Saudi Arabia
ConclusionsThe future perspective of this research is to enhance disease surveillance reporting by including different variables, such as the source of infection, travel history, hospitalization, and mortality rates. The aim is to improve the sensitivity and specificity of surveillance data and focus on the mortality associated with bacterial pathogens to identify the most significant threats and set a public health priority. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 10, 2024 Category: Infectious Diseases Source Type: research
Longitudinal Molecular and Serological Evidence of SARS-CoV-2 Infections and Vaccination Status: Community-Based Surveillance Study (CONTACT)
ConclusionsThis study expands on prior studies assessing COVID-19 immunity and IgG seroconversion by including both RT-PCR and serologic testing and longitudinal follow-up of study participants. We observed decreased infection rates over the 9 month follow-up period as well as a decline in IgG persistency after 6 months. The findings from this community-based study regarding vaccinate rates, infection rates by PCR, and IgG persistency over time can help improve our understanding of COVID-19 immunity, occupational risks related to SARS- CoV-2 exposure, and the kinetics of long-term IgG seroconversion, which is important ...
Source: Infectious Diseases and Therapy - March 10, 2024 Category: Infectious Diseases Source Type: research
Effect of Renal Impairment on Pharmacokinetics and Safety of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor
ConclusionEnsitrelvir was well tolerated by participants with renal impairment. There was no clinically meaningful increase on exposure to ensitrelvir in participants with renal impairment, indicating that no dose adjustment would be required due to renal function. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 9, 2024 Category: Infectious Diseases Source Type: research
Clinical Characteristics of Uncomplicated Acute Pyelonephritis Caused by Escherichia coli and Klebsiella pneumoniae
ConclusionsMale, underlying diseases, and prior antibiotic use was more associated withK. pneumoniae. Further study will be needed that microbiome of each situation and the related with the distribution of the strains. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 9, 2024 Category: Infectious Diseases Source Type: research
Effect of Renal Impairment on Pharmacokinetics and Safety of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor
ConclusionEnsitrelvir was well tolerated by participants with renal impairment. There was no clinically meaningful increase on exposure to ensitrelvir in participants with renal impairment, indicating that no dose adjustment would be required due to renal function. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 9, 2024 Category: Infectious Diseases Source Type: research
Clinical Characteristics of Uncomplicated Acute Pyelonephritis Caused by Escherichia coli and Klebsiella pneumoniae
ConclusionsMale, underlying diseases, and prior antibiotic use was more associated withK. pneumoniae. Further study will be needed that microbiome of each situation and the related with the distribution of the strains. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 9, 2024 Category: Infectious Diseases Source Type: research
Living During COVID-19 While Immunocompromised: A Patient and Physician Perspective from France
This article is co-authored by a kidney transplant recipient and her nephrologist. By sharing her personal experience of the coronavirus disease 2019 (COVID-19) pandemic, the patient illustrates the concerns of immunocompromised patients during this unprecedented health crisis. She describes the difficulties encountered at work, the omnipresent protective measures, and the need for appropriate information. The nephrologist, who follows a cohort of over 1700 kidney transplant recipients, recounts the medical team ’s struggle to protect their vulnerable patients against severe acute respiratory syndrome coronavirus 2 (SAR...
Source: Infectious Diseases and Therapy - March 8, 2024 Category: Infectious Diseases Source Type: research
Amoebic Liver Abscess: Potential Application of New Diagnostic Techniques for an Old Pathogen
We report a case of an amoebic liver abscess promptly diagnosed by FilmArray gastrointestinal panel performed on liver drainage fluid. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 8, 2024 Category: Infectious Diseases Source Type: research
Living During COVID-19 While Immunocompromised: A Patient and Physician Perspective from France
This article is co-authored by a kidney transplant recipient and her nephrologist. By sharing her personal experience of the coronavirus disease 2019 (COVID-19) pandemic, the patient illustrates the concerns of immunocompromised patients during this unprecedented health crisis. She describes the difficulties encountered at work, the omnipresent protective measures, and the need for appropriate information. The nephrologist, who follows a cohort of over 1700 kidney transplant recipients, recounts the medical team ’s struggle to protect their vulnerable patients against severe acute respiratory syndrome coronavirus 2 (SAR...
Source: Infectious Diseases and Therapy - March 8, 2024 Category: Infectious Diseases Source Type: research
The Impact of the COVID-19 Pandemic on the Incidence of Herpes Zoster: A Narrative Literature Review
AbstractCoronavirus disease 2019 (COVID-19) has had a broad impact on health services and health outcomes. During the pandemic, there were numerous reports of herpes zoster (HZ) in people with COVID-19 and in COVID-19 vaccine recipients. The aim of this review is to elucidate the global effects of the COVID-19 pandemic on HZ. It is postulated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces an immunosuppressive state that favours varicella zoster virus (VZV) reactivation. Three large cohort studies (a multinational study and studies from the USA and Spain) that excluded individuals vacci...
Source: Infectious Diseases and Therapy - March 5, 2024 Category: Infectious Diseases Source Type: research
