Comparison of Risk Stratification Approaches to Identify Patients with Clostridioides difficile Infection at Risk for Multidrug-Resistant Organism Gut Microbiota Colonization
ConclusionA simplified approach using prior healthcare exposure and receipt of prior antibiotics known to increase CDI risk identified patients at risk for MDRO gut microbiome colonization as effectively as individual patient/antibiotic risk modeling. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 12, 2023 Category: Infectious Diseases Source Type: research
Improved Diagnostics in Bacterial Neonatal Meningitis Using a Next-Generation Sequencing Platform
ConclusionAddition of 16S rRNA sequencing to conventional culturing greatly improved the identification of the aetiology of bacterial meningitis compared to culturing of CSF samples alone. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 12, 2023 Category: Infectious Diseases Source Type: research
Comparison of Risk Stratification Approaches to Identify Patients with Clostridioides difficile Infection at Risk for Multidrug-Resistant Organism Gut Microbiota Colonization
ConclusionA simplified approach using prior healthcare exposure and receipt of prior antibiotics known to increase CDI risk identified patients at risk for MDRO gut microbiome colonization as effectively as individual patient/antibiotic risk modeling. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 12, 2023 Category: Infectious Diseases Source Type: research
Patient Biochemistry and Treatment Need in Chronic Hepatitis B Virus Infection Across Three Continents: Retrospective Cross-Sectional Cohort Studies
ConclusionThis large real-world dataset demonstrates that chronic hepatitis B infection remains a global health concern; despite the availability of effective suppressive therapy, a considerable proportion of predominantly adult patients apparently indicated for treatment are currently untreated, including many patients with fibrosis/cirrhosis. Causes of disparity in treatment status warrant further investigation. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 11, 2023 Category: Infectious Diseases Source Type: research
Clinical and Economic Value of Reducing Antimicrobial Resistance in the Management of Hospital-Acquired Infections with Limited Treatment Options in Greece
ConclusionThis study shows the substantial clinical and economic burden AMR represents to the Greek healthcare system and the value that can be achieved by effectively reducing AMR levels. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 6, 2023 Category: Infectious Diseases Source Type: research
Protective Effect of BCG and Neutrophil-to-Lymphocyte Ratio on Latent Tuberculosis in End Stage Renal Disease
ConclusionThe prevalence of LTBI was as high as 18.8% in patients with end-stage kidney disease or kidney transplant. BCG vaccination and high NLR might have protective effects against LTBI in patients with renal failure or transplant. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 6, 2023 Category: Infectious Diseases Source Type: research
Meningococcal B Immunisation in Adults and Potential Broader Immunisation Strategies: A Narrative Review
AbstractRecombinant vaccines against invasive meningococcal disease due toNeisseria meningitidis serogroup B (MenB) have shown substantial impact in reducing MenB disease in targeted populations. 4CMenB targets four keyN. meningitidis protein antigens; human factor H binding protein (fHbp), Neisserial heparin binding antigen (NHBA),Neisseria adhesin A (NadA) and the porin A protein (PorA P1.4), with one or more of these expressed by most pathogenic MenB strains, while MenB-FHbp targets two distinct fHbp variants. While many countries recommend MenB immunisation in adults considered at high risk due to underlying medical co...
Source: Infectious Diseases and Therapy - July 6, 2023 Category: Infectious Diseases Source Type: research
Clinical and Economic Value of Reducing Antimicrobial Resistance in the Management of Hospital-Acquired Infections with Limited Treatment Options in Greece
ConclusionThis study shows the substantial clinical and economic burden AMR represents to the Greek healthcare system and the value that can be achieved by effectively reducing AMR levels. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 6, 2023 Category: Infectious Diseases Source Type: research
Protective Effect of BCG and Neutrophil-to-Lymphocyte Ratio on Latent Tuberculosis in End Stage Renal Disease
ConclusionThe prevalence of LTBI was as high as 18.8% in patients with end-stage kidney disease or kidney transplant. BCG vaccination and high NLR might have protective effects against LTBI in patients with renal failure or transplant. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 6, 2023 Category: Infectious Diseases Source Type: research
Patient Experiences with Clostridioides difficile Infection and Its Treatment: A Systematic Literature Review
ConclusionCDI and rCDI are debilitating conditions affecting physical, psychological, social, and professional functioning of patients ’ HRQoL, even long after the event has occurred. The results of this SLR suggest that CDI is a devastating condition in need of better prevention strategies, improved psychological support, and treatments that address the microbiome disruption to break the cycle of recurrence. Additional safe and effective therapies are needed to address this unmet medical need. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - July 3, 2023 Category: Infectious Diseases Source Type: research
Narrative Review of the Epidemiology of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia in Gulf Cooperation Council Countries
AbstractHospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are the most common healthcare-associated infections, with rates varying between countries. Antimicrobial resistance (AMR) among common HAP/VAP pathogens has been reported, and multidrug resistance (MDR) is of further concern across Middle Eastern countries. This narrative review summarizes the incidence and pathogens associated with HAP/VAP in hospitals across Gulf Cooperation Council (GCC) countries. A PubMed literature search was limited to available data on HAP or VAP in patients of any age published within the past 10 years. Reviews,...
Source: Infectious Diseases and Therapy - June 30, 2023 Category: Infectious Diseases Source Type: research
