Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis
ConclusionsBUN is suitable for independently predicting short-term mortality in patients with IE. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Range of Clinical Manifestations Caused by Invasive Meningococcal Disease Due to Serogroup W: A Systematic Review
ConclusionsClinicians need to be aware of the nonspecific symptoms and signs of IMD, as well as of the atypical manifestations in regions where MenW is known to circulate to ensure timely diagnoses and treatment. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Outpatient Treatment with AZD7442 (Tixagevimab/Cilgavimab) Prevented COVID-19 Hospitalizations over 6 Months and Reduced Symptom Progression in the TACKLE Randomized Trial
ConclusionsAZD7442 was well tolerated and reduced hospitalization and mortality through 6 months, and symptom burden through 29 days, in outpatients with mild-to-moderate COVID-19.Clinical Trial RegistrationClinicaltrials.gov, NCT04723394. (https://beta.clinicaltrials.gov/study/NCT04723394).Graphical Abstract (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Week 240 Efficacy and Safety of Fostemsavir Plus Optimized Background Therapy in Heavily Treatment-Experienced Adults with HIV-1
ConclusionThrough ~5 years, fostemsavir + OBT demonstrated durable virologic and immunologic responses with no new safety concerns between Weeks 96 and 240, supporting this regimen as a key therapeutic option for HTE people with multidrug-resistant HIV-1.Trial registrationClinicalTrials.gov, NCT02362503. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
A Pharmacovigilance Analysis of Daptomycin Use Based on CLSI Susceptible Dose-Dependent Category
ConclusionHigh-dose daptomycin was not associated with increased laboratory abnormalities or adverse drug reactions compared to standard-dose daptomycin. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Efficacy and Safety of Gepotidacin as Treatment of Uncomplicated Urogenital Gonorrhea (EAGLE-1): Design of a Randomized, Comparator-Controlled, Phase 3 Study
This study will help characterize the risk –benefit profile of gepotidacin for treating uncomplicated urogenital gonorrhea. Gepotidacin is an important potential treatment for gonorrhea to help address the urgent unmet need of multidrug resistance and the increasingly limited number of oral treatment options.Trial RegistrationClinicalTrials.gov identifier, NCT04010539. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis
ConclusionsBUN is suitable for independently predicting short-term mortality in patients with IE. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Range of Clinical Manifestations Caused by Invasive Meningococcal Disease Due to Serogroup W: A Systematic Review
ConclusionsClinicians need to be aware of the nonspecific symptoms and signs of IMD, as well as of the atypical manifestations in regions where MenW is known to circulate to ensure timely diagnoses and treatment. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 26, 2023 Category: Infectious Diseases Source Type: research
Screening for Asymptomatic Clostridioides difficile Carriage Among Hospitalized Patients: A Narrative Review
We present a literature review of studies evaluating a strategy of screening and isolation of asymptomatic carriers in hospital settings. Asymptomatic detection ofC. difficile is reported in ~ 10–20% of admitted patients. Risk factors for carriage include recent hospitalization, previous antibiotics, older age, lower functional capacity, immunosuppression, and others. AsymptomaticC. difficile carriers of toxigenic strains are at higher risk for progression to CDI. They are also shedders ofC. difficile spores and may contribute to the persistence and transmission of this bacterium. Screening for asymptomatic carriers a...
Source: Infectious Diseases and Therapy - September 13, 2023 Category: Infectious Diseases Source Type: research
Misoprostol-Induced Fever and Unnecessary Antibiotic Prescribing: A Retrospective Study
ConclusionThis study contributes to the understanding of misoprostol-induced fever in the context of medical abortion. Further research is needed to explore strategies for reducing unnecessary antibiotic use in this population. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 13, 2023 Category: Infectious Diseases Source Type: research
Clusters of SARS-CoV-2 Infection Across Six Schools for Students with Intellectual and Developmental Disabilities
ConclusionThe Omicron variant led to an increase in cluster-based transmission, and staying up to date with vaccination guidelines was crucial in limiting transmission.Clinical Trial RegistrationPrior to enrollment, this study was registered at ClinicalTrials.gov on September 25, 2020 (identifier NCT04565509; titled “Supporting the Health and Well-being of Children with Intellectual and Developmental Disability During COVID-19 Pandemic”). (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 13, 2023 Category: Infectious Diseases Source Type: research
Screening for Asymptomatic Clostridioides difficile Carriage Among Hospitalized Patients: A Narrative Review
We present a literature review of studies evaluating a strategy of screening and isolation of asymptomatic carriers in hospital settings. Asymptomatic detection ofC. difficile is reported in ~ 10–20% of admitted patients. Risk factors for carriage include recent hospitalization, previous antibiotics, older age, lower functional capacity, immunosuppression, and others. AsymptomaticC. difficile carriers of toxigenic strains are at higher risk for progression to CDI. They are also shedders ofC. difficile spores and may contribute to the persistence and transmission of this bacterium. Screening for asymptomatic carriers a...
Source: Infectious Diseases and Therapy - September 13, 2023 Category: Infectious Diseases Source Type: research
Misoprostol-Induced Fever and Unnecessary Antibiotic Prescribing: A Retrospective Study
ConclusionThis study contributes to the understanding of misoprostol-induced fever in the context of medical abortion. Further research is needed to explore strategies for reducing unnecessary antibiotic use in this population. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 13, 2023 Category: Infectious Diseases Source Type: research
Clusters of SARS-CoV-2 Infection Across Six Schools for Students with Intellectual and Developmental Disabilities
ConclusionThe Omicron variant led to an increase in cluster-based transmission, and staying up to date with vaccination guidelines was crucial in limiting transmission.Clinical Trial RegistrationPrior to enrollment, this study was registered at ClinicalTrials.gov on September 25, 2020 (identifier NCT04565509; titled “Supporting the Health and Well-being of Children with Intellectual and Developmental Disability During COVID-19 Pandemic”). (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 13, 2023 Category: Infectious Diseases Source Type: research
Safety and Immunogenicity of the BNT162b2 Vaccine Coadministered with Seasonal Inactivated Influenza Vaccine in Adults
ConclusionsBNT162b2 coadministered with SIIV elicited immune responses that were noninferior to those elicited by BNT162b2 alone and SIIV alone, and BNT162b2 had an acceptable safety profile when coadministered with SIIV. The results of this study support the coadministration of BNT162b2 and SIIV in adults.Trial RegistrationClinicalTrials.gov registration: NCT05310084. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 12, 2023 Category: Infectious Diseases Source Type: research
