Identification of distinct LRC- and Fc receptor complex-like chromosomal regions in fish supports that teleost leukocyte immune-type receptors are distant relatives of mammalian Fc receptor-like molecules
AbstractLeukocyte immune-type receptors (LITRs) are a large family of immunoregulatory receptor-types originally identified in the channel catfish (Ictalurus punctatus (Ip)LITRs). Phylogenetic analyses of LITRs show that they share distant evolutionary relationships with important mammalian immunoregulatory receptors belonging to the Fc receptors family and the leukocyte receptor complex (LRC), but their syntenic relationships with these immunoglobulin superfamily members have not been investigated. To further examine the possible evolutionary connections between teleost LITRs and various mammalian immunoregulatory recepto...
Source: Immunogenetics - January 7, 2021 Category: Genetics & Stem Cells Source Type: research
A systematic review of microRNAs as potential biomarkers for diagnosis and prognosis of gastric cancer
AbstractGastric cancer (GC) is the third leading cause of global cancer morbidity and mortality. One of the significant challenges in GC treatment is that most GC patients are diagnosed with advanced-stage disease due to the lack of suitable biomarkers. Recent studies have shown that microRNAs (miRNAs) can acts as a potential biomarker in GC diagnosis and prognosis. I performed a systematic review of published miRNA studies in GC, which includes the miRNA expression profiles between GC tissues and normal tissues and also miRNA studies to evaluate their potential value in the diagnosis and prognosis of GC. Among the studies...
Source: Immunogenetics - January 5, 2021 Category: Genetics & Stem Cells Source Type: research
Immunogenetics special issue 2021: fish immunology
(Source: Immunogenetics)
Source: Immunogenetics - January 4, 2021 Category: Genetics & Stem Cells Source Type: research
Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis
This study suggests that theRUNX3 locus may associate with PBC in Han Chinese. (Source: Immunogenetics)
Source: Immunogenetics - December 7, 2020 Category: Genetics & Stem Cells Source Type: research
Evidence for the loss of plasminogen receptor KT gene in chicken
AbstractThe loss of conserved genes has the potential to alter phenotypes drastically. Screening of vertebrate genomes for lineage-specific gene loss events has identified numerous natural knockouts associated with specific phenotypes. We provide evidence for the loss of a multi-exonic plasminogen receptor KT (PLGRKT) protein-encoding gene located on the Z chromosome in chicken. Exons 1 and 2 are entirely missing; remnants of exon 3 and a mostly intact exon 4 are identified in an assembly gap-free region in chicken with conserved synteny across species and verified using transcriptome and genome sequencing.PLGRKT gene disr...
Source: Immunogenetics - November 28, 2020 Category: Genetics & Stem Cells Source Type: research
