Correction to: Differences in pyroptosis of recent thymic emigrants CD4 + T Lymphocytes in ART‑treated HIV‑positive patients are influenced by sex
A correction to this paper has been published:https://doi.org/10.1007/s00251-021-01207-8 (Source: Immunogenetics)
Source: Immunogenetics - August 1, 2021 Category: Genetics & Stem Cells Source Type: research
Analyzing the characteristics of immune cell infiltration in lung adenocarcinoma via bioinformatics to predict the effect of immunotherapy
This study shows that the ICI score may be a potent prognostic biomarker a nd predictor of therapy with immune checkpoint inhibitors. (Source: Immunogenetics)
Source: Immunogenetics - July 24, 2021 Category: Genetics & Stem Cells Source Type: research
Computational identification and characterization of antigenic properties of Rv3899c of Mycobacterium tuberculosis and its interaction with human leukocyte antigen (HLA)
In this study, Rv3899c of H37Rv emerges as a potential vaccine candidate on its evaluation by several bioinformatics tools. It is a non-toxic, secretory protein with an ‘immunoglobulin-like’ fold which does not show similarity with a human protein. Through BlastP and MEME sui te analysis, we found Rv3899c homologs in several mycobacterial species and its antigenic score (0.54) to compare well with the known immunogens such as ESAT-6 (0.56) and Rv1860 (0.52). Structural examination of Rv3899c predicted ten antigenic peptides, an accessibility profile of the antigenic dete rminants constituting B cell epitope-rich region...
Source: Immunogenetics - July 6, 2021 Category: Genetics & Stem Cells Source Type: research
Polymorphism and varying selection within the MHC class I of four Anas species
AbstractDucks (Anatidae) are often vectors for the spread of pathogens because of their long-distance migrations. These migrations also expose ducks to a wide variety of pathogens in their wintering and breeding grounds, and, as a consequence, we might expect strong selection on their immune genes. Here, we studied exons 2 and 3 of the MHC class I in four species ofAnas ducks (A. platyrhynchos,A. poecilorhyncha,A. formosa, andA. querquedula) using Illumina-sequencing. Both exons 2 and 3 code for the peptide-binding region of class I molecules; however, most previous studies of birds have only focused on exon 3. Here, we fo...
Source: Immunogenetics - June 30, 2021 Category: Genetics & Stem Cells Source Type: research
High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing
AbstractOf the 12 full-length feline leukocyte antigen class I (FLAI) loci, 3 are presumed to be classical:FLAI-E,FLAI-H, andFLAI-K. As diversity is a class Ia hallmark, multi-allelism is an important surrogate supporting a classical designation, in the absence of direct demonstration of T-cell restriction. Conversely, limited polymorphism at an expressed locus suggests regulation of immune effectors with invariant receptors, and non-classical status.FLAI-A,FLAI-J,FLAI-L, andFLAI-O are putative class Ib genes in cats. For both classes, identifying prevalent variants across outbred populations can illuminate specific genoty...
Source: Immunogenetics - June 27, 2021 Category: Genetics & Stem Cells Source Type: research
Evidence for the loss and recovery of SLAMF9 during human evolution: implications on Dollo ’s law
AbstractSignaling lymphocyte activation molecule family member 9 (SLAMF9) is a cell surface protein of the CD2/SLAM family of leukocyte surface receptors. It is conserved throughout mammals and has roles in the initiation of inflammatory responses and regulation of plasmacytoid dendritic cell function. Through comparison of reference sequences encoding SLAMF9 in human, mouse, and primate sequences, we have determined that the SLAMF9 gene underwent successive mutation events, resulting in the loss of the protein and subsequent recovery of a less stable version. The mutations included a single base pair deletion in the secon...
Source: Immunogenetics - June 1, 2021 Category: Genetics & Stem Cells Source Type: research
Rs-10889677 variant in interleukin-23 receptor may contribute to creating an inflammatory milieu more susceptible to bladder tumourigenesis: report and meta-analysis
AbstractBladder cancer (BLC) is a recurrent high-risk malignancy typified by an inherent localised chronic inflammation. IL-23-receptor (IL-23R), as a positive regulator in the priming of T helper-17 cells, is regarded a principal coordinator of inflammation-propelled neoplasia. In this article, we indented firstly to scrutinise the influence of rs10889677 “A/C” SNP located in IL-23R-gene on BLC development and progression among Egyptians. Findings revealed that the rs10889677“C” allele was significantly associated with the increased BLC risk and its higher frequencies were plainly noticeable in high-grade and inva...
Source: Immunogenetics - June 1, 2021 Category: Genetics & Stem Cells Source Type: research
Annotation of immune genes in the extinct thylacine (Thylacinus cynocephalus)
AbstractAdvances in genome sequencing technology have enabled genomes of extinct species to be sequenced. However, given the fragmented nature of these genome assemblies, it is not clear whether it is possible to comprehensively annotate highly variable and repetitive genes such as those involved in immunity. As such, immune genes have only been investigated in a handful of extinct genomes, mainly in human lineages. In 2018 the genome of the thylacine (Thylacinus cynocephalus), a carnivorous marsupial from Tasmania that went extinct in 1936, was sequenced. Here we attempt to characterise the immune repertoire of the thylac...
Source: Immunogenetics - June 1, 2021 Category: Genetics & Stem Cells Source Type: research
KIR2DL4 genetic diversity in a Brazilian population sample: implications for transcription regulation and protein diversity in samples with different ancestry backgrounds
AbstractKIR2DL4 is an important immune modulator expressed in natural killer cells; HLA-G is its main ligand. We have characterized theKIR2DL4 genetic diversity by considering the promoter, all exons, and all introns in a highly admixed Brazilian population sample and by using massively parallel sequencing. We introduce a molecular method to amplify and to sequence the completeKIR2DL4 gene. To avoid the mapping bias and genotype errors commonly observed in gene families, we have developed and validated a bioinformatic pipeline designed to minimize these errors and applied it to survey the variability of 220 individuals fro...
Source: Immunogenetics - June 1, 2021 Category: Genetics & Stem Cells Source Type: research
Variation and expression of HLA-DPB1 gene in HBV infection
AbstractHepatitis B virus (HBV) affects approximately 68 million people in China, and 10 –15% of adults infected with HBV develop chronic hepatitis B, liver cirrhosis, liver failure or hepatocellular carcinoma (HCC). HLA-DPB1 gene polymorphism and expression have been shown to be associated with HBV infection susceptibility and spontaneous clearance. The aim of this study is to evalua te the role of HLA-DPB1 gene polymorphism in HBV infection. HLA-DPB1 and rs9277535 polymorphisms were investigated in 259 patients with HBV infection and 442 healthy controls (HCs) using sequence-based typing. The mRNA of HLA-DPB1 was measu...
Source: Immunogenetics - June 1, 2021 Category: Genetics & Stem Cells Source Type: research
Erik Thorsby (1938 –2021)
(Source: Immunogenetics)
Source: Immunogenetics - June 1, 2021 Category: Genetics & Stem Cells Source Type: research
