Identification of potential predictive biomarkers and biological pathways and the correction with immune infiltration in the activation of Crohn ’s disease
In this study, we analyzed differentially expressed genes (DEGs) and molecular pathways through between active and inactive CD patients. In addition, the abundance of 22 immune cell types were assessed by using the CIBERSORT. The hub DEGs were screened out by the CytoHubba in Cytoscape, followed by the least absolute shrinkage and selection operator (LASSO) regression. Finally, the clinical predictive model was constructed by binary logistic regression model. The diagnostic efficacy was tested by re ceiver operating characteristic (ROC) curve and verified in independent datasets. The results showed that there were 137 DEGs...
Source: Immunogenetics - July 21, 2022 Category: Genetics & Stem Cells Source Type: research
Correction to: Multiple Alr genes exhibit allorecognition-associated variation in the colonial cnidarian Hydractinia
(Source: Immunogenetics)
Source: Immunogenetics - July 12, 2022 Category: Genetics & Stem Cells Source Type: research
Introducing our new Immunogenetics co-editor: Professor Andrew Brooks
(Source: Immunogenetics)
Source: Immunogenetics - July 5, 2022 Category: Genetics & Stem Cells Source Type: research
Multiple Alr genes exhibit allorecognition-associated variation in the colonial cnidarian Hydractinia
AbstractThe genetics of allorecognition has been studied extensively in inbred lines ofHydractinia symbiolongicarpus, in which genetic control is attributed mainly to the highly polymorphic lociallorecognition 1 (Alr1) andallorecognition 2 (Alr2), located within the Allorecognition Complex (ARC). While allelic variation atAlr1 andAlr2 can predict the phenotypes in inbred lines, these two loci do not entirely predict the allorecognition phenotypes in wild-type colonies and their progeny, suggesting the presence of additional uncharacterized genes that are involved in the regulation of allorecognition in this species. Compar...
Source: Immunogenetics - June 27, 2022 Category: Genetics & Stem Cells Source Type: research
Correction to: Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish
(Source: Immunogenetics)
Source: Immunogenetics - June 6, 2022 Category: Genetics & Stem Cells Source Type: research
Masanori Kasahara: Long-standing Immunogenetics co-editor steps down
(Source: Immunogenetics)
Source: Immunogenetics - May 27, 2022 Category: Genetics & Stem Cells Source Type: research
IgG subclasses in New World Monkeys: an issue for debate?
AbstractImmunoglobulin G (IgG) is an essential antibody in adaptive immunity; a differential expansion of the gene encoding the Fc region (IGHG) of this antibody has been observed in mammals. Like humans, animal biomedical models, such as mice and macaques, have four functional genes encoding 4 IgG subclasses; however, the data for New World monkeys (NWM) seems contentious. Some publications argue for the existence of a single-copy gene for IgG Fc; however, a recent paper has suggested the presence of IgG subclasses in some NWM species. Here, we evaluated the genetic distances and phylogenetic relationships in NWM to asses...
Source: Immunogenetics - May 26, 2022 Category: Genetics & Stem Cells Source Type: research
Natural LILRB1 D1-D2 variants show frequency differences in populations and bind to HLA class I with various avidities
AbstractLeukocyte immunoglobulin-like receptor B1 (LILRB1) is widely expressed on various immune cells and the engagement of LILRB1 to HLA class I and pathogen-derived proteins can modulate the immune response. In the current study, 108 LILRB1 alleles were identified by screening the LILRB1 locus from the 1000 Genomes Phase 3 database. Forty-six alleles that occurred in three or more individuals encode 28 LILRB1 allotypes, and the inferred LILRB1 allotypes were then grouped into 9 LILRB1 D1-D2 variants for further analysis. We found that variants 1, 2, and 3 represent the three most frequent LILRB1 D1-D2 variants and the...
Source: Immunogenetics - May 13, 2022 Category: Genetics & Stem Cells Source Type: research
