Tumor necrosis factor- α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation
AbstractTumor necrosis factor-alpha (TNF- α) is a potent pro-inflammatory factor that plays an important role in establishing a complicated connection between inflammation and cancer. TNF-α promotes tumor proliferation, migration, invasion, and angiogenesis according to numerous studies. Studies have shown the significant role of STAT3, a downstream transcription factor of another important inflammatory cytokine, IL-6 in the development and progression of different tumors especially colorectal cancer. In the present study, we investigated whether TNF-α has a role in proliferation and apoptosis of colorectal cancer cells...
Source: Immunogenetics - March 18, 2023 Category: Genetics & Stem Cells Source Type: research
The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides
AbstractThe physiological expression of HLA-G is mainly observed in the placenta, playing an essential role in maternal –fetal tolerance. Among theHLA-G mRNA alternative transcripts, the one lacking 92 bases at theHLA-G 3 ′ untranslated region (3′UTR), the 92bDel transcript, is more stable, is associated with increased HLA-G soluble levels, and was observed in individuals presenting a 14 bp insertion (14 bp+) at the 3 ′UTR. We investigated the presence of the 92bDel transcript in placenta samples, correlating its expression levels with theHLA-G polymorphisms at the 3 ′UTR. The 14 bp+ allele correlates with the...
Source: Immunogenetics - March 7, 2023 Category: Genetics & Stem Cells Source Type: research
Correction to: The immunogenetics of COVID-19
(Source: Immunogenetics)
Source: Immunogenetics - February 23, 2023 Category: Genetics & Stem Cells Source Type: research
Expression analysis of Carassius auratus-leukocyte-immune-type receptors (CaLITRs) during goldfish kidney macrophage development and in activated kidney leukocyte cultures
AbstractCarassius auratus leukocyte immune-type receptors (CaLITRs) were recently discovered immunoregulatory receptors in goldfish that have diverse immunoglobulin-like (Ig-like) ectodomains and intracellular signaling motifs. Genomic analysis shows that CaLITR-types are also located as distinct gene clusters across multiple goldfish chromosomes. For example, CaLITR1 (unplaced) is a functionally ambiguous receptor having two Ig-like domains, a transmembrane domain (TM), and a short cytoplasmic tail (CYT) devoid of any recognizable signaling motifs. CaLITR2 (Chr47) is a putative inhibitory receptor containing four Ig-like ...
Source: Immunogenetics - February 18, 2023 Category: Genetics & Stem Cells Source Type: research
Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct
(Source: Immunogenetics)
Source: Immunogenetics - February 13, 2023 Category: Genetics & Stem Cells Source Type: research
Role of T cells in severe COVID-19 disease, protection, and long term immunity
AbstractInfection with SARS-CoV-2 causes wide range of disease severities from asymptomatic to life-threatening disease. Understanding the contribution of immunological traits in immunity against SARS-CoV-2 and in protection against severe COVID-19 could result in effective measures to prevent development of severe disease. While the role of cytokines and antibodies has been thoroughly studied, this is not the case for T cells. In this review, the association between T cells and COVID-19 disease severity and protection upon reexposure is discussed. While infiltration of overactivated cytotoxic T cells might be harmful in t...
Source: Immunogenetics - February 8, 2023 Category: Genetics & Stem Cells Source Type: research
Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
AbstractKiller-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction. (Source: Immunogenetics)
Source: Immunogenetics - January 31, 2023 Category: Genetics & Stem Cells Source Type: research
Evolution of SARS-CoV-2-specific CD4+ T cell epitopes
In this study, we investigated the resistance/susceptibility of T helper cell responses that are necessary for generating efficient long-lasting antibody immunity, in several VOCs. By predicting T helper cell epitopes on the spike protein for most common HLA-DRB1 alleles worldwide, we found that although most of high frequency HLA-DRB1 alleles have several potential T helper cell epitopes, few alleles like HLA-DRB1 13:01 and 11:01 are not predicted to have any significant T helper cell responses after vaccination. Usi ng these predictions, a population based on realistic human leukocyte antigen-II (HLA-II) frequencies we...
Source: Immunogenetics - January 31, 2023 Category: Genetics & Stem Cells Source Type: research
