Antibody-Mediated Neutralization of SARS-CoV-2
Neutralizing antibodies play a critical role to protect from SARS-CoV-2 infection and can be effectively used to prevent and treat COVID-19. In this review, Klein and colleagues summarize key findings on the development and mechanisms of SARS-CoV-2 neutralizing antibodies and discuss advances in the clinical application of antibody-mediated antiviral strategies. (Source: Immunity)
Source: Immunity - May 12, 2022 Category: Allergy & Immunology Authors: Henning Gruell, Kanika Vanshylla, Timm Weber, Christopher O. Barnes, Christoph Kreer, Florian Klein Tags: Review Source Type: research
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases
The efficacies of COVID-19 vaccines have decreased over time and as new variants have emerged. Bhattacharya discusses basic plasma cell biology, the features of vaccines that influence the duration of antibody production, and possible paths to lasting immunity against COVID-19. (Source: Immunity)
Source: Immunity - May 9, 2022 Category: Allergy & Immunology Authors: Deepta Bhattacharya Tags: Perspective Source Type: research
Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche
CSF-1 is an important maintenance factor for monocytes, but the functionally important CSF-1 producing bone marrow niche cells are unknown. Emoto et al. reveal that Ly6C− monocytes are maintained by CSF-1 producing sinusoidal endothelial cells, whereas Ly6Chi monocytes require combined production of CSF-1 by endothelium and Lepr+ perivascular stromal cells. (Source: Immunity)
Source: Immunity - May 3, 2022 Category: Allergy & Immunology Authors: Takuo Emoto, Jessie Lu, Tharini Sivasubramaniyam, Hassaan Maan, Aniqa B. Khan, Amina A. Abow, Stephanie A. Schroer, Sharon J. Hyduk, Marwan G. Althagafi, Trevor D. McKee, Fred Fu, Shiva Shabro, Antigona Ulndreaj, Felix Chiu, Elvira Paneda, Shaun Pacheco, Tags: Article Source Type: research
Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
Pathogens manipulate the host immune system to induce the wrong effector response known as immune deviation; however, the mechanisms of immune deviation are poorly understood. Agaronyan et al. demonstrate that Pseudomonas aeruginosa induces host mucin production to promote tissue remodeling and, as a by-product, allergic immune response. (Source: Immunity)
Source: Immunity - April 27, 2022 Category: Allergy & Immunology Authors: Karen Agaronyan, Lokesh Sharma, Bharat Vaidyanathan, Keith Glenn, Shuang Yu, Charles Annicelli, Talia D. Wiggen, Mitchell R. Penningroth, Ryan C. Hunter, Charles S. Dela Cruz, Ruslan Medzhitov Tags: Article Source Type: research
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Tuberculosis granulomas exhibit independent trajectories even within a single individual: some granulomas permit high bacterial growth, whereas others successfully resolve. Gideon et al. leveraged longitudinal PET-CT, bacterial burden assays, and scRNA-seq in cynomolgus macaques to define dynamic cellular phenotypes and circuits underlying granuloma persistence and immune control. Uncovered cell states and interactions may represent targets for host-directed therapies and vacc ines. (Source: Immunity)
Source: Immunity - April 27, 2022 Category: Allergy & Immunology Authors: Hannah P. Gideon, Travis K. Hughes, Constantine N. Tzouanas, Marc H. Wadsworth, Ang Andy Tu, Todd M. Gierahn, Joshua M. Peters, Forrest F. Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L. Grant, Kievershen Nargan, Jia Yao Phuah, H. Jacob Borish, Paulin Tags: Article Source Type: research
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments
Our understanding of persistent HIV tissue reservoirs is constrained by our limited ability to visualize the cellular components of these viral reservoirs. Jiang et al. develop a robust method that combines nucleic acid and protein imaging, termed PANINI, and use it to uncover the orchestrated immune events of retroviral lymphoid tissue reservoirs. (Source: Immunity)
Source: Immunity - April 20, 2022 Category: Allergy & Immunology Authors: Sizun Jiang, Chi Ngai Chan, Xavier Rovira-Clav é, Han Chen, Yunhao Bai, Bokai Zhu, Erin McCaffrey, Noah F. Greenwald, Candace Liu, Graham L. Barlow, Jason L. Weirather, John Paul Oliveria, Tsuguhisa Nakayama, Ivan T. Lee, Matthias S. Matter, Anne E. Carl Tags: Resource Source Type: research
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
The signals that drive cognitive impairment in Alzheimer ’s disease (AD) remain elusive. Type I interferon (IFN-I) activation is implicated in neurodegenerative conditions, including AD. Using cellular fate-mapping, receptor blockade, and conditional deletion models, Roy et al. demonstrate that IFN-I signaling in different brain cell types, including m icroglia and neural cells, critically affects synapses and causes cognitive impairment in an AD model. (Source: Immunity)
Source: Immunity - April 19, 2022 Category: Allergy & Immunology Authors: Ethan R. Roy, Gabriel Chiu, Sanming Li, Nicholas E. Propson, Rupa Kanchi, Baiping Wang, Cristian Coarfa, Hui Zheng, Wei Cao Tags: Article Source Type: research
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
LAG-3 is a potent inhibitory co-receptor; yet, its functional ligand remains elusive. By generating mice with LAG-3 mutants that are defective in binding to either of its potential ligands, Maruhashi et al. show that stable peptide-MHC class II, but not fibrinogen-like protein (FGL1), serves as its functional ligand to suppress T cells in autoimmunity and anti-cancer immunity. (Source: Immunity)
Source: Immunity - April 11, 2022 Category: Allergy & Immunology Authors: Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Kenji Shimizu, Takeo K. Maeda, Jun Ikubo, Harunori Yoshikawa, Katsumi Maenaka, Naozumi Ishimaru, Hidetaka Kosako, Tatsuya Takemoto, Taku Okazaki Tags: Article Source Type: research
Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant
Whether memory B cells (MBCs) elicited by SARS-CoV-2 mRNA vaccines can recognize the Omicron variant remains unclear. Sokal et al. show that compared to other variants of concern, Omicron evaded recognition and neutralization by a larger proportion of MBC-derived antibodies elicited after infection and/or vaccination. Nonetheless, omicron-neutralizing MBC clones could be found in the repertoire of all individuals analysed. (Source: Immunity)
Source: Immunity - April 6, 2022 Category: Allergy & Immunology Authors: Aur élien Sokal, Matteo Broketa, Giovanna Barba-Spaeth, Annalisa Meola, Ignacio Fernández, Slim Fourati, Imane Azzaoui, Andrea de La Selle, Alexis Vandenberghe, Anais Roeser, Magali Bouvier-Alias, Etienne Crickx, Laetitia Languille, Marc Michel, Bertran Tags: Article Source Type: research
Analysis Of Memory B Cells Identifies Conserved Neutralizing Epitopes On The N-Terminal Domain Of Variant SARS-Cov-2 Spike Proteins
Most neutralizing antibodies to SARS-CoV-2 NTD characterized to date bind a single supersite, but these antibodies were obtained by methods that were not NTD-specific. Wang et al. analyzed SARS-CoV-2 NTD-specific memory B cell responses in a longitudinal cohort of infected individuals, some of whom were vaccinated. Structural analysis revealed neutralizing epitopes conserved among variants of concern outside the NTD supersite. (Source: Immunity)
Source: Immunity - April 6, 2022 Category: Allergy & Immunology Authors: Zijun Wang, Frauke Muecksch, Alice Cho, Christian Gaebler, Hans-Heinrich Hoffmann, Victor Ramos, Shuai Zong, Melissa Cipolla, Briana Johnson, Fabian Schmidt, Justin DaSilva, Eva Bednarski, Tarek Ben Tanfous, Raphael Raspe, Kaihui Yao, Yu E. Lee, Teresia C Tags: Article Source Type: research
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
STAT6 is requisite for anti-helminth immunity, but it is presently unclear how STAT6 activity is fine-tuned to orchestrate “alarmin” cytokine responses. Zhao et al. reveal that O-GlcNAc modification allows STAT6 to drive the differentiation of IL-25-producing tuft cells and facilitate the unconventional IL-33 secretion via GSDMC membrane pores. (Source: Immunity)
Source: Immunity - April 5, 2022 Category: Allergy & Immunology Authors: Ming Zhao, Kaiqun Ren, Xiwen Xiong, Yue Xin, Yujie Zou, Jason C. Maynard, Angela Kim, Alexander P. Battist, Navya Koneripalli, Yusu Wang, Qianyue Chen, Ruyue Xin, Chenyan Yang, Rong Huang, Jiahui Yu, Zan Huang, Zengdi Zhang, Haiguang Wang, Daoyuan Wang, Y Tags: Article Source Type: research
Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation
Transcription factor T-bet is critically involved in type 1 immune responses. Fang et al. report that type 1 innate and adaptive lymphocytes utilize distinct cis-regulatory elements at the Tbx21 locus for T-bet induction during their development, differentiation, and activation. (Source: Immunity)
Source: Immunity - April 4, 2022 Category: Allergy & Immunology Authors: Difeng Fang, Kairong Cui, Yaqiang Cao, Mingzhu Zheng, Takeshi Kawabe, Gangqing Hu, Jaspal S. Khillan, Dan Li, Chao Zhong, Dragana Jankovic, Alan Sher, Keji Zhao, Jinfang Zhu Tags: Article Source Type: research
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
D ähling et al. establish the role of cDCs for immunotherapy and find that cDC1s are required to mediate viral control. cDC1s provide a niche to maintain the precursors of exhausted T (Tpex) cell population and prevent their overactivation and subsequent immunopathology. These findings reveal the im portance of cDC1s in maintaining Tpex cells to balance viral control, exhaustion, and immunopathology. (Source: Immunity)
Source: Immunity - April 1, 2022 Category: Allergy & Immunology Authors: Sabrina D ähling, Ana Maria Mansilla, Konrad Knöpper, Anika Grafen, Daniel T. Utzschneider, Milas Ugur, Paul G. Whitney, Annabell Bachem, Panagiota Arampatzi, Fabian Imdahl, Tsuneyasu Kaisho, Dietmar Zehn, Frederick Klauschen, Natalio Garbi, Axel Kallie Tags: Article Source Type: research
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
The mechanisms through which microsatellite-stable colorectal cancer inhibits anti-tumor immunity and resists immune checkpoint blockade are incompletely understood. Peuker et al. describe a microbiota-dependent pathway of crosstalk between myeloid cells, T cells, and tumor cells that inhibits CD8+ T cell-dependent anti-tumor immunity through the co-inhibitory proteins B7H3 and B7H4 and that is amenable to therapeutic targeting. (Source: Immunity)
Source: Immunity - March 31, 2022 Category: Allergy & Immunology Authors: Kenneth Peuker, Anne Strigli, Daniele V.F. Tauriello, Alexander Hendricks, Witigo von Sch önfels, Greta Burmeister, Mario Brosch, Alexander Herrmann, Sandra Krüger, Jessica Nitsche, Lea Južnić, Marc Marius Geissler, Andreas Hiergeist, André Gessner, Tags: Article Source Type: research
Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors
LN stromal cells are crucial organizers of lymphoid compartments and regulators of adaptive immune responses, but their origin remains still elusive. Lenti et al. reveal that different stromal cell subsets originate from embryonic Hoxb6+ mesodermal progenitors and show that stromal diversity is acquired early during LN development. (Source: Immunity)
Source: Immunity - March 30, 2022 Category: Allergy & Immunology Authors: Elisa Lenti, Luca Genovese, Silvia Bianchessi, Aurora Maurizio, Simona Baghai Sain, Alessia di Lillo, Greta Mattavelli, Itamar Harel, Francesca Bernassola, Thomas Hehlgans, Klaus Pfeffer, Mariacristina Crosti, Sergio Abrignani, Sylvia M. Evans, Giovanni S Tags: Article Source Type: research
