Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

The signals that drive cognitive impairment in Alzheimer ’s disease (AD) remain elusive. Type I interferon (IFN-I) activation is implicated in neurodegenerative conditions, including AD. Using cellular fate-mapping, receptor blockade, and conditional deletion models, Roy et al. demonstrate that IFN-I signaling in different brain cell types, including m icroglia and neural cells, critically affects synapses and causes cognitive impairment in an AD model.

Source: Immunity - April 19, 2022 Category: Allergy & Immunology Authors: Ethan R. Roy, Gabriel Chiu, Sanming Li, Nicholas E. Propson, Rupa Kanchi, Baiping Wang, Cristian Coarfa, Hui Zheng, Wei Cao Tags: Article Source Type: research