Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation

Transcription factor T-bet is critically involved in type 1 immune responses. Fang et  al. report that type 1 innate and adaptive lymphocytes utilize distinct cis-regulatory elements at the Tbx21 locus for T-bet induction during their development, differentiation, and activation.

Source: Immunity - April 4, 2022 Category: Allergy & Immunology Authors: Difeng Fang, Kairong Cui, Yaqiang Cao, Mingzhu Zheng, Takeshi Kawabe, Gangqing Hu, Jaspal S. Khillan, Dan Li, Chao Zhong, Dragana Jankovic, Alan Sher, Keji Zhao, Jinfang Zhu Tags: Article Source Type: research