SARS-CoV-2 infections in children: understanding diverse outcomes
Brodin summarizes the current understanding of immune responses to SARS-CoV-2 infections in children and the possible explanations for the overall milder COVID-19 disease in young vs. older individuals. To explain the combined observations to date, Brodin proposes an energy allocation perspective to explain mild disease, viral dynamics and MIS-C in children and young people. (Source: Immunity)
Source: Immunity - January 19, 2022 Category: Allergy & Immunology Authors: Petter Brodin Tags: Review Source Type: research
Are NKT cells a useful predictor of COVID-19 severity?
(Source: Immunity)
Source: Immunity - January 18, 2022 Category: Allergy & Immunology Authors: Hui-Fern Koay, Nicholas A. Gherardin, Thi HO. Nguyen, Wuji Zhang, Jennifer R. Habel, Rebecca Seneviratna, Fiona James, Natasha E. Holmes, Olivia C. Smibert, Claire L. Gordon, Jason A. Trubiano, Katherine Kedzierska, Dale I. Godfrey Tags: Letter Source Type: research
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia
The pathways controlling platelet-neutrophils interactions remain unclear. Poli et al. demonstrate that the transcription factor NFAT regulates the hemostatic and inflammatory activities of platelets. NFAT inhibition in activated platelets increases dense granule release, platelet aggregation, and interactions with neutrophils. NFAT inhibition in platelets in vivo initiates a d etrimental feedback loop that enhances disseminated coagulation and NETosis and aggravates bacterial septicemia. (Source: Immunity)
Source: Immunity - January 6, 2022 Category: Allergy & Immunology Authors: Valentina Poli, Marco Di Gioia, Martha Sola-Visner, Francesca Granucci, Andrew L. Frelinger, Alan D. Michelson, Ivan Zanoni Tags: Article Source Type: research
mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern
SARS-CoV-2 mRNA vaccines provide cross-variant protection against COVID-19. Whether this is mediated strictly via neutralization or is linked to effector functions that may limit, rather than block, transmission remains unknown. Kaplonek et al. show that mRNA-1273-vaccination-induced antibodies preserve Fc effector responses across variants of concern, whereas antibodies induced following natural infection show compromised interactions with Fc-receptors. (Source: Immunity)
Source: Immunity - January 5, 2022 Category: Allergy & Immunology Authors: Paulina Kaplonek, Stephanie Fischinger, Deniz Cizmeci, Yannic C. Bartsch, Jaewon Kang, John S. Burke, Sally A. Shin, Diana Dayal, Patrick Martin, Colin Mann, Fatima Amanat, Boris Julg, Eric J. Nilles, Elon R. Musk, Anil S. Menon, Florian Krammer, Erica Ol Tags: Article Source Type: research
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization
Broadly neutralizing antibodies (bNAbs) can protect from HCV infection, but little is known about their development and specific characteristics. Weber, Potthoff et al. isolated potent HCV bNAbs from individuals with exceptional HCV antibody responses and determined the genetic requirements for high neutralizing activity. Based on these data, they computationally designed a de novo antibody that efficiently neutralized multiple HCV genotypes. (Source: Immunity)
Source: Immunity - January 5, 2022 Category: Allergy & Immunology Authors: Timm Weber, Julian Potthoff, Sven Bizu, Maurice Labuhn, Leona Dold, Till Schoofs, Marcel Horning, Meryem S. Ercanoglu, Christoph Kreer, Lutz Gieselmann, Kanika Vanshylla, Bettina Langhans, Hanna Janicki, Luisa J. Str öh, Elena Knops, Dirk Nierhoff, Ulric Tags: Article Source Type: research
