Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia
The pathways controlling platelet-neutrophils interactions remain unclear. Poli et al. demonstrate that the transcription factor NFAT regulates the hemostatic and inflammatory activities of platelets. NFAT inhibition in activated platelets increases dense granule release, platelet aggregation, and interactions with neutrophils. NFAT inhibition in platelets in vivo initiates a d etrimental feedback loop that enhances disseminated coagulation and NETosis and aggravates bacterial septicemia.
Source: Immunity - Category: Allergy & Immunology Authors: Valentina Poli, Marco Di Gioia, Martha Sola-Visner, Francesca Granucci, Andrew L. Frelinger, Alan D. Michelson, Ivan Zanoni Tags: Article Source Type: research
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