Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia

The pathways controlling platelet-neutrophils interactions remain unclear. Poli et  al. demonstrate that the transcription factor NFAT regulates the hemostatic and inflammatory activities of platelets. NFAT inhibition in activated platelets increases dense granule release, platelet aggregation, and interactions with neutrophils. NFAT inhibition in platelets in vivo initiates a d etrimental feedback loop that enhances disseminated coagulation and NETosis and aggravates bacterial septicemia.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research