Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche

CSF-1 is an important maintenance factor for monocytes, but the functionally important CSF-1 producing bone marrow niche cells are unknown. Emoto et  al. reveal that Ly6C− monocytes are maintained by CSF-1 producing sinusoidal endothelial cells, whereas Ly6Chi monocytes require combined production of CSF-1 by endothelium and Lepr+ perivascular stromal cells.

Source: Immunity - May 3, 2022 Category: Allergy & Immunology Authors: Takuo Emoto, Jessie Lu, Tharini Sivasubramaniyam, Hassaan Maan, Aniqa B. Khan, Amina A. Abow, Stephanie A. Schroer, Sharon J. Hyduk, Marwan G. Althagafi, Trevor D. McKee, Fred Fu, Shiva Shabro, Antigona Ulndreaj, Felix Chiu, Elvira Paneda, Shaun Pacheco, Tags: Article Source Type: research