Binding of LAG-3 to stable peptide-MHC class II limits T  cell function and suppresses autoimmunity and anti-cancer immunity

LAG-3 is a potent inhibitory co-receptor; yet, its functional ligand remains elusive. By generating mice with LAG-3 mutants that are defective in binding to either of its potential ligands, Maruhashi et  al. show that stable peptide-MHC class II, but not fibrinogen-like protein (FGL1), serves as its functional ligand to suppress T cells in autoimmunity and anti-cancer immunity.

Source: Immunity - April 11, 2022 Category: Allergy & Immunology Authors: Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Kenji Shimizu, Takeo K. Maeda, Jun Ikubo, Harunori Yoshikawa, Katsumi Maenaka, Naozumi Ishimaru, Hidetaka Kosako, Tatsuya Takemoto, Taku Okazaki Tags: Article Source Type: research