TRIM11 expression in non-small cell lung cancer is associated with poor prognosis
CONCLUSIONS: High TRIM11 expression is linked with a poor prognosis and might serve as a promising novel prognostic biomarker. Its assessment could be implemented in future routine diagnostic workup.PMID:37409491 | DOI:10.14670/HH-18-647 (Source: Histology and Histopathology)
Source: Histology and Histopathology - July 6, 2023 Category: Cytology Authors: Christiane Kuempers Tobias Jagomast Finn-Ole Paulsen Carsten Heidel Sabine Bohnet Stefanie Schierholz Markus Reischl Eva Dreyer Till Olchers Martin Reck Jutta Kirfel Sven Perner Source Type: research
Helicobacter pylori vacA affects the expression of COX-2 in the duodenal mucosa of patients with duodenitis
Histol Histopathol. 2023 Jun 22:18645. doi: 10.14670/HH-18-645. Online ahead of print.ABSTRACTDuodenitis refers to inflammation that occurs in the duodenum. Helicobacter pylori (Hp) is a known risk factor for duodenitis. This paper attempted to analyze the correlation between Hp virulence genotypes and the initiation and development of duodenal bulbar inflammation (DBI) to lay the foundation for the management of duodenitis induced by Hp infection. Total RNA was extracted from duodenal samples of 156 Hp-positive patients [70 with DBI and 86 with duodenal bulbar ulcer (DBU)] and 80 Hp-free DBI patients, followed by RT-qPCR ...
Source: Histology and Histopathology - June 29, 2023 Category: Cytology Authors: Yan Chu Fengyuan Chen Qincong Pan Nuo Cheng Xiuping Liu Jie Feng Source Type: research
Optimizing assessment of CD30 expression in Hodgkin lymphoma by controlling for low expression
In this study, we examined 29 cases of CHL and 4 cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) for CD30 expression using a staining protocol that was designed to detect low CD30 expression levels, and an evaluation system similar to the Allred scoring system used for breast cancer evaluation. For CHL, 10% of cases had low scores and 3% were CD30 negative, with 3 cases in which the majority of tumor cells showed very weak staining. Unexpectedly, one of four cases of NLPHL was positive. We demonstrate intra-patient heterogeneity in CD30 expression levels and staining patterns in tumor cells. Three CHL case...
Source: Histology and Histopathology - June 28, 2023 Category: Cytology Authors: Shoib Sarwar Margaret E Tome Dean Billheimer Catherine Spier Catharine L Smith Daniel Persky Monika Schmelz Source Type: research
