Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators
Histol Histopathol. 2023 Dec 13:18689. doi: 10.14670/HH-18-689. Online ahead of print.ABSTRACTAlthough endogenous ligands for the orphan nuclear receptor 4A1 (NR4A1, Nur77), NR4A2 (Nurr1), and NR4A3 (Nor-1) have not been identified, several natural products and synthetic analogs bind NR4A members. These studies are becoming increasingly important since members of the NR4A subfamily of 3 receptors are potential drug targets for treating cancer and non-cancer endpoints and particularly those conditions associated with inflammatory diseases. Ligands that bind NR4A1, NR4A2, and NR4A3 including Cytosporone B, celastrol, bis-ind...
Source: Histology and Histopathology - December 20, 2023 Category: Cytology Authors: Stephen Safe Source Type: research
Inflammatory suppression and immunity regulation benefits of honokiol in a rat model of acute peritonitis via the regulation of NLRP3 inflammasome and Sirt1/autophagy axis
CONCLUSIONS: HNK improved AP by inhibiting NLRP3 inflammasome and activating the Sirt1 autophagy axis in vivo and in vitro.PMID:38112214 | DOI:10.14670/HH-18-688 (Source: Histology and Histopathology)
Source: Histology and Histopathology - December 19, 2023 Category: Cytology Authors: Ximing Pan Zhou Hua Guocai Fan Qinglong Feng Source Type: research
Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception
CONCLUSIONS: Stronger analgesic effects by peroral CYY were observed compared with reference standards in two IBS-like mouse models. The 5-HT₇-dependent NTR upregulation and neurite elongation may be involved in intestinal hypernociception.PMID:38108436 | DOI:10.14670/HH-18-687 (Source: Histology and Histopathology)
Source: Histology and Histopathology - December 18, 2023 Category: Cytology Authors: Meng-Ping She Yu-Ting Hsieh Li-Yu Lin Chia-Hung Tu Ming-Shiang Wu Ling-Wei Hsin Linda Chia-Hui Yu Source Type: research
