Mechanism of Weiwei granules in the treatment of chronic active Helicobacter pylori gastritis with atrophy based on the TLR4/NF- κB/COX-2 inflammatory signaling pathway
CONCLUSION: Weiwei granules can effectively improve Hp-positive CAG patients and reduce the expression levels of TLR4, NF-κB, and COX-2.PMID:38031901 | DOI:10.14670/HH-18-679 (Source: Histology and Histopathology)
Source: Histology and Histopathology - November 30, 2023 Category: Cytology Authors: Haipeng Zhang Hongyan Liu Source Type: research
ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma
Histol Histopathol. 2023 Nov 22:18678. doi: 10.14670/HH-18-678. Online ahead of print.ABSTRACTLysosomal-associated transmembrane protein 5 (LAPTM5) has been associated with poor prognosis in cancer patients. Its role in regulating metastasis in pancreatic ductal adenocarcinoma (PDAC), however, remains vague. The study here aimed to expound the metastasis-promoting properties of LAPTM5 in PDAC and the detailed mechanism. LAPTM5 was overexpressed in metastatic PDAC cells and was related to the dismal prognosis of patients in GEO datasets. By using lentiviral vectors harboring short hairpin RNA, we found that LAPTM5 downregul...
Source: Histology and Histopathology - November 29, 2023 Category: Cytology Authors: Yong Yang Wei Xie Xuan Qiao Jun Yang Dan Yao Dongming Zhu Source Type: research
UBE2R2-AS1, as a prognostic marker of gastric cancer, promotes the malignant phenotype of gastric cancer cells
CONCLUSION: The expression of UBE2R2-AS1 allowed the prognostic stratification of gastric cancer patients. UBE2R2-AS1 may accelerate the progression of gastric cancer via miR-302b-5p.PMID:38009743 | DOI:10.14670/HH-18-677 (Source: Histology and Histopathology)
Source: Histology and Histopathology - November 27, 2023 Category: Cytology Authors: Jie Xu Meiqin Xiao Zhijun Huang Zhiyao Chen Jianqing Lin Source Type: research
Ethyl acetate extracted from the chinese medicinal plant Caesalpinia sappan L alleviates gustatory response in diabetes mellitus rats
CONCLUSION: The current study highlighted the alleviative role of EtOAc extracts of C. sappan in gustatory response in DM rats via the regulation of taste-regulatory peptides in taste cells and the hypothalamus.PMID:37997936 | DOI:10.14670/HH-18-676 (Source: Histology and Histopathology)
Source: Histology and Histopathology - November 24, 2023 Category: Cytology Authors: Xun Cao Li Cui Wen Yang Source Type: research
Podocyte involvement in the pathogenesis of preterm-related long-term chronic kidney disease
Histol Histopathol. 2023 Nov 15:18675. doi: 10.14670/HH-18-675. Online ahead of print.ABSTRACTWith the continuous advancement of neonatal intensive care technology, the survival rate of preterm infants is gradually increasing. However, this improvement in survival is accompanied by long-term prognostic implications in various systems. In the field of renal diseases, current epidemiological data indicate that preterm birth is a significant risk factor for the development of long-term chronic kidney disease (CKD). This not only imposes an economic burden on patients families but also severely impacts their quality of life. U...
Source: Histology and Histopathology - November 23, 2023 Category: Cytology Authors: Lulu Zhang Jun Zheng Fangrui Ding Source Type: research
The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer
In this study, we found that Grin2d expression was higher in esophageal cancer than in normal mucosa at both the mRNA and protein level using RT-PCR, bioinformatics analysis, and western blotting (p<0.05). Grin2d mRNA expression was positively correlated with old age, white race, heavy weight, distal location, adenocarcinoma, cancer with Barrett's lesion, or high-grade columnar dysplasia (p<0.05). The differential genes associated with Grin2d mRNA were involved in fat digestion and absorption, cholesterol metabolism, lipid transfer, lipoproteins, synaptic membranes, and ABC transporters (p<0.05). The Grin2d-relate...
Source: Histology and Histopathology - November 20, 2023 Category: Cytology Authors: Ling-Ling Wang Jun Li Hang Xue Li Zhang Da-Yong Yu Ning Yang Wen-Jing Yun Ming-Zhen Zhao Hang Xue Source Type: research
