Localization of advanced glycation end-products and their receptor in tendinopathic lesions
This study was designed to investigate the accumulation of advanced glycation end-products (AGEs) and the expression of the receptor of AGEs (RAGE) in tendinopathic tissues. In this study, tendinopathic posterior tibial tendons (PTT) were collected from patients (n=6). Redundant autografts of flexor digitorum longus tendon (FDL; n=3) were used for controls. The control and tendinopathic tendon tissues were used for extraction of proteins for western blot and sectioned for histology and immunohistochemistry. Tendinopathy of the PTT was confirmed histologically by the presentation of disorderly organized collagen fibers, hig...
Source: Histology and Histopathology - February 7, 2024 Category: Cytology Authors: Eva Asomugha Young Cho Sharada Paudel Yi Guo Lew Schon Zijun Zhang Source Type: research
Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells
CONCLUSION: The current study suggested that INPP4B could be a suppressor in endometrial cancer progression and might be a target for endometrial cancer treatment. Also, INPP4B might serve as a predictor of chemosensitivity determination.PMID:38318760 | DOI:10.14670/HH-18-711 (Source: Histology and Histopathology)
Source: Histology and Histopathology - February 6, 2024 Category: Cytology Authors: Jing Zhao Xue-Mei Du Wen Si Xian-He Zhao Zi-Qi Zhou Source Type: research
Role of mitochondria in neonatal hypoxic-ischemic encephalopathy
Histol Histopathol. 2024 Jan 15:18710. doi: 10.14670/HH-18-710. Online ahead of print.ABSTRACTNeonatal hypoxic-ischemic encephalopathy, an important cause of death as well as long-term disability in survivors, is caused by oxygen and glucose deprivation, and limited blood flow. Following hypoxic-ischemic injury in the neonatal brain, three main biochemical damages (excitotoxicity, oxidative stress, and exacerbated inflammation) are triggered. Mitochondria are involved in all three cascades. Mitochondria are the nexus of metabolic pathways to offer most of the energy that our body needs. Hypoxic-ischemic injury affects the ...
Source: Histology and Histopathology - February 5, 2024 Category: Cytology Authors: Weijing Kong Cheng Lu Source Type: research
Genotype-histotype-phenotype correlations in hyperinsulinemic hypoglycemia
Histol Histopathol. 2024 Jan 12:18709. doi: 10.14670/HH-18-709. Online ahead of print.ABSTRACTHyperinsulinemic hypoglycemia (HH) of pancreatic origin includes congenital hyperinsulinism (CHI), insulinoma, insulinomatosis, and adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia syndrome (NI-PHHS). In this review, we describe the genotype-histotype-phenotype correlations in HH and their therapeutic implications. CHI can occur from birth or later on in life. Histologically, diffuse CHI shows diffuse beta cell hypertrophy with a few giant nuclei per islet of Langerhans, most frequently caused by loss-of-functio...
Source: Histology and Histopathology - February 2, 2024 Category: Cytology Authors: Annette R ønholt Larsen Klaus Brusgaard Henrik Thybo Christesen S önke Detlefsen Source Type: research
Quantification of eosinophils in the lower gastrointestinal tract of adults: a review of surgical specimens with normal histology from the Free State province, South Africa
CONCLUSIONS: Specific eosinophil reference ranges were formulated to quantify reference ranges of eosinophils in the lower GIT, allowing for the accurate diagnosis of EGIDs in our population in future.PMID:38299224 | DOI:10.14670/HH-18-708 (Source: Histology and Histopathology)
Source: Histology and Histopathology - February 1, 2024 Category: Cytology Authors: Jane E Duncan Gina Joubert Jacqueline Goedhals Source Type: research
Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions
In conclusion, our results showed the Plexin-B2-Sema4C system was abnormally expressed in cortical lesions of TSC and FCD IIb patients, signifying that the Plexin-B2-Sema4C system may play a role in the pathogenic development of TSC and FCD IIb.PMID:38293776 | DOI:10.14670/HH-18-707 (Source: Histology and Histopathology)
Source: Histology and Histopathology - January 31, 2024 Category: Cytology Authors: Lu Dai Jun Huang Kai-Feng Shen Xiao-Lin Yang Gang Zhu Li Zhang Zhong-Ke Wang Shi-Yong Liu Xiang Liao Sen-Lin Xu Hui Yang Xing-Yi Li Chun-Qing Zhang Source Type: research
Rapamycin mitigates organ damage by autophagy-mediated NLRP3 inflammasome inactivation in sepsis
This study aimed to assess whether Rap protects rats from cecal ligation and puncture (CLP)-induced sepsis through autophagy-mediated inactivation of the NLRP3 inflammasome. Rats were allocated to the sham, CLP, Rap (10 mg/kg), or 3-Methyladenine (3-MA) (15 mg/kg) groups. A rat CLP model was established. The survival of rats and lung wet-to-dry weight ratio in each group was assessed. Blood biochemical indexes and oxidative stress-related factors were analyzed with an automatic biochemical analyzer. The bacterial counts of blood and organs were monitored. The degrees of myeloperoxidase of the ileum, inflammation-related in...
Source: Histology and Histopathology - January 30, 2024 Category: Cytology Authors: Xiaofeng Li Qingqiu Zeng Rui Yao Lingyan Zhang Ying Kong Bin Shen Source Type: research
Targeting PEAK1 sensitizes anaplastic thyroid carcinoma cells harboring BRAF < sup > V600E < /sup > to Vemurafenib by Bim upregulation
In conclusion, vemurafenib resistance in ATC cells harboring BRAFV600E is associated with PEAK1 activation, resulting in the inhibition of pro-apoptotic Bim protein. Therefore, targeting PEAK1 may be an effective strategy to sensitize ATC harboring BRAFV600E to vemurafenib.PMID:38284248 | DOI:10.14670/HH-18-705 (Source: Histology and Histopathology)
Source: Histology and Histopathology - January 29, 2024 Category: Cytology Authors: Qiuhan Wang Fengyun Hao Liang Ning Chong Sun Source Type: research
Astragaloside IV induces endothelial progenitor cell angiogenesis in deep venous thrombosis through inactivation of PI3K/AKT signaling
CONCLUSION: AS-IV prevents thrombus in an experimental DVT model by facilitating EPC angiogenesis and decreasing inflammation through inactivation of PI3K/AKT signaling.PMID:38275076 | DOI:10.14670/HH-18-704 (Source: Histology and Histopathology)
Source: Histology and Histopathology - January 26, 2024 Category: Cytology Authors: Xiaojiang Lyu Zhigang Yi Yun He Chunfeng Zhang Ping Zhu Chonghai Liu Source Type: research
Transcription factor YY1 accelerates hepatic fibrosis development by activating NLRP3 inflammasome-mediated pyroptosis
Histol Histopathol. 2024 Jan 4:18703. doi: 10.14670/HH-18-703. Online ahead of print.ABSTRACTHepatic fibrosis is the basis of multiple liver diseases and may eventually develop into hepatocellular carcinoma. Hepatic stellate cell (HSC) activation is a driving factor of hepatic fibrogenesis. In the liver microenvironment, liver cells and others play a crucial role in HSC activation. The liver tissues of CCl4-induced rats show excessive fibrosis, inflammation, and cell apoptosis. Yin Yang 1 (YY1) was highly expressed in hepatic fibrosis rats and TGF-β1-treated liver cells. In animal experiments, YY1 knockdown effectively at...
Source: Histology and Histopathology - January 24, 2024 Category: Cytology Authors: Xiao Fu Ping Xiao Xin Luo Ninghong Guo Source Type: research
Heraclenin promotes the osteogenic differentiation of bone marrow stromal cells by activating the RhoA/ROCK pathway
CONCLUSION: Heraclenin facilitates the osteogenic differentiation of human BMSCs through the activation of the RhoA/ROCK pathway.PMID:38258549 | DOI:10.14670/HH-18-702 (Source: Histology and Histopathology)
Source: Histology and Histopathology - January 23, 2024 Category: Cytology Authors: Zuguang Yu Jun Yuan Yuanyuan Yu Source Type: research
Expression of the HIF-1 α/VEGF pathway is upregulated to protect alveolar bone density reduction in nasal-obstructed rats
CONCLUSION: Bilateral nasal obstruction changes alveolar bone structure and leads to a reduction in alveolar bone density. Moreover, the expression of the HIF-1α/VEGF signaling pathway increases to protect alveolar bone density reduction in BNO rats.PMID:38235568 | DOI:10.14670/HH-18-701 (Source: Histology and Histopathology)
Source: Histology and Histopathology - January 18, 2024 Category: Cytology Authors: Zishan Liu Yongming Li Source Type: research
Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients
Histol Histopathol. 2023 Dec 29:18700. doi: 10.14670/HH-18-700. Online ahead of print.ABSTRACTPancreatic cancer is a highly lethal malignancy with a growing incidence reported worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, which is often diagnosed at advanced stages, making its prognosis and medical management difficult. The identification of histopathological biomarkers has allowed a more precise stratification of pancreatic cancer patients, providing additional information about their prognosis and offering possible therapeutic targets to be explored. The prognostic value...
Source: Histology and Histopathology - January 17, 2024 Category: Cytology Authors: Miguel A Ortega Laura Jim énez-Álvarez Oscar Fraile-Martinez Cielo Garcia-Montero Diego De Le ón-Oliva Mar ía Del Val Toledo-Lobo Esther Palacios Paula Granado Alfonso Esteban Luis G Guijarro Leonel Pekarek Ángel Asúnsolo Laura L ópez-González Jul Source Type: research
Molecular changes underlying pulmonary emphysema and chronic bronchitis in Chronic Obstructive Pulmonary Disease: An updated review
Histol Histopathol. 2023 Dec 28:18699. doi: 10.14670/HH-18-699. Online ahead of print.ABSTRACTThe aim of this review is to update and synthesize the molecular mechanisms that lead to the heterogeneous effect on tissue remodeling observed in the two most important clinical phenotypes of chronic obstructive pulmonary disease (COPD), pulmonary emphysema (PE) and chronic bronchitis (CB). Clinical and experimental evidence suggests that this heterogeneous response to promote PE, CB, or both, is related to differentiated genetic, epigenetic, and molecular conditions. Specifically, a tendency toward PE could be related to a varia...
Source: Histology and Histopathology - January 16, 2024 Category: Cytology Authors: Elia A Baltazar-Garc ía Belinda Vargas-Guerrero Luz E Gasca-Lozano Carmen M Gurrola-D íaz Source Type: research
Impact of maternal stress on metabolism and penile morphology in young offspring rats
Histol Histopathol. 2023 Dec 27:18698. doi: 10.14670/HH-18-698. Online ahead of print.ABSTRACTExposure to prolonged stress in pregnancy and/or lactation can lead to the future development of diseases. We aimed to study the effects of maternal stress on the biometry, metabolism, and penile morphology of young Wistar rats. Animals were divided into two experimental groups: Control Group (C) - pups from control mothers, without any intervention (n=5); and Chronic Stress Group (S) - pups from mothers who suffered variable stress in the third week of pregnancy (14th to 21st day; n=5). Food intake and body mass of the pups (n=10...
Source: Histology and Histopathology - January 15, 2024 Category: Cytology Authors: Carolinne Macedo Juliana Monnerat Bianca Lucchetti Gabriel Teixeira Juliana Mentzinger Helena Rocha Renata Medeiros Nat ália Rocha Diogo de Souza Francisco Sampaio Bianca Gregorio Source Type: research
