Effects of sinomenine on a rat orthotopic liver carcinoma model
CONCLUSION: A rat orthotopic liver carcinoma model was established under the guidance of B-ultrasound, and Sin had a therapeutic effect on orthotopic liver carcinoma.PMID:38084512 | DOI:10.14670/HH-18-683 (Source: Histology and Histopathology)
Source: Histology and Histopathology - December 12, 2023 Category: Cytology Authors: Yunlong Zhang Hongmei Ran Shanshan Hui Liping Qian Source Type: research
Clinicopathological analysis of bronchiolar adenoma combined with lung adenocarcinoma: Report of eight cases and literature review
CONCLUSION: There is no obvious boundary when BA and LUAD are in the same lesion. The luminal epithelial cells in the area where the two components migrate toward each other are atypical and lack a continuous underlying basal cell layer. Microscopic diagnosis should be aided by immunohistochemistry.PMID:38059279 | DOI:10.14670/HH-18-682 (Source: Histology and Histopathology)
Source: Histology and Histopathology - December 7, 2023 Category: Cytology Authors: Minsheng Zhu Qianqian Yang Shenghua Zhan Weishuo Liu Wei Liu Lingchuan Guo Shan Huang Source Type: research
Region-specific response of central microglial cells to sciatic nerve demyelination through sensory and motor pathways
Histol Histopathol. 2023 Nov 28:18681. doi: 10.14670/HH-18-681. Online ahead of print.ABSTRACTPeripheral nerve injury can cause changes in microglial cells on the spinal dorsal and ventral horns. This region-specific response implies that central microglial cells could be activated through both sensory and motor pathways. In order to further determine how peripheral nerve injury activates central microglial cells through neural pathways, the sciatic nerve was selected as the target for neural tract tracing and demyelination. Firstly, we used cholera toxin subunit B (CTB) to map the central sensory and motor territories of ...
Source: Histology and Histopathology - December 5, 2023 Category: Cytology Authors: Shuang Wu Yuxin Su Yuqing Wang Jia Wang Dongsheng Xu Yihan Liu Kunwu Yang Junhong Gao Jingjing Cui Wanzhu Bai Source Type: research
CBP-mediated FOXO4 acetylation facilitates postmenopausal osteoporosis (PMO) progression through the inhibition of the Wnt/ β-catenin signaling pathway
Histol Histopathol. 2023 Nov 27:18680. doi: 10.14670/HH-18-680. Online ahead of print.ABSTRACTFOXO4 was previously identified as a potential biomarker and therapeutic target for postmenopausal osteoporosis (PMO) using bioinformatic analysis, but its specific function and molecular mechanism in the progression of osteoporosis was not reported. The current study was designed to investigate the biological function and underlying mechanism of FOXO4 in PMO. Our results showed that FOXO4 expression was significantly upregulated in the serum samples of PMO patients, which was also negatively correlated with the expression of oste...
Source: Histology and Histopathology - December 1, 2023 Category: Cytology Authors: Qiubo Huang Jiang Wang Source Type: research
Mechanism of Weiwei granules in the treatment of chronic active Helicobacter pylori gastritis with atrophy based on the TLR4/NF- κB/COX-2 inflammatory signaling pathway
CONCLUSION: Weiwei granules can effectively improve Hp-positive CAG patients and reduce the expression levels of TLR4, NF-κB, and COX-2.PMID:38031901 | DOI:10.14670/HH-18-679 (Source: Histology and Histopathology)
Source: Histology and Histopathology - November 30, 2023 Category: Cytology Authors: Haipeng Zhang Hongyan Liu Source Type: research
ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma
Histol Histopathol. 2023 Nov 22:18678. doi: 10.14670/HH-18-678. Online ahead of print.ABSTRACTLysosomal-associated transmembrane protein 5 (LAPTM5) has been associated with poor prognosis in cancer patients. Its role in regulating metastasis in pancreatic ductal adenocarcinoma (PDAC), however, remains vague. The study here aimed to expound the metastasis-promoting properties of LAPTM5 in PDAC and the detailed mechanism. LAPTM5 was overexpressed in metastatic PDAC cells and was related to the dismal prognosis of patients in GEO datasets. By using lentiviral vectors harboring short hairpin RNA, we found that LAPTM5 downregul...
Source: Histology and Histopathology - November 29, 2023 Category: Cytology Authors: Yong Yang Wei Xie Xuan Qiao Jun Yang Dan Yao Dongming Zhu Source Type: research