Female fertility and the mammalian egg's zona pellucida
Histol Histopathol. 2024 Mar 4:18728. doi: 10.14670/HH-18-728. Online ahead of print.ABSTRACTAll mammalian eggs are surrounded by a relatively thick extracellular matrix (ECM) or zona pellucida (ZP) to which free-swimming sperm bind in a species-restricted manner during fertilization. The ZP consists of either three (e.g., Mus musculus) or four (e.g., Homo sapiens) glycosylated proteins, called ZP1-4. These proteins are unlike those found in somatic cell ECM, are encoded by single-copy genes on different chromosomes, and are well conserved among different mammals. Mammalian ZP proteins are synthesized as polypeptide precur...
Source: Histology and Histopathology - March 15, 2024 Category: Cytology Authors: Paul M Wassarman Eveline S Litscher Source Type: research
The immune microenvironment of cancer of the uterine cervix
Histol Histopathol. 2024 Mar 1:18727. doi: 10.14670/HH-18-727. Online ahead of print.ABSTRACTWhile several treatment choices exist for cervical cancer, such as surgical therapy, chemotherapy, and radiotherapy, some patients will still show poor prognosis. HPV infection is a principal factor for cervical cancer development, from early inflammation to proliferation, angiogenesis, and neoplastic growth. While HPV T-cell responses exist, the tumor seems to evade the immune system upon its tolerance. The latter suggests the existence of a confluent tumor microenvironment responsible for the evasion tactics employed by the neopl...
Source: Histology and Histopathology - March 14, 2024 Category: Cytology Authors: Michail Mastrogeorgiou Elena Chatzikalil Stamatios Theocharis Alexandra Papoudou-Bai Michel P éoc'h Mousa Mobarki Georgia Karpathiou Source Type: research
Biological action of bleaching agents on tooth structure: A review
Histol Histopathol. 2024 Feb 28:18726. doi: 10.14670/HH-18-726. Online ahead of print.ABSTRACTThe use of bleaching agents to remove stains is one of the main dental procedures to improve the aesthetics of teeth. This review presents the main agents used for tooth whitening, existing clinical protocols, and the structural changes that may occur through their use. The main bleaching agents consist of hydrogen peroxide and carbamide peroxide, which are used in bleaching techniques for vital teeth. These techniques can be performed in the office by a professional or by the individual in a home en-vironment under professional g...
Source: Histology and Histopathology - March 13, 2024 Category: Cytology Authors: Walessa Alana Bragan ça Aragão Vict ória Santos Chemelo Cristiane de Melo Alencar Cecy Martins Silva Sofia Pessanha Alessandra Reis Renata Duarte de Souza Rodrigues Rafael Rodrigues Lima Source Type: research
Upregulation of LY6K induced by FTO-mediated demethylation promotes the tumorigenesis and metastasis of oral squamous cell carcinoma via CAV-1-mediated ERK1/2 signaling activation
Histol Histopathol. 2024 Feb 27:18725. doi: 10.14670/HH-18-725. Online ahead of print.ABSTRACTLymphocyte antigen 6 complex locus K (LY6K) has been demonstrated to play a significant role in cancers and identified as a therapeutic biomarker for head and neck squamous cell carcinoma. However, the role of LY6K in oral squamous cell carcinoma (OSCC) has not been explored. The current study discovered that LY6K was aberrantly upregulated in OSCC cell lines and tissues and that high LY6K expression significantly correlated with poorer survival of OSCC patients. Through stable knockdown of LY6K, we found that the growth, colony f...
Source: Histology and Histopathology - March 12, 2024 Category: Cytology Authors: Rujuan Gong Chen Xu Haibing Yang Source Type: research
Upregulation of LY6K induced by FTO-mediated demethylation promotes the tumorigenesis and metastasis of oral squamous cell carcinoma via CAV-1-mediated ERK1/2 signaling activation
Histol Histopathol. 2024 Feb 27:725. doi: 10.14670/HH-18-725. Online ahead of print.ABSTRACTLymphocyte antigen 6 complex locus K (LY6K) has been demonstrated to play a significant role in cancers and identified as a therapeutic biomarker for head and neck squamous cell carcinoma. However, the role of LY6K in oral squamous cell carcinoma (OSCC) has not been explored. The current study discovered that LY6K was aberrantly upregulated in OSCC cell lines and tissues and that high LY6K expression significantly correlated with poorer survival of OSCC patients. Through stable knockdown of LY6K, we found that the growth, colony for...
Source: Histology and Histopathology - March 12, 2024 Category: Cytology Authors: Rujuan Gong Chen Xu Haibing Yang Source Type: research
Enhanced autophagy and phagocytosis of apoptotic lymphocytes in splenic macrophages of acute ethanol-treated rats: Light and electron microscopic studies
Histol Histopathol. 2024 Mar 5:18729. doi: 10.14670/HH-18-729. Online ahead of print.ABSTRACTAutophagy is a prosurvival mechanism for the clearance of damaged cellular components, specifically upon exposure to various stressors. In lymphoid organs, excessive ethanol consumption increases lymphocyte apoptosis, resulting in immunosuppression. However, ethanol-induced autophagy and related phagocytosis of apoptotic lymphocytes in the spleen have not been studied yet. Adult male Wistar rats were injected intraperitoneally either with 5 g/kg ethanol or phosphate-buffered saline (as a control group) and then sacrificed 0, 3, 6, ...
Source: Histology and Histopathology - March 11, 2024 Category: Cytology Authors: Tsubasa Betsuyaku Yuko Ito Nicholas Peake Abdul Alim Al-Bari Gehan El-Akabawy Nabil Eid Source Type: research
