Duodenal-Jejunal bypass improves metabolism and re-models extra cellular matrix through modulating ceRNA network
CONCLUSIONS: The role of DJB in adipose tends to remodel ECM and improve the energy metabolism through the ceRNA regulatory network.PMID:37972907 | DOI:10.1016/j.ygeno.2023.110744 (Source: Genomics)
Source: Genomics - November 16, 2023 Category: Genetics & Stem Cells Authors: Qingnan Zhao Jiaxin Cheng Aimei Gao Jianqiao Wang Huiping Lu Shan Jiang Xiaojing Li Jiahao Ni Wenmin Dong Shenjin Lai Jingru Gong Han Zhu Yongjun Liang Source Type: research
ER- β accelerates the process of primary osteoporosis by promoting VEGFA-mediated apoptosis of osteoblasts
In conclusion, this study identifies that the roles of ER-β in the regulation of osteoblast apoptosis are closely related to VEGFA and provides a new target for POP treatment.PMID:37967683 | DOI:10.1016/j.ygeno.2023.110743 (Source: Genomics)
Source: Genomics - November 15, 2023 Category: Genetics & Stem Cells Authors: Zhujie Xu Peng Wang Zhenyu Wang Hao Cui Tianshu Gao Zhenting Wang Yi Liu Source Type: research
Deep sequencing reveals recurrent somatic mutations and distinct molecular subgroups in gastric cancer in Mizo population, North East India
Genomics. 2023 Nov 13:110741. doi: 10.1016/j.ygeno.2023.110741. Online ahead of print.ABSTRACTIn India, Mizoram has the highest incidence of gastric cancer (GC) which might be associated with environmental factors such as diet, Helicobacter pylori (H.pylori) and Epstein-Barr virus (EBV) infections, and somatic genomic alterations. We performed PCR cum sequencing and fragment analysis for detection of H. pylori/EBV infection and microsatellite Instability (MSI) in GC patients (N = 68). Somatic mutations were identified by targeted and exome sequencing. We found 87% of GC patients infected with H. pylori and EBV. Pathogenic ...
Source: Genomics - November 15, 2023 Category: Genetics & Stem Cells Authors: Payel Chakraborty Sillarine Kurkalang Souvik Ghatak Subrata Das Arindam Palodhi Sumanta Sarkar Ranjan Dhar Saia Chenkual Lalawmpuii Pachuau John Zohmingthanga Jeremy L Pautu Thomas Zomuana Sailo Tlau Lalruatfela John Zothanzama Nachimuthu Senthil Kumar Ar Source Type: research
Resistome, mobilome, virulome analysis and phylogenomics of Enterococcus faecalis isolated from raw muscle foods of beef origin in Gauteng, South Africa
This study provides insight into the genomic characteristics, antimicrobial resistance genes, virulence factors, and genetic mobile elements associated with eight E. faecalis isolates from processed beef meat in the Gauteng province of South Africa.PMID:37967685 | DOI:10.1016/j.ygeno.2023.110742 (Source: Genomics)
Source: Genomics - November 15, 2023 Category: Genetics & Stem Cells Authors: Itumeleng Matle Abimbola Comfort Atanda Rian Pierneef Kudakwashe Magwedere Thendo Mafuna Source Type: research
ER- β accelerates the process of primary osteoporosis by promoting VEGFA-mediated apoptosis of osteoblasts
In conclusion, this study identifies that the roles of ER-β in the regulation of osteoblast apoptosis are closely related to VEGFA and provides a new target for POP treatment.PMID:37967683 | DOI:10.1016/j.ygeno.2023.110743 (Source: Genomics)
Source: Genomics - November 15, 2023 Category: Genetics & Stem Cells Authors: Zhujie Xu Peng Wang Zhenyu Wang Hao Cui Tianshu Gao Zhenting Wang Yi Liu Source Type: research
Deep sequencing reveals recurrent somatic mutations and distinct molecular subgroups in gastric cancer in Mizo population, North East India
Genomics. 2023 Nov 13:110741. doi: 10.1016/j.ygeno.2023.110741. Online ahead of print.ABSTRACTIn India, Mizoram has the highest incidence of gastric cancer (GC) which might be associated with environmental factors such as diet, Helicobacter pylori (H.pylori) and Epstein-Barr virus (EBV) infections, and somatic genomic alterations. We performed PCR cum sequencing and fragment analysis for detection of H. pylori/EBV infection and microsatellite Instability (MSI) in GC patients (N = 68). Somatic mutations were identified by targeted and exome sequencing. We found 87% of GC patients infected with H. pylori and EBV. Pathogenic ...
Source: Genomics - November 15, 2023 Category: Genetics & Stem Cells Authors: Payel Chakraborty Sillarine Kurkalang Souvik Ghatak Subrata Das Arindam Palodhi Sumanta Sarkar Ranjan Dhar Saia Chenkual Lalawmpuii Pachuau John Zohmingthanga Jeremy L Pautu Thomas Zomuana Sailo Tlau Lalruatfela John Zothanzama Nachimuthu Senthil Kumar Ar Source Type: research
Resistome, mobilome, virulome analysis and phylogenomics of Enterococcus faecalis isolated from raw muscle foods of beef origin in Gauteng, South Africa
This study provides insight into the genomic characteristics, antimicrobial resistance genes, virulence factors, and genetic mobile elements associated with eight E. faecalis isolates from processed beef meat in the Gauteng province of South Africa.PMID:37967685 | DOI:10.1016/j.ygeno.2023.110742 (Source: Genomics)
Source: Genomics - November 15, 2023 Category: Genetics & Stem Cells Authors: Itumeleng Matle Abimbola Comfort Atanda Rian Pierneef Kudakwashe Magwedere Thendo Mafuna Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure
CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737 (Source: Genomics)
Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research
