Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure

CONCLUSIONS: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.PMID:37926353 | DOI:10.1016/j.ygeno.2023.110737

Source: Genomics - November 5, 2023 Category: Genetics & Stem Cells Authors: Zhi-Hui Li Jun-Yi Wang Xian-Long Li Shi-Bo Meng Hui-Yuan Zheng Jia-Lei Wang Zi-Ying Lei Bing-Liang Lin Jing Zhang Source Type: research