Sex-specific transcriptome of the chicken chorioallantoic membrane
This study provides evidence that gene expression of extra-embryonic membranes is differentially regulated between male and female embryos. As such a better characterisation of associated mechanisms should facilitate the identification of new sex-specific biomarkers.PMID:38061480 | DOI:10.1016/j.ygeno.2023.110754 (Source: Genomics)
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Maeva Halgrain Nelly Bernardet Christelle Hennequet-Antier Sophie R éhault-Godbert Source Type: research
RNA-Seq profiling of circular RNAs in mice with lipopolysaccharide-induced acute lung injury
In this study, circRNA profiles are remarkably changed in mice with LPS-triggered ALI, and their potential contribution to the disease is revealed.PMID:38061481 | DOI:10.1016/j.ygeno.2023.110755 (Source: Genomics)
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Xianxian Jia Jinhui Huang Bo Wu Miao Yang Wei Xu Source Type: research
Whole genome sequencing of Crassostrea ariakensis (Mollusca: Ostreidae) and C. hongkongensis expands understandings of stress resistance in sessile oysters
Genomics. 2023 Dec 5:110757. doi: 10.1016/j.ygeno.2023.110757. Online ahead of print.ABSTRACTTo understand the environmental adaptations among sessile bivalves lacking adaptive immunity, a series of analyses were conducted, with special emphasis on the widely distributed C. ariakensis. Employing Pacbio sequencing and Hi-C technologies, whole genome for each of a C. ariakensis (southern China) and C. hongkongensis individual was generated, with the contig N50 reaching 6.2 and 13.0 Mb, respectively. Each genome harbored over 30,000 protein-coding genes, with approximately half of each genome consisting of repeats. Genome ali...
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Xingzhi Zhang Junliang Guan Ming Zou Pingping He Li Zhang Yongxian Chen Wei Li Dapeng Wang Ermeng Yu Fangjie Zhong Peng Zhu Xueyu Yan Youhou Xu Bang Luo Ting Huang Linyuan Jiang Pinyuan Wei Jinxia Peng Source Type: research
Using two self-developed InDel panels to explore forensic feature and population genetic structure in the Hui group
Genomics. 2023 Dec 5:110756. doi: 10.1016/j.ygeno.2023.110756. Online ahead of print.ABSTRACTTo address the challenges faced by forensic examiners in degraded DNA analysis, we have developed two different panels for various forensic applications, encompassing the AIM-InDel panel for ancestry inference and the Multi-InDel panel for individual identification, respectively. Herein, the efficiencies of these two panels were tested in the Chinese Hui group. By calculating forensic parameters and simulating family relationships, we verified that the Multi-InDel panel could be an effective tool for individual identification, pate...
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Xi Yuan Xi Wang Qiong Lan Shuanglin Li Yifeng Lin Ming Zhao Hui Xu Fanzhang Lei Chunmei Shen Bofeng Zhu Source Type: research
Sex-specific transcriptome of the chicken chorioallantoic membrane
This study provides evidence that gene expression of extra-embryonic membranes is differentially regulated between male and female embryos. As such a better characterisation of associated mechanisms should facilitate the identification of new sex-specific biomarkers.PMID:38061480 | DOI:10.1016/j.ygeno.2023.110754 (Source: Genomics)
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Maeva Halgrain Nelly Bernardet Christelle Hennequet-Antier Sophie R éhault-Godbert Source Type: research
RNA-Seq profiling of circular RNAs in mice with lipopolysaccharide-induced acute lung injury
In this study, circRNA profiles are remarkably changed in mice with LPS-triggered ALI, and their potential contribution to the disease is revealed.PMID:38061481 | DOI:10.1016/j.ygeno.2023.110755 (Source: Genomics)
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Xianxian Jia Jinhui Huang Bo Wu Miao Yang Wei Xu Source Type: research
Whole genome sequencing of Crassostrea ariakensis (Mollusca: Ostreidae) and C. hongkongensis expands understandings of stress resistance in sessile oysters
Genomics. 2023 Dec 5:110757. doi: 10.1016/j.ygeno.2023.110757. Online ahead of print.ABSTRACTTo understand the environmental adaptations among sessile bivalves lacking adaptive immunity, a series of analyses were conducted, with special emphasis on the widely distributed C. ariakensis. Employing Pacbio sequencing and Hi-C technologies, whole genome for each of a C. ariakensis (southern China) and C. hongkongensis individual was generated, with the contig N50 reaching 6.2 and 13.0 Mb, respectively. Each genome harbored over 30,000 protein-coding genes, with approximately half of each genome consisting of repeats. Genome ali...
Source: Genomics - December 7, 2023 Category: Genetics & Stem Cells Authors: Xingzhi Zhang Junliang Guan Ming Zou Pingping He Li Zhang Yongxian Chen Wei Li Dapeng Wang Ermeng Yu Fangjie Zhong Peng Zhu Xueyu Yan Youhou Xu Bang Luo Ting Huang Linyuan Jiang Pinyuan Wei Jinxia Peng Source Type: research
Transcriptomic and metabolomic analyses reveal that lemon extract prolongs Drosophila lifespan by affecting metabolism
In this study, we found that 0.05 g/L LE could significantly extend Drosophila lifespan and greatly improve antioxidative and anti-heat stress abilities. Furthermore, transcriptome and metabolome analyses of 10 d flies between the LE-fed and control groups suggested that the differentially expressed gene ppo1 (Prophenoloxidase 1) and metabolite L-DOPA (Levodopa) were co-enriched in the tyrosine metabolism pathway. Overall, our results indicate that affecting metabolism was the main reason for LE extending Drosophila lifespan.PMID:38052259 | DOI:10.1016/j.ygeno.2023.110751 (Source: Genomics)
Source: Genomics - December 5, 2023 Category: Genetics & Stem Cells Authors: Siqi Wang Feng Xiao Ya Yuan Jiamei Li Xiaoxia Liang Xiaolan Fan Mingwang Zhang Taiming Yan Mingyao Yang Zhi He Deying Yang Source Type: research
LncRNA FIRRE regulated endometrial cancer radiotherapy sensitivity via the miR-199b-5p/SIRT1/BECN1 axis-mediated autophagy
CONCLUSION: FIRRE reduced EC cell radiotherapy sensitivity by stimulating autophagy via miR-199b-5p/SIRT1/BECN1 axis.PMID:38052260 | DOI:10.1016/j.ygeno.2023.110750 (Source: Genomics)
Source: Genomics - December 5, 2023 Category: Genetics & Stem Cells Authors: Junhong Cai Ru Wang Yaxiong Chen Chen Zhang Lanyan Fu Cunfu Fan Source Type: research
Transcriptomic and metabolomic analyses reveal that lemon extract prolongs Drosophila lifespan by affecting metabolism
In this study, we found that 0.05 g/L LE could significantly extend Drosophila lifespan and greatly improve antioxidative and anti-heat stress abilities. Furthermore, transcriptome and metabolome analyses of 10 d flies between the LE-fed and control groups suggested that the differentially expressed gene ppo1 (Prophenoloxidase 1) and metabolite L-DOPA (Levodopa) were co-enriched in the tyrosine metabolism pathway. Overall, our results indicate that affecting metabolism was the main reason for LE extending Drosophila lifespan.PMID:38052259 | DOI:10.1016/j.ygeno.2023.110751 (Source: Genomics)
Source: Genomics - December 5, 2023 Category: Genetics & Stem Cells Authors: Siqi Wang Feng Xiao Ya Yuan Jiamei Li Xiaoxia Liang Xiaolan Fan Mingwang Zhang Taiming Yan Mingyao Yang Zhi He Deying Yang Source Type: research
LncRNA FIRRE regulated endometrial cancer radiotherapy sensitivity via the miR-199b-5p/SIRT1/BECN1 axis-mediated autophagy
CONCLUSION: FIRRE reduced EC cell radiotherapy sensitivity by stimulating autophagy via miR-199b-5p/SIRT1/BECN1 axis.PMID:38052260 | DOI:10.1016/j.ygeno.2023.110750 (Source: Genomics)
Source: Genomics - December 5, 2023 Category: Genetics & Stem Cells Authors: Junhong Cai Ru Wang Yaxiong Chen Chen Zhang Lanyan Fu Cunfu Fan Source Type: research
MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks
Genomics. 2023 Nov 25;116(1):110749. doi: 10.1016/j.ygeno.2023.110749. Online ahead of print.ABSTRACTMOTIVATION: N4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological processes. Accurately identifying ac4C sites is of paramount importance for gaining a deeper understanding of their regulatory mechanisms. Nevertheless, the existing experimental techniques for ac4C site identification are characterized by limitations in terms of cost-effectiveness, while the performance of current computational methods in accurately identifying ac4C sites requires further enhancement....
Source: Genomics - November 26, 2023 Category: Genetics & Stem Cells Authors: Zutan Li Bingbing Jin Jingya Fang Source Type: research
MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks
Genomics. 2023 Nov 25;116(1):110749. doi: 10.1016/j.ygeno.2023.110749. Online ahead of print.ABSTRACTMOTIVATION: N4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological processes. Accurately identifying ac4C sites is of paramount importance for gaining a deeper understanding of their regulatory mechanisms. Nevertheless, the existing experimental techniques for ac4C site identification are characterized by limitations in terms of cost-effectiveness, while the performance of current computational methods in accurately identifying ac4C sites requires further enhancement....
Source: Genomics - November 26, 2023 Category: Genetics & Stem Cells Authors: Zutan Li Bingbing Jin Jingya Fang Source Type: research
MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks
Genomics. 2023 Nov 25;116(1):110749. doi: 10.1016/j.ygeno.2023.110749. Online ahead of print.ABSTRACTMOTIVATION: N4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological processes. Accurately identifying ac4C sites is of paramount importance for gaining a deeper understanding of their regulatory mechanisms. Nevertheless, the existing experimental techniques for ac4C site identification are characterized by limitations in terms of cost-effectiveness, while the performance of current computational methods in accurately identifying ac4C sites requires further enhancement....
Source: Genomics - November 26, 2023 Category: Genetics & Stem Cells Authors: Zutan Li Bingbing Jin Jingya Fang Source Type: research
MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks
Genomics. 2023 Nov 25;116(1):110749. doi: 10.1016/j.ygeno.2023.110749. Online ahead of print.ABSTRACTMOTIVATION: N4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological processes. Accurately identifying ac4C sites is of paramount importance for gaining a deeper understanding of their regulatory mechanisms. Nevertheless, the existing experimental techniques for ac4C site identification are characterized by limitations in terms of cost-effectiveness, while the performance of current computational methods in accurately identifying ac4C sites requires further enhancement....
Source: Genomics - November 26, 2023 Category: Genetics & Stem Cells Authors: Zutan Li Bingbing Jin Jingya Fang Source Type: research
