Transcriptomic and metabolomic analyses reveal that lemon extract prolongs Drosophila lifespan by affecting metabolism

In this study, we found that 0.05 g/L LE could significantly extend Drosophila lifespan and greatly improve antioxidative and anti-heat stress abilities. Furthermore, transcriptome and metabolome analyses of 10 d flies between the LE-fed and control groups suggested that the differentially expressed gene ppo1 (Prophenoloxidase 1) and metabolite L-DOPA (Levodopa) were co-enriched in the tyrosine metabolism pathway. Overall, our results indicate that affecting metabolism was the main reason for LE extending Drosophila lifespan.PMID:38052259 | DOI:10.1016/j.ygeno.2023.110751

Source: Genomics - December 5, 2023 Category: Genetics & Stem Cells Authors: Siqi Wang Feng Xiao Ya Yuan Jiamei Li Xiaoxia Liang Xiaolan Fan Mingwang Zhang Taiming Yan Mingyao Yang Zhi He Deying Yang Source Type: research