Transcriptional and functional analysis of plasma exosomal microRNAs in acute viral myocarditis
CONCLUSIONS: Hsa-miR-548a-3p and hsa-miR-500b-5p could serve as a promising biomarker of AVMC. Exosomal miRNAs may have substantial roles in the mechanisms of AVMC.PMID:38163573 | DOI:10.1016/j.ygeno.2023.110775 (Source: Genomics)
Source: Genomics - January 1, 2024 Category: Genetics & Stem Cells Authors: Qinchao Wu Chao Huang Ruolan Chen Daisong Li Guoliang Zhang Haichu Yu Yonghong Li Bingxue Song Ning Zhang Bing Li Xianming Chu Source Type: research
Identification of rat Vstm1 with conservative anti-inflammatory effect between rat and human homologs
Genomics. 2023 Dec 30:110774. doi: 10.1016/j.ygeno.2023.110774. Online ahead of print.ABSTRACTHuman VSTM1 (also known as SIRL1) is an inhibitory immune checkpoint receptor involved in leukocyte activation. Identification of the homologous genes in other species, such as mice and rats, will undoubtedly contribute to functional studies and clinical applications. Here, we successfully cloned the Vstm1 gene in rats, as supported by high-throughput sequencing data. However, Vstm1 is degenerated to a pseudogene in the mouse genome. Rat Vstm1 mRNA contains a complete open reading frame (ORF) of 630 nucleotides encoding 209 amino ...
Source: Genomics - January 1, 2024 Category: Genetics & Stem Cells Authors: Yuzhe Hu Yingzhe Sun Ting Li Wenling Han Pingzhang Wang Source Type: research
Necroptosis-related genes allow novel insights into predicting graft loss and diagnosing delayed graft function in renal transplantation
Genomics. 2023 Dec 30:110778. doi: 10.1016/j.ygeno.2023.110778. Online ahead of print.ABSTRACTIschemia-reperfusion injury (IRI) is an inevitable pathophysiological phenomenon in kidney transplantation. Necroptosis is an undoubtedly important contributing mechanism in renal IRI. We first screened differentially expressed necroptosis-related genes (DENRGs) from public databases. Eight DENRGs were validated by independent datasets and verified by qRT-PCR in a rat IRI model. We used univariate and multivariate Cox regression analyses to establish a prognostic signature, and graft survival analysis was performed. Immune infiltr...
Source: Genomics - January 1, 2024 Category: Genetics & Stem Cells Authors: Jiale Wang Cuinan Lu Jingwen Wang Ying Wang Huanjing Bi Jin Zheng Xiaoming Ding Source Type: research
Genome-wide transcriptomic and biochemical profiling of major depressive disorder: Unravelling association with susceptibility, severity, and antidepressant response
Genomics. 2023 Dec 27:110772. doi: 10.1016/j.ygeno.2023.110772. Online ahead of print.ABSTRACTIdentifying biomarkers for diagnosing Major Depressive Disorder (MDD), assessing its severity, and guiding treatment is crucial. We conducted whole genome transcriptomic study in North Indian population, and analyzed biochemical parameters. Our longitudinal study investigated gene-expression profiles from 72 drug-free MDD patients and 50 healthy controls(HCs) at baseline and 24 patients after 12-weeks of treatment. Gene expression analyses identified differentially expressed genes(DEGs) associated with MDD susceptibility, symptom ...
Source: Genomics - December 29, 2023 Category: Genetics & Stem Cells Authors: Priyanka Singh Ankit Srivastava Lini Philip Simranpreet Kaur Ahuja None Shivangi Chitra Rawat Rintu Kutum Jyoti Yadav Mamta Sood Rakesh Kumar Chadda Debasis Dash Divya Vohora Ritushree Kukreti Source Type: research
Multiple omics analysis reveals the regulation of SIRT5 on mitochondrial function and lipid metabolism during the differentiation of bovine preadipocytes
Genomics. 2023 Dec 27;116(1):110773. doi: 10.1016/j.ygeno.2023.110773. Online ahead of print.ABSTRACTPreadipocyte differentiation represents a critical stage in adipogenesis, with mitochondria playing an undeniable pivotal role. Given the intricate interplay between transcription and metabolic signaling during adipogenesis, the regulation of sirtuin 5 (SIRT5) on mitochondrial function and lipid metabolism was revealed via multiple omics analysis. The findings suggest that SIRT5 plays a crucial role in promoting mitochondrial biosynthesis and maintaining mitochondrial function during preadipocyte differentiation. Moreover, ...
Source: Genomics - December 29, 2023 Category: Genetics & Stem Cells Authors: Jieyun Hong Sayed Haidar Abbas Raza Hongming Ma Weina Cao Yuqing Chong Jiao Wu Dongmei Xi Weidong Deng Source Type: research
A comprehensive phylogenomic study unveils evolutionary patterns and challenges in the mitochondrial genomes of Carcharhiniformes: A focus on Triakidae
Genomics. 2023 Dec 24;116(1):110771. doi: 10.1016/j.ygeno.2023.110771. Online ahead of print.ABSTRACTThe complex evolutionary patterns in the mitochondrial genome (mitogenome) of the most species-rich shark order, the Carcharhiniformes (ground sharks) has led to challenges in the phylogenomic reconstruction of the families and genera belonging to the order, particularly the family Triakidae (houndsharks). The current state of Triakidae phylogeny remains controversial, with arguments for both monophyly and paraphyly within the family. We hypothesize that this variability is triggered by the selection of different a priori p...
Source: Genomics - December 26, 2023 Category: Genetics & Stem Cells Authors: Jessica C Winn Simo N Maduna Aletta E Bester-van der Merwe Source Type: research
A comprehensive phylogenomic study unveils evolutionary patterns and challenges in the mitochondrial genomes of Carcharhiniformes: A focus on Triakidae
Genomics. 2023 Dec 24:110771. doi: 10.1016/j.ygeno.2023.110771. Online ahead of print.ABSTRACTThe complex evolutionary patterns in the mitochondrial genome (mitogenome) of the most species-rich shark order, the Carcharhiniformes (ground sharks) has led to challenges in the phylogenomic reconstruction of the families and genera belonging to the order, particularly the family Triakidae (houndsharks). The current state of Triakidae phylogeny remains controversial, with arguments for both monophyly and paraphyly within the family. We hypothesize that this variability is triggered by the selection of different a priori partitio...
Source: Genomics - December 26, 2023 Category: Genetics & Stem Cells Authors: Jessica C Winn Simo N Maduna Aletta E Bester-van der Merwe Source Type: research
A comprehensive phylogenomic study unveils evolutionary patterns and challenges in the mitochondrial genomes of Carcharhiniformes: A focus on Triakidae
Genomics. 2023 Dec 24:110771. doi: 10.1016/j.ygeno.2023.110771. Online ahead of print.ABSTRACTThe complex evolutionary patterns in the mitochondrial genome (mitogenome) of the most species-rich shark order, the Carcharhiniformes (ground sharks) has led to challenges in the phylogenomic reconstruction of the families and genera belonging to the order, particularly the family Triakidae (houndsharks). The current state of Triakidae phylogeny remains controversial, with arguments for both monophyly and paraphyly within the family. We hypothesize that this variability is triggered by the selection of different a priori partitio...
Source: Genomics - December 26, 2023 Category: Genetics & Stem Cells Authors: Jessica C Winn Simo N Maduna Aletta E Bester-van der Merwe Source Type: research
A comprehensive phylogenomic study unveils evolutionary patterns and challenges in the mitochondrial genomes of Carcharhiniformes: A focus on Triakidae
Genomics. 2023 Dec 24:110771. doi: 10.1016/j.ygeno.2023.110771. Online ahead of print.ABSTRACTThe complex evolutionary patterns in the mitochondrial genome (mitogenome) of the most species-rich shark order, the Carcharhiniformes (ground sharks) has led to challenges in the phylogenomic reconstruction of the families and genera belonging to the order, particularly the family Triakidae (houndsharks). The current state of Triakidae phylogeny remains controversial, with arguments for both monophyly and paraphyly within the family. We hypothesize that this variability is triggered by the selection of different a priori partitio...
Source: Genomics - December 26, 2023 Category: Genetics & Stem Cells Authors: Jessica C Winn Simo N Maduna Aletta E Bester-van der Merwe Source Type: research
A comprehensive phylogenomic study unveils evolutionary patterns and challenges in the mitochondrial genomes of Carcharhiniformes: A focus on Triakidae
Genomics. 2023 Dec 24:110771. doi: 10.1016/j.ygeno.2023.110771. Online ahead of print.ABSTRACTThe complex evolutionary patterns in the mitochondrial genome (mitogenome) of the most species-rich shark order, the Carcharhiniformes (ground sharks) has led to challenges in the phylogenomic reconstruction of the families and genera belonging to the order, particularly the family Triakidae (houndsharks). The current state of Triakidae phylogeny remains controversial, with arguments for both monophyly and paraphyly within the family. We hypothesize that this variability is triggered by the selection of different a priori partitio...
Source: Genomics - December 26, 2023 Category: Genetics & Stem Cells Authors: Jessica C Winn Simo N Maduna Aletta E Bester-van der Merwe Source Type: research
Comprehensive genomic profiling of small bowel adenocarcinoma by tissue and plasma biopsy
Genomics. 2023 Dec 21:110766. doi: 10.1016/j.ygeno.2023.110766. Online ahead of print.ABSTRACTSmall bowel adenocarcinoma (SBA) is a rare and aggressive malignancy with limited treatment options and poor prognosis. The molecular landscape and immunological characteristics of SBA are poorly understood. Here, we performed comprehensive mutation profiling of tissue and plasma biopsies from 143 and 42 patients with SBA. Analysis showed that SBA had a distinct mutation spectrum from left- and right-sided colorectal carcinoma. Plasma biopsy had high concordance with tissue biopsy for single nucleotide variants and structural vari...
Source: Genomics - December 23, 2023 Category: Genetics & Stem Cells Authors: Dan Yu Jianzheng Wang Bo Zheng Mingming Yuan Dejian Gu Rongrong Chen Xiao-Bing Chen Source Type: research
Systems genetics and bioinformatics analyses using ESR1-correlated genes identify potential candidates underlying female bone development
Genomics. 2023 Dec 21:110769. doi: 10.1016/j.ygeno.2023.110769. Online ahead of print.ABSTRACTEstrogen receptor α (ESR1) is involved in E2 signaling and plays a major role in postmenopausal bone loss. However, the molecular network underlying ESR1 has not been explored. We used systems genetics and bioinformatics to identify important genes associated with Esr1 in postmenopausal bone loss. We identified ~2300 Esr1-coexpressed genes in female BXD bone femur, functional analysis of which revealed 'osteoblast signaling' as the most enriched pathway. PPI network led to the identification of 25 'female bone candidates'. The ge...
Source: Genomics - December 23, 2023 Category: Genetics & Stem Cells Authors: Akhilesh K Bajpai Qingqing Gu Yan Jiao Athena Starlard-Davenport Weikuan Gu Leigh Darryl Quarles Zhousheng Xiao Lu Lu Source Type: research
Comprehensive genomic profiling of small bowel adenocarcinoma by tissue and plasma biopsy
Genomics. 2023 Dec 21:110766. doi: 10.1016/j.ygeno.2023.110766. Online ahead of print.ABSTRACTSmall bowel adenocarcinoma (SBA) is a rare and aggressive malignancy with limited treatment options and poor prognosis. The molecular landscape and immunological characteristics of SBA are poorly understood. Here, we performed comprehensive mutation profiling of tissue and plasma biopsies from 143 and 42 patients with SBA. Analysis showed that SBA had a distinct mutation spectrum from left- and right-sided colorectal carcinoma. Plasma biopsy had high concordance with tissue biopsy for single nucleotide variants and structural vari...
Source: Genomics - December 23, 2023 Category: Genetics & Stem Cells Authors: Dan Yu Jianzheng Wang Bo Zheng Mingming Yuan Dejian Gu Rongrong Chen Xiao-Bing Chen Source Type: research
Systems genetics and bioinformatics analyses using ESR1-correlated genes identify potential candidates underlying female bone development
Genomics. 2023 Dec 21:110769. doi: 10.1016/j.ygeno.2023.110769. Online ahead of print.ABSTRACTEstrogen receptor α (ESR1) is involved in E2 signaling and plays a major role in postmenopausal bone loss. However, the molecular network underlying ESR1 has not been explored. We used systems genetics and bioinformatics to identify important genes associated with Esr1 in postmenopausal bone loss. We identified ~2300 Esr1-coexpressed genes in female BXD bone femur, functional analysis of which revealed 'osteoblast signaling' as the most enriched pathway. PPI network led to the identification of 25 'female bone candidates'. The ge...
Source: Genomics - December 23, 2023 Category: Genetics & Stem Cells Authors: Akhilesh K Bajpai Qingqing Gu Yan Jiao Athena Starlard-Davenport Weikuan Gu Leigh Darryl Quarles Zhousheng Xiao Lu Lu Source Type: research
Comprehensive genomic profiling of small bowel adenocarcinoma by tissue and plasma biopsy
Genomics. 2023 Dec 21:110766. doi: 10.1016/j.ygeno.2023.110766. Online ahead of print.ABSTRACTSmall bowel adenocarcinoma (SBA) is a rare and aggressive malignancy with limited treatment options and poor prognosis. The molecular landscape and immunological characteristics of SBA are poorly understood. Here, we performed comprehensive mutation profiling of tissue and plasma biopsies from 143 and 42 patients with SBA. Analysis showed that SBA had a distinct mutation spectrum from left- and right-sided colorectal carcinoma. Plasma biopsy had high concordance with tissue biopsy for single nucleotide variants and structural vari...
Source: Genomics - December 23, 2023 Category: Genetics & Stem Cells Authors: Dan Yu Jianzheng Wang Bo Zheng Mingming Yuan Dejian Gu Rongrong Chen Xiao-Bing Chen Source Type: research
